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Database: UniProt
Entry: A0A037YZ92_CLOTT
LinkDB: A0A037YZ92_CLOTT
Original site: A0A037YZ92_CLOTT 
ID   A0A037YZ92_CLOTT        Unreviewed;       452 AA.
AC   A0A037YZ92;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   25-OCT-2017, entry version 31.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:KAJ49569.1};
GN   ORFNames=CTM_19994 {ECO:0000313|EMBL:KAJ50012.1}, CTM_22429
GN   {ECO:0000313|EMBL:KAJ49569.1};
OS   Clostridium tetanomorphum DSM 665.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1230342 {ECO:0000313|EMBL:KAJ49569.1, ECO:0000313|Proteomes:UP000025063};
RN   [1] {ECO:0000313|Proteomes:UP000025063}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 665 {ECO:0000313|Proteomes:UP000025063};
RA   Bao G., Dong H., Zhang Y., Li Y.;
RT   "Clostridium tetanomorphum DSM 665 genome sequence.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KAJ49569.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 665 {ECO:0000313|EMBL:KAJ49569.1};
RX   PubMed=26572521; DOI=10.1007/s00253-015-7121-0;
RA   Gong F., Bao G., Zhao C., Zhang Y., Li Y., Dong H.;
RT   "Fermentation and genomic analysis of acetone-uncoupled butanol
RT   production by Clostridium tetanomorphum.";
RL   Appl. Microbiol. Biotechnol. 100:1523-1529(2016).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KAJ49569.1}.
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DR   EMBL; APJS01000122; KAJ49569.1; -; Genomic_DNA.
DR   EMBL; APJS01000083; KAJ50012.1; -; Genomic_DNA.
DR   EnsemblBacteria; KAJ49569; KAJ49569; CTM_22429.
DR   EnsemblBacteria; KAJ50012; KAJ50012; CTM_19994.
DR   PATRIC; fig|1230342.3.peg.4009; -.
DR   Proteomes; UP000025063; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000025063};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000025063}.
FT   DOMAIN      147    275       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      359    428       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     155    162       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   452 AA;  51557 MW;  8F77D87C391B740B CRC64;
     MSTQLKDIWE KTLNIVKGEL TEVSFNTWIK SITPMKIEND TLFLCVPNDF TKGILDSRYK
     DLIINALKLI TSKKYNIEFF IASEDIANVE SLNKNHKTIN NASNVVISDE MSTMLNPKYT
     FDSFVIGNSN RFAHAASLAV AEAPAKAYNP LFIYGGVGLG KTHLMHAIGH YVLQNNPNSK
     VVYVSSEKFT NELINSIKDD KNVEFRNKYR NIDILLIDDI QFIAGKERTQ EEFFHTFNAL
     YEANKQIILS SDRPPKEIPT LEDRLRSRFE WGLIADIQAP DFETRMAILK KKADVEHLNI
     PNEVMVYIAT KIKSNIRELE GALIRIVAFS SLTNKEISVD LASEALKDII SNKQSKQITI
     ELIQDIVSSY FNLRVEDFKS ARRTRNVAFP RQIAMYLCRK LTDNSLPKIG EEFGGRDHTT
     VIHAYEKIST SLKEDESLQN TVNELSKKIT QK
//
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