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Database: UniProt
Entry: A0A044T348_ONCVO
LinkDB: A0A044T348_ONCVO
Original site: A0A044T348_ONCVO 
ID   A0A044T348_ONCVO        Unreviewed;       883 AA.
AC   A0A044T348;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   25-APR-2018, entry version 24.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Spirurida;
OC   Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282 {ECO:0000313|EnsemblMetazoa:OVOC3885, ECO:0000313|Proteomes:UP000024404};
RN   [1] {ECO:0000313|EnsemblMetazoa:OVOC3885, ECO:0000313|Proteomes:UP000024404}
RP   NUCLEOTIDE SEQUENCE.
RA   Cotton J., Tsai J., Stanley E., Tracey A., Holroyd N., Lustigman S.,
RA   Berriman M.;
RT   "Genome sequencing of Onchocerca volvulus.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:OVOC3885}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2014) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CMVM020000122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EnsemblMetazoa; OVOC3885; OVOC3885; WBGene00240694.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0044298; C:cell body membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0070382; C:exocytic vesicle; IEA:EnsemblMetazoa.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005771; C:multivesicular body; IEA:EnsemblMetazoa.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IEA:EnsemblMetazoa.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0040002; P:collagen and cuticulin-based cuticle development; IEA:EnsemblMetazoa.
DR   GO; GO:1990182; P:exosomal secretion; IEA:EnsemblMetazoa.
DR   GO; GO:0050891; P:multicellular organismal water homeostasis; IEA:EnsemblMetazoa.
DR   GO; GO:0002119; P:nematode larval development; IEA:EnsemblMetazoa.
DR   GO; GO:0051046; P:regulation of secretion; IEA:EnsemblMetazoa.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000024404};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024404};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    406    430       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    450    469       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    549    572       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    578    602       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    614    638       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    678    697       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    823    847       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       58     78       {ECO:0000256|SAM:Coils}.
FT   COILED       97    117       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   883 AA;  102084 MW;  BE2B0F6AA9EA4057 CRC64;
     MGSLYRSEQM RFCQMIVQKD AAFSCVAELG KHPYVQFKDL NADVNPFQRM YLRDIQRFEE
     LERKLRFLDA QIRKDDIEVN DDVSRDGTYE VLAPHELNQL EGTLVDLERD VIDMNSNNIL
     LKRNYLELKE WEAILEKTDH FFEEGISDVA MHEIEAVEEE SALVLKRPKE PIGFLAGIIN
     RDRVNAFEKV LWRACHKTAF VRTTDIEEEL ENPDSGEMCT KSVFLVFYKG DHLRIIIEKV
     CEGFKAKIYN NCPKNSKDRH AAARDVKARI SDMRTVLGQT QEHRYKVLQA ASSSVKQWQN
     EVRMQKSVYY TLNLFTFDAI GKFFIAECWV PYVDLENVRL ALEEGVRKSG SSVRPVLNLL
     ETTEEPPTYN RVNKFTRVFQ AIVDSYGTAS YLEINPAPYT IITFPFLFSC MFGDLGHGIL
     MLLAGLWMVL REKNLEARNI KDEIFTMFYG GRYIILLMGI FSVHAGFLYN DVFAKSFNLF
     GSKWRNPFPN TEIESWDSES IRLHKEIVID LPPSRSYMHD NGPYWFGVDP IWNLAENRLN
     FSNSLKMKLS VILGIAQMTF GVFLSLLNYI YFKSRIEIFT VFIPQILFML CIFIYLCAQI
     IVKWLFFWVR EEYIFGLLYP GSSCAPSLLI GLISMFMFKD RPLGFVDEME IISVNDGHVT
     YANWPNCYLS QWYPGQSTFE AILVTIAVIC VPIMLFGKPI HFLLHHKKKN VVSDNSVVWK
     NQENEKAEIT LNENGSGLNK RNWEETTSNN EYEEESFADV MVHQAIHTIE YVLGCVSHTA
     SYLRLWALSL AHAQLSEVLW EMVLVQAFGI SGIAGYIAAY FIFFAFGILT VSILVLMEGL
     SAFLHALRLH WVEFQSKFYL GLGYPFMPFY FKDVLLKASV GEK
//
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