ID A0A045IKT7_MYCTX Unreviewed; 711 AA.
AC A0A045IKT7;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=(R)-benzylsuccinyl-CoA dehydrogenase {ECO:0000313|EMBL:OMH61551.1};
DE SubName: Full=Acyl-CoA dehydrogenase {ECO:0000313|EMBL:QGK80664.1, ECO:0000313|EMBL:SGH24913.1};
DE EC=1.3.8.3 {ECO:0000313|EMBL:OMH61551.1, ECO:0000313|EMBL:SGH24913.1};
GN Name=bbsG_3 {ECO:0000313|EMBL:SGH24913.1};
GN ORFNames=A4S10_03743 {ECO:0000313|EMBL:OMH61551.1}, ERS053720_02820
GN {ECO:0000313|EMBL:CFH88271.1}, GJE03_18780
GN {ECO:0000313|EMBL:QGK80664.1}, SAMEA2683035_00672
GN {ECO:0000313|EMBL:SGH24913.1};
OS Mycobacterium tuberculosis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773 {ECO:0000313|EMBL:SGH24913.1, ECO:0000313|Proteomes:UP000182946};
RN [1] {ECO:0000313|EMBL:CFH88271.1, ECO:0000313|Proteomes:UP000046674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0351H {ECO:0000313|EMBL:CFH88271.1,
RC ECO:0000313|Proteomes:UP000046674};
RG Pathogen Informatics;
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OMH61551.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH61551.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M., Bigi F., Soria M.A.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:SGH24913.1, ECO:0000313|Proteomes:UP000182946}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2926STDY5723788 {ECO:0000313|EMBL:SGH24913.1,
RC ECO:0000313|Proteomes:UP000182946};
RG Pathogen Informatics;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:OMH61551.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH61551.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M.M., Lopez B., Blanco F.C., Sasiain M.C., De La Barrera S.,
RA Ritacco V., Bigi F., Soria M.A.;
RT "Protein polymorphisms may explain contrasting epidemiological fitness of
RT two variants of a multidrug-resistant Mycobacterium tuberculosis strain.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:QGK80664.1, ECO:0000313|Proteomes:UP000388593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AUSMDU00018547 {ECO:0000313|EMBL:QGK80664.1,
RC ECO:0000313|Proteomes:UP000388593};
RA Baines S.L., Goncalves da Silva A., Carter G.P., Jennison A.V.,
RA Rathnayake I.U., Graham R.M.A., Sintchenko V., Wang Q., Rockett R.J.,
RA Timms V.J., Martinez E., Ballard S., Tomita T., Isles N., Horan K.A.,
RA Pitchers W., Stinear T.P., Williamson D.A., Howden B.P., Seemann T.;
RT "Complete microbial genomes for public health in Australia and Southwest
RT Pacific.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the acyl-CoA dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009347}.
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DR EMBL; CFSW01000018; CFH88271.1; -; Genomic_DNA.
DR EMBL; LWDQ01000001; OMH61551.1; -; Genomic_DNA.
DR EMBL; CP045962; QGK80664.1; -; Genomic_DNA.
DR EMBL; FPTZ01000003; SGH24913.1; -; Genomic_DNA.
DR RefSeq; WP_003419394.1; NZ_WUCS01000002.1.
DR AlphaFoldDB; A0A045IKT7; -.
DR GeneID; 45427561; -.
DR PATRIC; fig|1773.206.peg.3970; -.
DR OMA; DWAICLA; -.
DR Proteomes; UP000046674; Unassembled WGS sequence.
DR Proteomes; UP000182946; Unassembled WGS sequence.
DR Proteomes; UP000189452; Chromosome.
DR Proteomes; UP000388593; Chromosome.
DR GO; GO:0033734; F:(R)-benzylsuccinyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR Gene3D; 1.10.540.10; Acyl-CoA dehydrogenase/oxidase, N-terminal domain; 2.
DR Gene3D; 2.40.110.10; Butyryl-CoA Dehydrogenase, subunit A, domain 2; 1.
DR Gene3D; 1.20.140.10; Butyryl-CoA Dehydrogenase, subunit A, domain 3; 2.
DR InterPro; IPR006091; Acyl-CoA_Oxase/DH_mid-dom.
DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR InterPro; IPR036250; AcylCo_DH-like_C.
DR InterPro; IPR009075; AcylCo_DH/oxidase_C.
DR InterPro; IPR013786; AcylCoA_DH/ox_N.
DR InterPro; IPR037069; AcylCoA_DH/ox_N_sf.
DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom_sf.
DR PANTHER; PTHR43292; ACYL-COA DEHYDROGENASE; 1.
DR PANTHER; PTHR43292:SF4; ACYL-COA DEHYDROGENASE FADE34; 1.
DR Pfam; PF00441; Acyl-CoA_dh_1; 2.
DR Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR Pfam; PF02771; Acyl-CoA_dh_N; 2.
DR SUPFAM; SSF47203; Acyl-CoA dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF56645; Acyl-CoA dehydrogenase NM domain-like; 2.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000313|EMBL:SGH24913.1}.
FT DOMAIN 6..102
FT /note="Acyl-CoA dehydrogenase/oxidase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02771"
FT DOMAIN 212..328
FT /note="Acyl-CoA dehydrogenase/oxidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00441"
FT DOMAIN 370..458
FT /note="Acyl-CoA dehydrogenase/oxidase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02771"
FT DOMAIN 462..556
FT /note="Acyl-CoA oxidase/dehydrogenase middle"
FT /evidence="ECO:0000259|Pfam:PF02770"
FT DOMAIN 568..707
FT /note="Acyl-CoA dehydrogenase/oxidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00441"
SQ SEQUENCE 711 AA; 74578 MW; 52B632900EFE196D CRC64;
MVATVTDEQS AARELVRGWA RTAASGAAAT AAVRDMEYGF EEGNADAWRP VFAGLAGLGL
FGVAVPEDCG GAGGSIEDLC AMVDEAARAL VPGPVATTAV ATLVVSDPKL RSALASGERF
AGVAIDGGVQ VDPKTSTASG TVGRVLGGAP GGVVLLPADG NWLLVDTACD EVVVEPLRAT
DFSLPLARMV LTSAPVTVLE VSGERVEDLA ATVLAAEAAG VARWTLDTAV AYAKVREQFG
KPIGSFQAVK HLCAQMLCRA EQADVAAADA ARAAADSDGT QLSIAAAVAA SIGIDAAKAN
AKDCIQVLGG IGCTWEHDAH LYLRRAHGIG GFLGGSGRWL RRVTALTQAG VRRRLGVDLA
EVAGLRPEIA AAVAEVAALP EEKRQVALAD TGLLAPHWPA PYGRGASPAE QLLIDQELAA
AKVERPDLVI GWWAAPTILE HGTPEQIERF VPATMRGEFL WCQLFSEPGA GSDLASLRTK
AVRADGGWLL TGQKVWTSAA HKARWGVCLA RTDPDAPKHK GITYFLVDMT TPGIEIRPLR
EITGDSLFNE VFLDNVFVPD EMVVGAVNDG WRLARTTLAN ERVAMATGTA LGNPMEELLK
VLGDMELDVA QQDRLGRLIL LAQAGALLDR RIAELAVGGQ DPGAQSSVRK LIGVRYRQAL
AEYLMEVSDG GGLVENRAVY DFLNTRCLTI AGGTEQILLT VAAERLLGLP R
//
