ID A0A024W9I1_PLAFA Unreviewed; 3429 AA.
AC A0A024W9I1;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Dynein heavy chain-like protein {ECO:0000313|EMBL:ETW37362.1};
GN ORFNames=PFTANZ_01974 {ECO:0000313|EMBL:ETW37362.1};
OS Plasmodium falciparum Tanzania (2000708).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036725 {ECO:0000313|EMBL:ETW37362.1, ECO:0000313|Proteomes:UP000030708};
RN [1] {ECO:0000313|EMBL:ETW37362.1, ECO:0000313|Proteomes:UP000030708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tanzania (2000708) {ECO:0000313|Proteomes:UP000030708};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Tanzania (2000708).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW37362.1, ECO:0000313|Proteomes:UP000030708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tanzania (2000708) {ECO:0000313|Proteomes:UP000030708};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Tanzania (2000708).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
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DR EMBL; KI926370; ETW37362.1; -; Genomic_DNA.
DR EnsemblProtists; ETW37362; ETW37362; PFTANZ_01974.
DR eggNOG; KOG3595; Eukaryota.
DR Proteomes; UP000030708; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 2.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030708}.
FT DOMAIN 1991..2134
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2782..2936
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 3127..3291
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 2203..2223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2507..2529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1678..1705
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3429 AA; 400606 MW; 52AED4955A597EBD CRC64;
MELEKTHLIN YFLEICPTVL DCSRKELQSV LIKKEEEKIR KFLLDKNINL IVIGKEGNDN
VEREMDDKEN DNVDINMNEE YNSMRTSNLD NKYNNFLFVE LMINYKCVTK SISIAFMKRN
KENFLSLNDK IDNRNKINLS NELLMFVCGQ NDCNTPLDLV YLYLSQGFNN IFDAASGYGQ
NISGPDSSHF NYGTKKDVEN MFSINNKYIG YEGENKVSNI LMNNVSKKLN ELLISMKNAQ
IDLNIPIINL HVDKRIKKLL EENPNVDDMK PDKLKQLCES QEFINQLQKD VTKWIEDIQK
LTRLNGEFKS GGSALSEINF WIGYENALYQ LESQLKNPEV ILTLHILKNA KRYFATMSFD
SDIQLKQSKE YVLNVNILMK DFPIEDLLGA TSIQQIIQAV RNIFNHLKKL KNTTKYPLSR
SYNFVESLSR DLNNTMKKVL CTQSLMNMDY EEFDVLISGC VEIFRLWNEE MRIFKDMVRE
LIKKRSFNER APAKMVFEHI HLQERLDEIK KFRKQHEKFK SVISTVFGSN NKSLGINLYK
DINTAYNIFL SLDPLDLSKN GEDNWEKAKL SYESKVNRVE SQITFKLRDQ LGGSKTSAEM
FHAFSKFNPL FFRPKIRGAI QEYQNTLIQI VVDDLRKLQM IYINGYLKSD SQKVSTIRDI
PLVAGSIIWA KQIERKLEDS LKRIENVLGR GWEQHSEGKI LRQNIDNFKN LLSQNKTFEK
WLKNIKSADK FDMYDNIINI KKLGGNNYEI LANYDFQFFN IFKEVRYLQS INLRVPYSIK
VKADETKLIY PYALTLQKTF RTYMKICISM DNQAKDVPFN QTIKKLVAAI HNTVQNKIKE
GIYLHWDSDI IETYVRKLSE TINTFEFMVD EAMNKNKIVL DSLEKMKTCE VCFDCNELKS
LIEIIQKKAD ELYLEHYRNV HIWIEELNIH INKILTERLE EIIKTWTCEF VNWPNNGKRF
ICKENIHEFK IKNQKFYLHP SIDSMRQIWF SKLSDAINII CGITRIKNIY QKKEKTNEKI
QIKSKGKNTN NEKDDDYIYY TNDSNNKNNI YKNKCDDNNN NIVINDVILD NTYKYIIYFI
DKKIYDNAIK SINDMVDKAQ KYESIWLQYK TLWQIEIGDI ISSFGEDIET WKIFMNEIKQ
TENTFDTLDT EKYFGPIVID YRILQSKVSS KFEIWQKEIV SEFSKKLGEK TLYLKEEIEK
ALYDLNTQSE LKNETEITAM HILSMTPKDI VGIMNTYDMD ILSKTCNSIY NFIEKINEIN
KKEELEWSKK CDLLKQSEVL LEKQRYTFPT NWLYIDNIIG KLETVKQICK YQIKLIKDYL
PYIQSMVLDF DRKVQNNIKE LFEEWNKNKP SHGNANSTKA LQIITTFEER IDIINEQYEI
SEKIRKLLEL ENSESEIGFH VSPNILKEEI NCVKGIWDEL KIIYSNICDM KKMLWSNVDP
KDVKHRLNNL LESIKKIPAK YRQYEIFDNV QNEIQQYLKT YSLLLDLKSE SLKERHWKLI
LQKLNIKIYY NKLTLGNLWS LHLCIHENVL SEILNQAQGE MALEQFLRGL KDTWNEYELE
LVQYQNKCKL IKGWNDIFST IDDHLNAIQS MKISSYIKIF EEETFTWDDK LNRLRNLLDV
WMNVQRKWVY LEGVLKGSSD IKSLLPQEYN RFKIIDSDFI NIMKKTSDKP KLLELFQMEG
FQKQLDRLSD SLSKIQKALG EYLEKQRNKF PRFYFVGDED LLEMIGNSKD AKIIQRNVNK
MFAGINSFIL KENTNDIILG MSSREGEEVL FLEALNISSF NTLKEWLIVL EKSMKSSLEF
YLDEAAKEIL EMDMIECTKI ENNKILLWSE KYPNQIILLC LQILWTTNIE NELINFSKNP
PDESNTLFHK SEKICLNLLE FLAVNVVKQK DHRTRQKFVQ MITELVHQRD VIRILIDKNV
NNVNSFIWLQ YMRYYWDSKK KENKINLIIK MADATFEYGY EYLGMCEKLV QTELTDACFL
TLTQALKMKL GGNPFGPAGT GKTESVKALG AQLGRYVLVF NCDESFDFTA MGRIFVGLCQ
VGAWGCFDEF NRLEERILSA VSEQILTIQT SLVQRKNEIE ILNKKIGLNK NVGIFVTMNP
GYAGRSNLPD NLKQLFRSFA MIEPNKQLIV EVTLFSQGFI SAEHLSSKIV SLFDLCSEQL
SKQPHYDFGL RSLKSVLNSA GNLKRLTLLK DESKYVQNNQ IGFNETLDNN NNNDNNNERK
TTTNTNESNI ISMEQTLLLK SVCDTVYPKL VSSDIILIQS LLKGVFPNVN VGDLEEKGLI
NEIHRLCKLR HFTPEEKWIT KICQIYQIMK LQHGVMLVGD VGTGKSSAWK ILLDSLEALD
NIKGVSYVID AKSLDKEEIY GKLDNINLEW TDGVFTGILR KIIYNSSTQS GNTNKRHWIV
FDGDVDPEWA ENLNSVLDDN KLLTLPNGER LPIPESVRIL FEVDTLKHAT LATVSRCGMI
WFSRDILSPI ILFKHKLNML KYGDNDYPRK MDKFKLLLIN NNERITEKNQ NGNENGNENE
KKNINIINNN NSNNSNNIYS MNHMNNYNVN ANEHNLQQFD NIDSENIMDN IRMNSRIFFE
ENEQETSSSY IIRTIPYRAV NIISDYFEEN EFVHQCLVEA ENYEHVMDYE CIRVIESTCL
LLQKGFDNLV KKNEKINNTL SDDDIEKYIS KWLVVSILWG IGGSLNLETR EKFSMFVQSI
CSIPLPNDLL SKGKMPNMDN TNKISNTLLD YQPNIEDGEW INWKELVQII DVDRTEISDA
TLVIETMDTI RHETILEGWL HLKKPFILCG PPGSGKTMTL TSVLKKSSEF DIASLNFSSG
SLPNLLLQTF DHYCEYVKTT SELVLRPLQP GKWLIIFADE INLPTPDKYD TQRIIMFMRQ
IYESQGFWKY DVNNNSWNWV KIERITFAGA CNPPTDAGRN PLSNRFLRHT SVLYVDFPGY
ESLKQIYGTF NRAILRKFPQ SSHMADNLTQ AMVDFYTKFS ETFTIDMQPH YIYSPRELTR
WKLALYETLE SCDELKTKDL VRLCICEGLR IFQDRLIYKK EKKETDKIID DIFKYSFPDI
TKEDLLRPIL FNSYMKNYYT EIDKKDLKVL ILSKLKIFNE EEINVQLVLF DDVLDHITRI
DRVLRLPLGH LLLVGASGAG KTILSRFVSW INGLSVFQIR AGRNYTTESF EADLRHIMKR
AGIKEEKITF IFDESNVLGP AFLERMNALL ASGEVPGLFE GDNYITLINE CKSAYRSNIG
LDESDIFKKF TKQVQQNLHI VFTMNPANPD FANRQATSPA LFNRCVIDWF GDWPYSALLQ
VASEFIFNLI LPDNNFYMDY VGNEDGPIKG KIQYKNNKAY FLSRAIVEIH NSVVHINNVL
MKKGNRYNYM TPRDFLDFIK HFLKIIDEKK EEVSSQKNHL NSGLNKLKDT EIQVAELRNS
LAIKKKDTC
//
