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Database: UniProt
Entry: A0A044TKR8_ONCVO
LinkDB: A0A044TKR8_ONCVO
Original site: A0A044TKR8_ONCVO 
ID   A0A044TKR8_ONCVO        Unreviewed;      1908 AA.
AC   A0A044TKR8;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   27-SEP-2017, entry version 24.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Spirurida;
OC   Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282 {ECO:0000313|EnsemblMetazoa:OVOC5021, ECO:0000313|Proteomes:UP000024404};
RN   [1] {ECO:0000313|EnsemblMetazoa:OVOC5021, ECO:0000313|Proteomes:UP000024404}
RP   NUCLEOTIDE SEQUENCE.
RA   Cotton J., Tsai J., Stanley E., Tracey A., Holroyd N., Lustigman S.,
RA   Berriman M.;
RT   "Genome sequencing of Onchocerca volvulus.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:OVOC5021}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2014) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; CBVM010000147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EnsemblMetazoa; OVOC5021; OVOC5021; WBGene00241830.
DR   OMA; PTTKINM; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000024404};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024404};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22   1908       Voltage-dependent L-type calcium channel
FT                                subunit alpha. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001567555.
FT   TRANSMEM    102    118       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    138    159       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    171    187       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    231    254       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    318    339       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    351    373       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    477    495       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    507    528       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    540    560       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    603    625       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    645    664       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    676    698       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    804    822       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    842    861       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    873    890       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    936    955       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1000   1018       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1045   1071       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1116   1137       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1157   1176       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1197   1217       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1263   1283       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1354   1378       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1513   1547       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      707    729       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1908 AA;  218451 MW;  804CF0A8385DB4D8 CRC64;
     MENNLVLTVK ISVLISMMAS STEEDDHHAE DPHKSDLWQQ TLQAAVAATS QSEAAKKRQQ
     QRKPMRQSNV VERSERSLLC LTLSNPLRKA CITIVEWRPF EWLILLMICA NCIALAVYQP
     YPAQDSDTKN IILEQIEYLF IVVFTIECFL KVIALGFLFH PGAYLRNAWN ILDFIIVVIG
     LVSTALSRMN IQGFDVKALR AFRVLRPLRL VSGVPSLQVV LNAILRAMIP LLHIALLVMF
     VIIIYAIIGL ELFCGKLHST CFDLATGQLA QHTPSTCGFA SSAFHCQPNG HNEGVHWICT
     SNTSWQGPNN GITNFDNFGL AMLTVFQCVS LEGWTDVMYW VNDAVGREWP WIYFVTLVIL
     GSFFVLNLVL GVLSGEFSKE REKARARGLF QKFREKQQLE EDLKGYLDWI NQAEDIEPVN
     DDEQEDEQQF NGEELDEEAD EKTDDSRPSW WKKRLRRIQK LNRRCRRGCR RLVKSQTFYW
     LVIVLVLLNT LVLTTEHYKQ ESWLDNFQTV ANLFFVILFS MEMILKMYSL GLTTYTTSQF
     NRFDCFVVIS SIIEFVLVYF DLMKPLGVSV LRSARLLRIF KVTKYWTSLR NLVSSLLNSL
     RSIMSLLLLL FLFIVIFALL GMQVFGGKFN FNPMNPKPRA NFDTFIQALL TVFQIIMYNG
     IASFGGVGSW GVLVSVYYIV LFICGNYILL NVFLAIAVDN LADADSLTNA EKEEEQAEVE
     EEVAEDDYED EKYDENGNEE TRDDSRIVME EEEEGGEIIT ARPRRISELV TVKQQKPIPK
     ASSLFILSHT NPFRVFCNKI VNHSYFTNSV LICILVSSAM LAAEDPLEAQ SPRNTILNYF
     DYFFTTVFTV EITLKVVVYG LMFHKGSFCR NAFNLLDILV VAVSLVSFVL KSDAISVVKI
     LRVLRVLRPL RAINRAKGLK HVVQCVIVAV KTIGNIMLVT FMLQFMFAII GVQLFKGTFF
     RCNDESKTTE YECRGEFLSY EDGDPMKPLR MRREWVKNDF NFDNVGDAMI SLFVVSTFEG
     WPDLLYVAIN SNEEDHGPVY NARQAVAIFF ITFIVVIAFF MMNIFVGFVI VTFQNEGERE
     YENCELDKNQ RKCIEFALKA KPHRRYIPRN RFQYRVWWFV TSQFFEYVIF IIILLNTTTL
     AMKHYPPDPG MDHVLDVLNL IFTGVFALEA VFKIIALNPK NYFGDRQYFL SFPFRKWNAF
     DFVIVLGSFI DIIYGKLSPG SNIISINFFR LFRVMRLVKL LSRGEGIRTL LWTFMKSFQA
     LPYVALLIVL LFFIYAVIGM QVFGKVALND ETHIHRNNNF HTFPAAVLVL FRSATGEAWQ
     QIMLSCSDRD EVKCDPASDD YKQNPDAKCG VDFAYPYFIS FFMLCSFLVI NLFVAVIMDN
     FDYLTRDWSI LGPHHLEEFV RLWSEYDPDA KGRIKHLDVV TLLRKISPPL GFGKLCPHRL
     ACKRLVSMNM PLNSDGTVCF NATLFALVRT NLKIYTEGNI DEVNEQLRSA IRRIWKRTPQ
     KMLDEVVPPA GRDDDVTVGK FYATFLIQDY FRRFKKRKEL ESKGIVPQQT SQAMALQAGL
     RTLHEIGPEL KRAISGNLET DFTLDVEEPQ HRRPHSLFNN IISALGGSAR ANQVYREDRT
     TRSLPMSGVL SKLQICNPNH QLSPAHSLYS NDMMSMATHG HVTTNYSINL PPARSNGGVL
     QRRLPQIPSP NISFDRKLLE NDLIKVSRLP LNAERRYILA NRSMPLDTDE EEEWCGRRDP
     NRVRNDETWT NDGRPGQGLR KPFMLARNQA MAIVGVPTDI SEAFEGTYRP APDGKSVRLP
     LSNRSVLRPS DGNEEGLTER LVGEALALGR YMDERVVEAA RREIAEAYSL EESELESAAA
     TLADARYMEH LGMERCEVRD FNKYSARALL RPAPSQEAPE DDLFVTTL
//
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