ID A0A024W0W7_PLAFA Unreviewed; 466 AA.
AC A0A024W0W7;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=tRNA pseudouridine(55) synthase {ECO:0000313|EMBL:ETW34203.1};
GN ORFNames=PFTANZ_05136 {ECO:0000313|EMBL:ETW34203.1};
OS Plasmodium falciparum Tanzania (2000708).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036725 {ECO:0000313|EMBL:ETW34203.1, ECO:0000313|Proteomes:UP000030708};
RN [1] {ECO:0000313|EMBL:ETW34203.1, ECO:0000313|Proteomes:UP000030708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tanzania (2000708) {ECO:0000313|Proteomes:UP000030708};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Tanzania (2000708).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW34203.1, ECO:0000313|Proteomes:UP000030708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tanzania (2000708) {ECO:0000313|Proteomes:UP000030708};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Tanzania (2000708).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the pseudouridine synthase TruB family.
CC {ECO:0000256|ARBA:ARBA00008999}.
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DR EMBL; KI926534; ETW34203.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A024W0W7; -.
DR SMR; A0A024W0W7; -.
DR EnsemblProtists; ETW34203; ETW34203; PFTANZ_05136.
DR eggNOG; KOG2529; Eukaryota.
DR Proteomes; UP000030708; Unassembled WGS sequence.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd02572; PseudoU_synth_hDyskerin; 1.
DR CDD; cd21148; PUA_Cbf5; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR Gene3D; 2.30.130.10; PUA domain; 1.
DR InterPro; IPR012960; Dyskerin-like.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR002501; PsdUridine_synth_N.
DR InterPro; IPR002478; PUA.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR036974; PUA_sf.
DR InterPro; IPR004802; tRNA_PsdUridine_synth_B_fam.
DR InterPro; IPR032819; TruB_C.
DR NCBIfam; TIGR00425; CBF5; 1.
DR PANTHER; PTHR23127; CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5; 1.
DR PANTHER; PTHR23127:SF0; H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1; 1.
DR Pfam; PF08068; DKCLD; 1.
DR Pfam; PF01472; PUA; 1.
DR Pfam; PF16198; TruB_C_2; 1.
DR Pfam; PF01509; TruB_N; 1.
DR SMART; SM01136; DKCLD; 1.
DR SMART; SM00359; PUA; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR PROSITE; PS50890; PUA; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000030708}.
FT DOMAIN 20..78
FT /note="Dyskerin-like"
FT /evidence="ECO:0000259|SMART:SM01136"
FT DOMAIN 269..343
FT /note="PUA"
FT /evidence="ECO:0000259|SMART:SM00359"
FT REGION 436..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 466 AA; 52942 MW; F46945CB9E729445 CRC64;
MEEKKMDYKI EPERKEAAID TSNWPLLLKN YDKLNIRTSH FTPLPMGNSP YSRNIEEYLK
YGIINLDKPS NPSSHEVVSW IRKILRCEKT GHSGTLDPKV TGVLLVCLNR ATRLVKSQQE
SGKEYVCVCK FHSKPKSIEE VKLVLNNFQG AIFQRPPLIC AVKRQLRVRT IYDSKLLDYD
ETNNVCVFWV KCQAGTYIRT LCEHIGLLLG VGAHMQELRR VKSGNMTEYD NMCTLHDILD
AQYIYDTTGD ESYLRKIITP LEKLLINFPR IVIKDSAVNA ICYGAKLTIP GVLRFDNNID
VNTEIVIMTT KGEAVALAIA QMTSTVIATV DHGVVSLTKR VIMDRDTYDV KWGFGNRSME
KKKLILAGLL DKYGKPNEKT PLSWIKSEGY APKLIGTNTT NYNLDIQNHN TVNENNNNNK
IEKNNLTTST INTNINDQIS EGNKNQNENA EKSDSSDLKK KKKRKT
//
