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Database: UniProt
Entry: A0A037ZF09_9RHOB
LinkDB: A0A037ZF09_9RHOB
Original site: A0A037ZF09_9RHOB 
ID   A0A037ZF09_9RHOB        Unreviewed;       495 AA.
AC   A0A037ZF09;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   25-OCT-2017, entry version 23.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378};
GN   ORFNames=ACMU_03690 {ECO:0000313|EMBL:KAJ54198.1};
OS   Actibacterium mucosum KCTC 23349.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Actibacterium.
OX   NCBI_TaxID=1454373 {ECO:0000313|EMBL:KAJ54198.1, ECO:0000313|Proteomes:UP000026249};
RN   [1] {ECO:0000313|EMBL:KAJ54198.1, ECO:0000313|Proteomes:UP000026249}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KCTC 23349 {ECO:0000313|EMBL:KAJ54198.1,
RC   ECO:0000313|Proteomes:UP000026249};
RA   Arahal D.R., Shao Z., Lai Q., Pujalte M.J.;
RT   "Draft Genome Sequence of Actibacterium mucosum KCTC 23349, a Marine
RT   Alphaproteobacterium with Complex Ionic Requirements Isolated from
RT   Mediterranean Seawater at Malvarrosa Beach, Valencia, Spain.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723548}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KAJ54198.1}.
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DR   EMBL; JFKE01000010; KAJ54198.1; -; Genomic_DNA.
DR   RefSeq; WP_035262221.1; NZ_JFKE01000010.1.
DR   EnsemblBacteria; KAJ54198; KAJ54198; ACMU_03690.
DR   Proteomes; UP000026249; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000026249};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723511};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723558};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723518};
KW   Reference proteome {ECO:0000313|Proteomes:UP000026249}.
FT   DOMAIN       17    109       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      133    470       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
SQ   SEQUENCE   495 AA;  53026 MW;  D45572E08539BCAE CRC64;
     MSDLIDDPAP GGNAPEFTVS EISGAVKKTI EGAFGRIRVR GEVGRVFKAR SGHLYYDVKD
     DNNVLACTTW KGQVARLSVV PEEGMEVIVT GKLTAFGAQS KYNMNVDEVT VAGEGALMAM
     LEKRKKALAA EGLFAPERKK PLPYLPEIIG VITSPSGAVI RDILHRLADR FPRKVLIWPV
     AVQGQACAPE VARAIEGFNR LTPGGALPRP DLLIVARGGG SIEDLWGFNE EVVARAVAAS
     DIPLISAVGH ETDTTLIDFV SDKRAPTPTA AAELAVPVRA ELLAWVGDQG ARLTHAATGG
     LGRRGEKLRD LARALPRPES LLENAQVRLD RAGGRLAPAL RGVTSVKRVA LEKQAGALRP
     GALRLRINDA AARLAERATR LSPDTLTRQI DRQREALAQV SARLSRAGTT QVATLRDRLD
     ATDRMRQSLG YHATLERGFA VVRAGEEVVT TKTAAQKAGA LEIEFKDGKL PLDGRPAPRS
     APKKPKPPSQ GSLFD
//
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