ID A0A045IUK1_MYCTX Unreviewed; 502 AA.
AC A0A045IUK1;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Fatty-acid-CoA synthetase FadD17 (Fatty-acid-CoA synthase) (Fatty-acid-CoA ligase) {ECO:0000313|EMBL:CNV43314.1};
DE EC=6.2.1.- {ECO:0000313|EMBL:CNV43314.1};
DE EC=6.2.1.3 {ECO:0000313|EMBL:CNV43314.1};
DE SubName: Full=Long-chain-fatty-acid--CoA ligase FadD17 {ECO:0000313|EMBL:QGK80598.1};
GN Name=fadD_2 {ECO:0000313|EMBL:CNV43314.1};
GN Synonyms=fadD_3 {ECO:0000313|EMBL:CFH95987.1};
GN ORFNames=ERS007665_02953 {ECO:0000313|EMBL:CNV43314.1},
GN ERS027646_02919 {ECO:0000313|EMBL:CKT06692.1}, ERS053720_03643
GN {ECO:0000313|EMBL:CFH95987.1}, GJE03_18435
GN {ECO:0000313|EMBL:QGK80598.1};
OS Mycobacterium tuberculosis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773 {ECO:0000313|EMBL:CNV43314.1, ECO:0000313|Proteomes:UP000045274};
RN [1] {ECO:0000313|EMBL:CFH95987.1, ECO:0000313|Proteomes:UP000046674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0351H {ECO:0000313|EMBL:CFH95987.1,
RC ECO:0000313|Proteomes:UP000046674};
RG Pathogen Informatics;
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000045274, ECO:0000313|Proteomes:UP000048948}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bir 172 {ECO:0000313|EMBL:CKT06692.1,
RC ECO:0000313|Proteomes:UP000048948}, and D00700688
RC {ECO:0000313|EMBL:CNV43314.1, ECO:0000313|Proteomes:UP000045274};
RG Pathogen Informatics;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QGK80598.1, ECO:0000313|Proteomes:UP000388593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AUSMDU00018547 {ECO:0000313|EMBL:QGK80598.1,
RC ECO:0000313|Proteomes:UP000388593};
RA Baines S.L., Goncalves da Silva A., Carter G.P., Jennison A.V.,
RA Rathnayake I.U., Graham R.M.A., Sintchenko V., Wang Q., Rockett R.J.,
RA Timms V.J., Martinez E., Ballard S., Tomita T., Isles N., Horan K.A.,
RA Pitchers W., Stinear T.P., Williamson D.A., Howden B.P., Seemann T.;
RT "Complete microbial genomes for public health in Australia and Southwest
RT Pacific.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CFSW01000030; CFH95987.1; -; Genomic_DNA.
DR EMBL; CNGE01000606; CKT06692.1; -; Genomic_DNA.
DR EMBL; CQPW01000716; CNV43314.1; -; Genomic_DNA.
DR EMBL; CP045962; QGK80598.1; -; Genomic_DNA.
DR RefSeq; WP_003901655.1; NZ_WUCS01000025.1.
DR OMA; NAIMAGW; -.
DR Proteomes; UP000045274; Unassembled WGS sequence.
DR Proteomes; UP000046674; Unassembled WGS sequence.
DR Proteomes; UP000048948; Unassembled WGS sequence.
DR Proteomes; UP000388593; Chromosome.
DR GO; GO:0004467; F:long-chain fatty acid-CoA ligase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43107:SF15; FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A; 1.
DR PANTHER; PTHR43107; LONG-CHAIN FATTY ACID TRANSPORT PROTEIN; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:CNV43314.1}.
FT DOMAIN 24..353
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 404..480
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 502 AA; 53739 MW; 0AF9A7B3B9C83A4D CRC64;
MTPTHPTVTE LLLPLSEIDD RGVYFEDSFT SWRDHIRHGA AIAAALRERL DPARPPHVGV
LLQNTPFFSA TLVAGALSGI VPVGLNPVRR GAALAGDIAK ADCQLVLTGS GSAEVPADVE
HINVDSPEWT DEVAAHRDTE VRFRSADLAD LFMLIFTSGT SGDPKAVKCS HRKVAIAGVT
ITQRFSLGRD DVCYVSMPLF HSNAVLVGWA VAAACQGSMA LRRKFSASQF LADVRRYGAT
YANYVGKPLS YVLATPELPD DADNPLRAVY GNEGVPGDID RFGRRFGCVV MDGFGSTEGG
VAITRTLDTP AGALGPLPGG IQIVDPDTGE PCPTGVVGEL VNTAGPGGFE GYYNDEAAEA
ERMAGGVYHS GDLAYRDDAG YAYFAGRLGD WMRVDGENLG TAPIERVLMR YPDATEVAVY
PVPDPVVGDQ VMAALVLAPG TKFDADKFRA FLTEQPDLGH KQWPSYVRVS AGLPRTMTFK
VIKRQLSAEG VACADPVWPI RR
//
