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Database: UniProt
Entry: A0A044S8T8_ONCVO
LinkDB: A0A044S8T8_ONCVO
Original site: A0A044S8T8_ONCVO 
ID   A0A044S8T8_ONCVO        Unreviewed;       774 AA.
AC   A0A044S8T8;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   10-MAY-2017, entry version 21.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:OVOC1986};
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Spirurida;
OC   Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282 {ECO:0000313|EnsemblMetazoa:OVOC1986, ECO:0000313|Proteomes:UP000024404};
RN   [1] {ECO:0000313|EnsemblMetazoa:OVOC1986, ECO:0000313|Proteomes:UP000024404}
RP   NUCLEOTIDE SEQUENCE.
RA   Cotton J., Tsai J., Stanley E., Tracey A., Holroyd N., Lustigman S.,
RA   Berriman M.;
RT   "Genome sequencing of Onchocerca volvulus.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:OVOC1986}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2014) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
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DR   EMBL; CBVM010000061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EnsemblMetazoa; OVOC1986; OVOC1986; WBGene00238795.
DR   OrthoDB; EOG091G02ZT; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0007213; P:G-protein coupled acetylcholine receptor signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:EnsemblMetazoa.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR   InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF03520; KCNQ_channel; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01459; KCNQCHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000024404};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024404};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}.
FT   TRANSMEM     39     59       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     71     92       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    113    139       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    178    198       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    239    264       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       43    263       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      484    629       KCNQ_channel. {ECO:0000259|Pfam:PF03520}.
SQ   SEQUENCE   774 AA;  87217 MW;  F56BF3E2A86785FD CRC64;
     MSLMGRPLVY KNYSTDQRFR RVQSKVHNFL ERPRGWKAAG YHFAVLIMVL MCLALSVFST
     MPDFEVHATL ILYYIEIVFV LWLALEYIFR VWSSGCRSRY RGISGRIRFA TSAYCIIDII
     VITASIIVLC IGATGQVFAA SAIRGLRFFQ ILRMLRIDRR AGTWKLLGSV VWAHRQELLT
     TLYIGFLGLI FSSFLVYLCE KSTNEKYSTF ADALWWGVIT LSTVGYGDKT PETWPGKMIA
     SFCALLGISF FALPAGILGS GFALKVQQHQ RQKHLIRRRV PAARLIQCMW RHYAATPESC
     SIATWRVYLA TIQSPNYAVI GHGDDEIGRH RNTTNYNWPE KKSLLCMKWL KKTGNSTRPT
     SSVTDFMRRI SDSAVIMNYP AQTIQQQQSS RGGGSGCQPS FISRIRQSTK RRTGSNVMSH
     SETTLDRASG GDTVELGKVN TFSSGGSIVR TLTVPRQNDD ISEVESLGTL GFSLSGWKAK
     GRSSTSTTYH KKSHDESSAA NRTITTTAIL GATDIDDDSP SLQPKSMEEF TPSLKNVIRA
     IRRIQLLVAR RKFKEALKPY DVKDVIEQYS AGHVDLQARV KHVQQRLDQI VGKPKDEVKV
     SLTHRVIVME MQMQKIDKKL DLLLEMFLEN KNQKKSLNDY AFSFRSPSSA PQRIISNGEP
     GTSSTIKLDN TFPQCITTLS NDAEKLPTSD KSDEDDAQFQ SHCSIYLQTD LSGNSENSLN
     TASARTQFWT PLETPNNINE MPNIIPHQTD NNELQPLLDN QKDEKSTDKP IDFF
//
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