ID A0A045IAK0_MYCTX Unreviewed; 233 AA.
AC A0A045IAK0;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Helix-turn-helix domain-containing protein {ECO:0000313|EMBL:QGK80121.1};
DE SubName: Full=IclR family transcriptional regulator {ECO:0000313|EMBL:CFH96339.1};
DE SubName: Full=Transcriptional regulator KdgR {ECO:0000313|EMBL:OMH60933.1};
GN Name=kdgR {ECO:0000313|EMBL:CFH96339.1};
GN ORFNames=A4S10_03118 {ECO:0000313|EMBL:OMH60933.1}, ERS007679_02554
GN {ECO:0000313|EMBL:COV83841.1}, ERS027646_00241
GN {ECO:0000313|EMBL:CKR62624.1}, ERS027659_01983
GN {ECO:0000313|EMBL:CKR67675.1}, ERS053720_03688
GN {ECO:0000313|EMBL:CFH96339.1}, GJE03_15675
GN {ECO:0000313|EMBL:QGK80121.1}, SAMEA2683035_03547
GN {ECO:0000313|EMBL:SGI42036.1};
OS Mycobacterium tuberculosis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773 {ECO:0000313|EMBL:CFH96339.1, ECO:0000313|Proteomes:UP000046674};
RN [1] {ECO:0000313|EMBL:CFH96339.1, ECO:0000313|Proteomes:UP000046674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0351H {ECO:0000313|EMBL:CFH96339.1,
RC ECO:0000313|Proteomes:UP000046674};
RG Pathogen Informatics;
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000045842, ECO:0000313|Proteomes:UP000048948}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2926STDY5723788 {ECO:0000313|EMBL:SGI42036.1,
RC ECO:0000313|Proteomes:UP000182946}, Bir 172
RC {ECO:0000313|EMBL:CKR62624.1, ECO:0000313|Proteomes:UP000048948}, Bir
RC 185 {ECO:0000313|EMBL:CKR67675.1, ECO:0000313|Proteomes:UP000050164},
RC and G09801536 {ECO:0000313|EMBL:COV83841.1,
RC ECO:0000313|Proteomes:UP000045842};
RG Pathogen Informatics;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:OMH60933.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH60933.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M., Bigi F., Soria M.A.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:OMH60933.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH60933.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M.M., Lopez B., Blanco F.C., Sasiain M.C., De La Barrera S.,
RA Ritacco V., Bigi F., Soria M.A.;
RT "Protein polymorphisms may explain contrasting epidemiological fitness of
RT two variants of a multidrug-resistant Mycobacterium tuberculosis strain.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:QGK80121.1, ECO:0000313|Proteomes:UP000388593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AUSMDU00018547 {ECO:0000313|EMBL:QGK80121.1,
RC ECO:0000313|Proteomes:UP000388593};
RA Baines S.L., Goncalves da Silva A., Carter G.P., Jennison A.V.,
RA Rathnayake I.U., Graham R.M.A., Sintchenko V., Wang Q., Rockett R.J.,
RA Timms V.J., Martinez E., Ballard S., Tomita T., Isles N., Horan K.A.,
RA Pitchers W., Stinear T.P., Williamson D.A., Howden B.P., Seemann T.;
RT "Complete microbial genomes for public health in Australia and Southwest
RT Pacific.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CFSW01000031; CFH96339.1; -; Genomic_DNA.
DR EMBL; CNGE01000021; CKR62624.1; -; Genomic_DNA.
DR EMBL; CNFT01000420; CKR67675.1; -; Genomic_DNA.
DR EMBL; CSAD01000362; COV83841.1; -; Genomic_DNA.
DR EMBL; LWDQ01000001; OMH60933.1; -; Genomic_DNA.
DR EMBL; CP045962; QGK80121.1; -; Genomic_DNA.
DR EMBL; FPTZ01000034; SGI42036.1; -; Genomic_DNA.
DR RefSeq; WP_003415115.1; NZ_WUCS01000004.1.
DR GeneID; 45426978; -.
DR PATRIC; fig|1773.206.peg.1420; -.
DR OMA; EPDRLHR; -.
DR Proteomes; UP000045842; Unassembled WGS sequence.
DR Proteomes; UP000046674; Unassembled WGS sequence.
DR Proteomes; UP000048948; Unassembled WGS sequence.
DR Proteomes; UP000050164; Unassembled WGS sequence.
DR Proteomes; UP000182946; Unassembled WGS sequence.
DR Proteomes; UP000189452; Chromosome.
DR Proteomes; UP000388593; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR30136; HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, ICLR FAMILY; 1.
DR PANTHER; PTHR30136:SF39; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF09339; HTH_IclR; 1.
DR Pfam; PF01614; IclR; 1.
DR SMART; SM00346; HTH_ICLR; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51077; HTH_ICLR; 1.
DR PROSITE; PS51078; ICLR_ED; 1.
PE 4: Predicted;
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 7..66
FT /note="HTH iclR-type"
FT /evidence="ECO:0000259|PROSITE:PS51077"
FT DOMAIN 67..233
FT /note="IclR-ED"
FT /evidence="ECO:0000259|PROSITE:PS51078"
SQ SEQUENCE 233 AA; 24316 MW; 304CB58FA13AB252 CRC64;
MRQHSGIGVL DKAVGVLHAV AESPCGLAEL CDRTDLPRAT AYRLAAALEV HRLLGRGQDG
HWRLGPAITE LATHVDDPLL VACAAVLPQL RDATGESVQV YRREGTSRVC VAALEPAAGL
RDTVPVGARL PMTAGSGAKV LLAHTDAATQ AAVLPKAVFS ARALAEVCRR GWAQSVAERE
PGVASVSAPV RDGRGVVIAA ISVSGPIDRM GRRPGVRWAA DLLSAADALT RRL
//
