UniProt: A0A045HU66

Database: UniProt
Entry: A0A045HU66_MYCTX

LinkDB:  A0A045HU66_MYCTX 
Original site:  A0A045HU66_MYCTX

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Ontology (5)   
   GO (5)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (10)   
   EMBL (10)   
Protein domain (8)   
   InterPro (6)   
   Pfam (2)   
All databases (26)   

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ID   A0A045HU66_MYCTX        Unreviewed;       286 AA.
AC   A0A045HU66;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:COU98583.1};
DE            EC=1.1.1.157 {ECO:0000313|EMBL:COU98583.1};
GN   Name=fadB2 {ECO:0000313|EMBL:COU98583.1};
GN   ORFNames=A4S10_00495 {ECO:0000313|EMBL:OMH58346.1}, ERS007679_02211
GN   {ECO:0000313|EMBL:COV64264.1}, ERS007703_00217
GN   {ECO:0000313|EMBL:COU98583.1}, ERS007720_01261
GN   {ECO:0000313|EMBL:COV94751.1}, ERS007741_02574
GN   {ECO:0000313|EMBL:COW48192.1}, ERS027646_00854
GN   {ECO:0000313|EMBL:CKR87457.1}, ERS027661_03015
GN   {ECO:0000313|EMBL:CKS39390.1}, ERS053720_00979
GN   {ECO:0000313|EMBL:CFH74148.1}, GJE03_02445
GN   {ECO:0000313|EMBL:QGK77777.1}, SAMEA2683035_00942
GN   {ECO:0000313|EMBL:SGH35151.1};
OS   Mycobacterium tuberculosis.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=1773 {ECO:0000313|EMBL:COU98583.1, ECO:0000313|Proteomes:UP000038802};
RN   [1] {ECO:0000313|EMBL:CFH74148.1, ECO:0000313|Proteomes:UP000046674}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=0351H {ECO:0000313|EMBL:CFH74148.1,
RC   ECO:0000313|Proteomes:UP000046674};
RG   Pathogen Informatics;
RA   Murphy D.;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000038802, ECO:0000313|Proteomes:UP000044938}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2926STDY5723788 {ECO:0000313|EMBL:SGH35151.1,
RC   ECO:0000313|Proteomes:UP000182946}, Bir 172
RC   {ECO:0000313|EMBL:CKR87457.1, ECO:0000313|Proteomes:UP000048948}, Bir
RC   187 {ECO:0000313|EMBL:CKS39390.1, ECO:0000313|Proteomes:UP000049023},
RC   G09801536 {ECO:0000313|EMBL:COV64264.1,
RC   ECO:0000313|Proteomes:UP000045842}, K00500041
RC   {ECO:0000313|Proteomes:UP000038802}, M09401471
RC   {ECO:0000313|EMBL:COV94751.1, ECO:0000313|Proteomes:UP000044938}, and
RC   P00601463 {ECO:0000313|EMBL:COW48192.1,
RC   ECO:0000313|Proteomes:UP000048600};
RG   Pathogen Informatics;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:COU98583.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K00500041 {ECO:0000313|EMBL:COU98583.1};
RA   Murphy D.;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:OMH58346.1, ECO:0000313|Proteomes:UP000189452}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=6548 {ECO:0000313|EMBL:OMH58346.1,
RC   ECO:0000313|Proteomes:UP000189452};
RA   Bigi M., Bigi F., Soria M.A.;
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:OMH58346.1, ECO:0000313|Proteomes:UP000189452}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=6548 {ECO:0000313|EMBL:OMH58346.1,
RC   ECO:0000313|Proteomes:UP000189452};
RA   Bigi M.M., Lopez B., Blanco F.C., Sasiain M.C., De La Barrera S.,
RA   Ritacco V., Bigi F., Soria M.A.;
RT   "Protein polymorphisms may explain contrasting epidemiological fitness of
RT   two variants of a multidrug-resistant Mycobacterium tuberculosis strain.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:QGK77777.1, ECO:0000313|Proteomes:UP000388593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AUSMDU00018547 {ECO:0000313|EMBL:QGK77777.1,
RC   ECO:0000313|Proteomes:UP000388593};
RA   Baines S.L., Goncalves da Silva A., Carter G.P., Jennison A.V.,
RA   Rathnayake I.U., Graham R.M.A., Sintchenko V., Wang Q., Rockett R.J.,
RA   Timms V.J., Martinez E., Ballard S., Tomita T., Isles N., Horan K.A.,
RA   Pitchers W., Stinear T.P., Williamson D.A., Howden B.P., Seemann T.;
RT   "Complete microbial genomes for public health in Australia and Southwest
RT   Pacific.";
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC       {ECO:0000256|ARBA:ARBA00005086}.
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DR   EMBL; CFSW01000005; CFH74148.1; -; Genomic_DNA.
DR   EMBL; CNGE01000101; CKR87457.1; -; Genomic_DNA.
DR   EMBL; CNFU01000722; CKS39390.1; -; Genomic_DNA.
DR   EMBL; CSAE01000012; COU98583.1; -; Genomic_DNA.
DR   EMBL; CSAD01000287; COV64264.1; -; Genomic_DNA.
DR   EMBL; CSAJ01000119; COV94751.1; -; Genomic_DNA.
DR   EMBL; CHKL01000307; COW48192.1; -; Genomic_DNA.
DR   EMBL; LWDQ01000001; OMH58346.1; -; Genomic_DNA.
DR   EMBL; CP045962; QGK77777.1; -; Genomic_DNA.
DR   EMBL; FPTZ01000004; SGH35151.1; -; Genomic_DNA.
DR   RefSeq; WP_003402318.1; NZ_WUCS01000008.1.
DR   STRING; 115862.BBG46_02555; -.
DR   GeneID; 45424430; -.
DR   PATRIC; fig|1773.206.peg.4093; -.
DR   OMA; NGIAHTF; -.
DR   Proteomes; UP000038802; Unassembled WGS sequence.
DR   Proteomes; UP000044938; Unassembled WGS sequence.
DR   Proteomes; UP000045842; Unassembled WGS sequence.
DR   Proteomes; UP000046674; Unassembled WGS sequence.
DR   Proteomes; UP000048600; Unassembled WGS sequence.
DR   Proteomes; UP000048948; Unassembled WGS sequence.
DR   Proteomes; UP000049023; Unassembled WGS sequence.
DR   Proteomes; UP000182946; Unassembled WGS sequence.
DR   Proteomes; UP000189452; Chromosome.
DR   Proteomes; UP000388593; Chromosome.
DR   GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   PIRSF; PIRSF000105; HCDH; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:COU98583.1}.
FT   DOMAIN          8..187
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          190..286
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   SITE            143
FT                   /note="Important for catalytic activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000105-1"
SQ   SEQUENCE   286 AA;  30728 MW;  F1A490B88BCB026B CRC64;
     MSDAIQRVGV VGAGQMGSGI AEVSARAGVE VTVFEPAEAL ITAGRNRIVK SLERAVSAGK
     VTERERDRAL GLLTFTTDLN DLSDRQLVIE AVVEDEAVKS EIFAELDRVV TDPDAVLASN
     TSSIPIMKVA AATKQPQRVL GLHFFNPVPV LPLVELVRTL VTDEAAAART EEFASTVLGK
     QVVRCSDRSG FVVNALLVPY LLSAIRMVEA GFATVEDVDK AVVAGLSHPM GPLRLSDLVG
     LDTLKLIADK MFEEFKEPHY GPPPLLLRMV EAGQLGKKSG RGFYTY
//

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