ID A0A024WXZ0_PLAFA Unreviewed; 484 AA.
AC A0A024WXZ0;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Tr-type G domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFMALIP_00086 {ECO:0000313|EMBL:ETW51883.1};
OS Plasmodium falciparum MaliPS096_E11.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036727 {ECO:0000313|EMBL:ETW51883.1, ECO:0000313|Proteomes:UP000030699};
RN [1] {ECO:0000313|EMBL:ETW51883.1, ECO:0000313|Proteomes:UP000030699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MaliPS096_E11 {ECO:0000313|EMBL:ETW51883.1,
RC ECO:0000313|Proteomes:UP000030699};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum MaliPS096_E11.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW51883.1, ECO:0000313|Proteomes:UP000030699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MaliPS096_E11 {ECO:0000313|EMBL:ETW51883.1,
RC ECO:0000313|Proteomes:UP000030699};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum MaliPS096_E11.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-
CC tRNA to the A-site of ribosomes during protein biosynthesis.
CC {ECO:0000256|ARBA:ARBA00003982}.
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DR EMBL; KI925475; ETW51883.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A024WXZ0; -.
DR EnsemblProtists; ETW51883; ETW51883; PFMALIP_00086.
DR Proteomes; UP000030699; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005665; C:RNA polymerase II, core complex; IEA:UniProt.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd10508; Zn-ribbon_RPB9; 1.
DR Gene3D; 2.20.25.10; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR019761; DNA-dir_RNA_pol-M_15_CS.
DR InterPro; IPR001529; DNA-dir_RNA_pol_M/15kDasu.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR034012; Zn_ribbon_RPB9_C.
DR InterPro; IPR001222; Znf_TFIIS.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR PANTHER; PTHR43721:SF11; SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF02150; RNA_POL_M_15KD; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00661; RPOL9; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 2.
DR PROSITE; PS51722; G_TR_2; 1.
DR PROSITE; PS01030; RNA_POL_M_15KD; 1.
DR PROSITE; PS51133; ZF_TFIIS_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000030699};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00472}.
FT TRANSMEM 456..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 75..116
FT /note="TFIIS-type"
FT /evidence="ECO:0000259|PROSITE:PS51133"
FT DOMAIN 177..447
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 484 AA; 56537 MW; 5A2CABEC4FDA6C87 CRC64;
MAEVRFCEEC NNILYAKSDR KSKKLIYVCR SCEYISLKPN ENNNIVARIN YNYDRKEDIY
IHPETKNDPA LGRVRDWVCK QCGNNEAVFL QLAEKISYNP MALIYVCTNK HCHYWEKEAQ
QINDDNYFNS EKSSDISEDQ DLLNNNFFLK SEKDNFVLSN HDDDFLKVAY DTNLSLMINI
NVGVLGHVDS GKTSLCKCLS QVLSTCALDK HKESKERGIT IDLEKKKKKY DVNQKREIQT
NLLNDQTTDQ KESFLYCKRE EKNDLHNIQY DKTNIEYNEE QNCYDYTNDK HHSNNIYFYD
EEIIQICLVD CPGHHSLLKS IIMGSEITDI IILVIDINKG IQKQTIECLV LCKIINCDII
IVLNKIDLIP LHLREKKINL MKKKIQEAFY KFKSLQSLNY HIVSISANVK GKDNKDVEGD
PPNLLSHDKK GVKILLSGDN KDLPILLSDD KKDPPFFFFF FFVIHFCFVV DPISHYLVHF
KKKR
//
