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Database: UniProt
Entry: A0A044V6P1_ONCVO
LinkDB: A0A044V6P1_ONCVO
Original site: A0A044V6P1_ONCVO 
ID   A0A044V6P1_ONCVO        Unreviewed;       873 AA.
AC   A0A044V6P1;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   07-JUN-2017, entry version 19.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Spirurida;
OC   Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282 {ECO:0000313|EnsemblMetazoa:OVOC8862, ECO:0000313|Proteomes:UP000024404};
RN   [1] {ECO:0000313|EnsemblMetazoa:OVOC8862, ECO:0000313|Proteomes:UP000024404}
RP   NUCLEOTIDE SEQUENCE.
RA   Cotton J., Tsai J., Stanley E., Tracey A., Holroyd N., Lustigman S.,
RA   Berriman M.;
RT   "Genome sequencing of Onchocerca volvulus.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:OVOC8862}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2014) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CBVM010000250; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EnsemblMetazoa; OVOC8862; OVOC8862; WBGene00245671.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:EnsemblMetazoa.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEA:EnsemblMetazoa.
DR   GO; GO:0040011; P:locomotion; IEA:EnsemblMetazoa.
DR   GO; GO:0002119; P:nematode larval development; IEA:EnsemblMetazoa.
DR   GO; GO:0043068; P:positive regulation of programmed cell death; IEA:EnsemblMetazoa.
DR   GO; GO:0001666; P:response to hypoxia; IEA:EnsemblMetazoa.
DR   GO; GO:0007271; P:synaptic transmission, cholinergic; IEA:EnsemblMetazoa.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000024404};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024404};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    420    444       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    465    483       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    554    573       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    585    609       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    674    693       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    800    825       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   873 AA;  100258 MW;  74AE2CA4E312FB5D CRC64;
     MDSLYRSEEM CLAQLFLQTE AAYACVAELG ELGLVQFRDL NPDVSAFQRK FVNEVRRCDE
     MERKLRFLER EIKKDLIPML DTGENPDAPQ PKEMIDLEAT FEKLENELQE VNQNEEMLKK
     NFSELTELKH ILRKTQQFFD EAGTETIVPP NASVGSGLPE QVVLQETEGI GIELSGAVTG
     QMFANFGFVA GVIHRERLPA FERLLWRACR GNVFLRQSEI AEPLIDPTTG DPVINTVFII
     FFQGDQLKTR VKKICEGFRA TLYPCPDTPQ ERREMSIGVM TRIEDLKTVL GQTQDHRHRV
     LVAASKNVRM WLTKVRKIKS IYHTLNLFNL DVTQKCLIAE CWCPVADLNR IQLALKRGTE
     ESGSTVPSIL NRMSDITEAP PTFHRVNKFT RGFQNIVDAY GIASYREINP APYTMITFPF
     IFAVMFGDCG HGLIMLLCAL FFIYREKQLE SARINDEIFQ TFFNGRYVIF LMGCFSIYTG
     LIYNDVYSKS FNLFGSSWRN IYSDLNKLEY ERELMLTPQW AYYNVSVGPY PIGVDPIWNL
     AESNKLSFLN SMKMKMSVII GIAQMTFGVM LSYENYKYFN SRLDILYMFI PQMLFLGCIF
     IYLCMQIVFK WLLFSAKSGY VLGYEYPSSN CAPSLLIGLI NMFMMKNRAS GFVNSEGIVY
     PQCHLNLWYP GQSFFETLFV LIAAACIPIM LFGKPYMQWK KYKERIAMGT SNLSIHAESN
     GDDAHIIHYD SSRSSVTYIE EKFDFVDVMV YQAIHTIEFA LGCISHTASY LRLWALSLAH
     AQLSDVLWTM VFRQAFMLNG YMGAVATYVL FFLFASLSFS ILVLMEGLSA FLHALRLHWV
     EFQSKFYKGL GHAFVPFSFD TILEEARIAE ENM
//
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