ID A0A024W1X9_PLAFA Unreviewed; 1192 AA.
AC A0A024W1X9;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=ATP-dependent protease La {ECO:0000313|EMBL:ETW34176.1};
GN ORFNames=PFTANZ_05109 {ECO:0000313|EMBL:ETW34176.1};
OS Plasmodium falciparum Tanzania (2000708).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036725 {ECO:0000313|EMBL:ETW34176.1, ECO:0000313|Proteomes:UP000030708};
RN [1] {ECO:0000313|EMBL:ETW34176.1, ECO:0000313|Proteomes:UP000030708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tanzania (2000708) {ECO:0000313|Proteomes:UP000030708};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Tanzania (2000708).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW34176.1, ECO:0000313|Proteomes:UP000030708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tanzania (2000708) {ECO:0000313|Proteomes:UP000030708};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Tanzania (2000708).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01122}.
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DR EMBL; KI926534; ETW34176.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A024W1X9; -.
DR SMR; A0A024W1X9; -.
DR MEROPS; S16.A14; -.
DR EnsemblProtists; ETW34176; ETW34176; PFTANZ_05109.
DR eggNOG; KOG2004; Eukaryota.
DR Proteomes; UP000030708; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.58.1480; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR008269; Lon_proteolytic.
DR InterPro; IPR027065; Lon_Prtase.
DR InterPro; IPR003111; Lon_prtase_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR10046; ATP DEPENDENT LON PROTEASE FAMILY MEMBER; 1.
DR PANTHER; PTHR10046:SF24; LON PROTEASE HOMOLOG 2, PEROXISOMAL; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF05362; Lon_C; 1.
DR Pfam; PF02190; LON_substr_bdg; 1.
DR PRINTS; PR00830; ENDOLAPTASE.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS51786; LON_PROTEOLYTIC; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01122};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01122}; Reference proteome {ECO:0000313|Proteomes:UP000030708};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01122}.
FT DOMAIN 1002..1190
FT /note="Lon proteolytic"
FT /evidence="ECO:0000259|PROSITE:PS51786"
FT REGION 784..823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1096
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
FT ACT_SITE 1139
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
SQ SEQUENCE 1192 AA; 141702 MW; 25AA7083B8E0F116 CRC64;
MLALHWNLLT FRRKANYKRC AYYFYRTSTN KKRNSYENDL KRVKEVKCVV LLNKPLFPGL
TYVLNSDKNV VKYLGVHNDY KEKKNIFVGL FFHKEKTIET HLETNNTFYN KNCNTYKPPD
FLNEKRIKVD KNILKKDIDI CTNINDIYSY GCVGVIKEIL YDEDNLNSIC DEKDYNNINE
SNDIMKKHHF NENNKKEKDN YLLKNHIDMT NMNRSNDLLI HNKLKEKNNE NLNLNMHKSI
YRIVVETMAK IKIEKWNEVE KVGYIDIIRN EDYDINNKEI KIYYLEIIDK IKKIICMNSC
NNREYNILLK YYNTKNLYNL IYFVGNISLS KNNIIQNLLE RNILKDQLKI CIQILCDDIY
LLEMKQKLNE QINEKFENDK KNMIIKEQIN ILKKQQQLLL QTQRQEQNME EYEDGNNTIK
YDHDLLCDEF RNKLMLIRTY ISDEAYRIIN QDINKFMLYN ENSNEYSSTY QYLSTSLNIP
FNKYKMLNDN IFLCEQILNK NHYGLKNVKK YILEYLALYI LNKNIKSKIL LLVGSPGTGK
TSICKSISEC LNIPYYIINM NNIHNMNELI GHRKTYVNSY QGQIINSLIA TKIMNPIVIL
DEFDKVAFIN TNIYNMFLNI FDKEQNEHFK DQYINFEVDI SKIFFICTAN SVENIPDVLL
DRVEIIHIHA YTNMEKIDIY KNYLKHKIEN ETKITSLYLN ISNDVLLYIL DNYTQENGLR
QFYNILYNIY KKRAYMLIKG YNKKVDINLS NISEFVGADQ LIVKKNYHNN VHININKENI
MMGNDKSEKY ERNERNEKNE KNERNEKNEK YEKNDKSEKN EKYEKNKNYE KTCGGSVKSL
AFTENGGQVI IIEVSSLSDK IKSHNYYNYF PLYYNDDYMI STHEEKLKDN KTEKYNELSK
KNNKILEGEN RWELLNNIEM VHPINELFSI SNKSYKNIYN MNYEEDDKKS LTSSFFITED
GYVKEKERAQ QVSFMNNQQV LNSYNEKNKN IYNHDNIVQN NSNKYIKKEN KIYTYNNSPY
ELHPIHNNNN NNNNNNKNNL NHNITITGNV GRIMQESILI AYTYSMKLLN TIMLKFESKP
LHINLSDGDL KKDGPSAGIN FVTCILSYYL NIPVDNTLCM TGEINLNGYV LKIGGLYEKL
NVARNFGIRT LIIPKENSNE YQSLPQHVKQ NIRVLYVHHY SQIFNFIFNN KK
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