ID A0A045J2D2_MYCTX Unreviewed; 210 AA.
AC A0A045J2D2;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=HTH-type transcriptional regulator AcrR {ECO:0000313|EMBL:OMH58176.1};
DE SubName: Full=TetR family transcriptional regulator {ECO:0000313|EMBL:CKS02802.1};
GN Name=acrR {ECO:0000313|EMBL:CKS02802.1};
GN Synonyms=acrR_1 {ECO:0000313|EMBL:OMH58176.1};
GN ORFNames=A4S10_00324 {ECO:0000313|EMBL:OMH58176.1}, ERS007657_03305
GN {ECO:0000313|EMBL:CFR96973.1}, ERS007679_02277
GN {ECO:0000313|EMBL:COV68206.1}, ERS007681_02293
GN {ECO:0000313|EMBL:CFE39904.1}, ERS007688_01622
GN {ECO:0000313|EMBL:CFE50013.1}, ERS007703_02625
GN {ECO:0000313|EMBL:COW05089.1}, ERS027646_00827
GN {ECO:0000313|EMBL:CKR86175.1}, ERS027659_02538
GN {ECO:0000313|EMBL:CKS02802.1}, ERS027661_02360
GN {ECO:0000313|EMBL:CKR94094.1}, ERS053720_03380
GN {ECO:0000313|EMBL:CFH93698.1}, GJE03_01610
GN {ECO:0000313|EMBL:QGK77629.1}, SAMEA2683035_01767
GN {ECO:0000313|EMBL:SGH68715.1};
OS Mycobacterium tuberculosis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773 {ECO:0000313|EMBL:CKS02802.1, ECO:0000313|Proteomes:UP000050164};
RN [1] {ECO:0000313|EMBL:COW05089.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K00500041 {ECO:0000313|EMBL:COW05089.1};
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CFH93698.1, ECO:0000313|Proteomes:UP000046674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0351H {ECO:0000313|EMBL:CFH93698.1,
RC ECO:0000313|Proteomes:UP000046674};
RG Pathogen Informatics;
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000038802, ECO:0000313|Proteomes:UP000045842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2926STDY5723788 {ECO:0000313|EMBL:SGH68715.1,
RC ECO:0000313|Proteomes:UP000182946}, Bir 172
RC {ECO:0000313|EMBL:CKR86175.1, ECO:0000313|Proteomes:UP000048948}, Bir
RC 185 {ECO:0000313|EMBL:CKS02802.1, ECO:0000313|Proteomes:UP000050164},
RC Bir 187 {ECO:0000313|EMBL:CKR94094.1,
RC ECO:0000313|Proteomes:UP000049023}, C09601061
RC {ECO:0000313|EMBL:CFR96973.1, ECO:0000313|Proteomes:UP000046680},
RC G09801536 {ECO:0000313|EMBL:COV68206.1,
RC ECO:0000313|Proteomes:UP000045842}, G09901357
RC {ECO:0000313|EMBL:CFE39904.1, ECO:0000313|Proteomes:UP000048289},
RC H09601792 {ECO:0000313|EMBL:CFE50013.1,
RC ECO:0000313|Proteomes:UP000046947}, and K00500041
RC {ECO:0000313|Proteomes:UP000038802};
RG Pathogen Informatics;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:OMH58176.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH58176.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M., Bigi F., Soria M.A.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:OMH58176.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH58176.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M.M., Lopez B., Blanco F.C., Sasiain M.C., De La Barrera S.,
RA Ritacco V., Bigi F., Soria M.A.;
RT "Protein polymorphisms may explain contrasting epidemiological fitness of
RT two variants of a multidrug-resistant Mycobacterium tuberculosis strain.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:QGK77629.1, ECO:0000313|Proteomes:UP000388593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AUSMDU00018547 {ECO:0000313|EMBL:QGK77629.1,
RC ECO:0000313|Proteomes:UP000388593};
RA Baines S.L., Goncalves da Silva A., Carter G.P., Jennison A.V.,
RA Rathnayake I.U., Graham R.M.A., Sintchenko V., Wang Q., Rockett R.J.,
RA Timms V.J., Martinez E., Ballard S., Tomita T., Isles N., Horan K.A.,
RA Pitchers W., Stinear T.P., Williamson D.A., Howden B.P., Seemann T.;
RT "Complete microbial genomes for public health in Australia and Southwest
RT Pacific.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CFOE01000289; CFE39904.1; -; Genomic_DNA.
DR EMBL; CFOH01000218; CFE50013.1; -; Genomic_DNA.
DR EMBL; CFSW01000025; CFH93698.1; -; Genomic_DNA.
DR EMBL; CGCX01001541; CFR96973.1; -; Genomic_DNA.
DR EMBL; CNGE01000097; CKR86175.1; -; Genomic_DNA.
DR EMBL; CNFU01000491; CKR94094.1; -; Genomic_DNA.
DR EMBL; CNFT01000616; CKS02802.1; -; Genomic_DNA.
DR EMBL; CSAD01000300; COV68206.1; -; Genomic_DNA.
DR EMBL; CSAE01000296; COW05089.1; -; Genomic_DNA.
DR EMBL; LWDQ01000001; OMH58176.1; -; Genomic_DNA.
DR EMBL; CP045962; QGK77629.1; -; Genomic_DNA.
DR EMBL; FPTZ01000010; SGH68715.1; -; Genomic_DNA.
DR RefSeq; WP_003401571.1; NZ_WUCS01000024.1.
DR STRING; 115862.BBG46_01705; -.
DR PATRIC; fig|1773.206.peg.2371; -.
DR OMA; AMFIQVR; -.
DR Proteomes; UP000038802; Unassembled WGS sequence.
DR Proteomes; UP000045842; Unassembled WGS sequence.
DR Proteomes; UP000046674; Unassembled WGS sequence.
DR Proteomes; UP000046680; Unassembled WGS sequence.
DR Proteomes; UP000046947; Unassembled WGS sequence.
DR Proteomes; UP000048289; Unassembled WGS sequence.
DR Proteomes; UP000048948; Unassembled WGS sequence.
DR Proteomes; UP000049023; Unassembled WGS sequence.
DR Proteomes; UP000050164; Unassembled WGS sequence.
DR Proteomes; UP000182946; Unassembled WGS sequence.
DR Proteomes; UP000189452; Chromosome.
DR Proteomes; UP000388593; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProt.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR InterPro; IPR039538; BetI_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR PANTHER; PTHR30055:SF226; HTH-TYPE TRANSCRIPTIONAL REPRESSOR RV1474C; 1.
DR Pfam; PF13977; TetR_C_6; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 13..73
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 36..55
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 210 AA; 23397 MW; 49A3353B9E1D401D CRC64;
MGVPAKKKQQ QGERSRESIL DATERLMATK GYAATSISDI RDACGLAPSS IYWHFGSKEG
VLAAMMERGA QRFFAAIPTW DEAHGPVEQR SERQLTELVS LQSQHPDFLR LFYLLSMERS
QDPAVAAVVR RVRNTAIARF RDSITHLLPS DIPPGKADLV VAELTAFAVA LSDGVYFAGH
LEPDTTDVER MYRRLRQALE ALIPVLLEET
//
