ID A0A045J2P3_MYCTX Unreviewed; 500 AA.
AC A0A045J2P3;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Leupeptin-inactivating enzyme 1 {ECO:0000313|EMBL:OMH58295.1};
DE EC=3.4.24.- {ECO:0000313|EMBL:CFH74529.1, ECO:0000313|EMBL:OMH58295.1};
DE SubName: Full=Lipoprotein aminopeptidase LpqL {ECO:0000313|EMBL:CFH74529.1};
DE EC=3.4.11.- {ECO:0000313|EMBL:CFH74529.1};
DE SubName: Full=M20/M25/M40 family metallo-hydrolase {ECO:0000313|EMBL:QGK77736.1};
GN Name=lpqL {ECO:0000313|EMBL:CFH74529.1};
GN Synonyms=lieA {ECO:0000313|EMBL:OMH58295.1};
GN ORFNames=A4S10_00444 {ECO:0000313|EMBL:OMH58295.1}, ERS007657_00127
GN {ECO:0000313|EMBL:CFR64996.1}, ERS007665_00449
GN {ECO:0000313|EMBL:CNU12297.1}, ERS007679_03406
GN {ECO:0000313|EMBL:COW22173.1}, ERS007681_02496
GN {ECO:0000313|EMBL:CFE40400.1}, ERS007688_01548
GN {ECO:0000313|EMBL:CFE49701.1}, ERS007703_01213
GN {ECO:0000313|EMBL:COV35621.1}, ERS007741_00831
GN {ECO:0000313|EMBL:COV86524.1}, ERS027646_00396
GN {ECO:0000313|EMBL:CKR67715.1}, ERS027659_00909
GN {ECO:0000313|EMBL:CKR20190.1}, ERS027661_03246
GN {ECO:0000313|EMBL:CKS56318.1}, ERS053720_01030
GN {ECO:0000313|EMBL:CFH74529.1}, GJE03_02185
GN {ECO:0000313|EMBL:QGK77736.1}, SAMEA2683035_00891
GN {ECO:0000313|EMBL:SGH33605.1};
OS Mycobacterium tuberculosis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773 {ECO:0000313|EMBL:CFH74529.1, ECO:0000313|Proteomes:UP000046674};
RN [1] {ECO:0000313|EMBL:COV35621.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K00500041 {ECO:0000313|EMBL:COV35621.1};
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000038802, ECO:0000313|Proteomes:UP000045274}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2926STDY5723788 {ECO:0000313|EMBL:SGH33605.1,
RC ECO:0000313|Proteomes:UP000182946}, Bir 172
RC {ECO:0000313|EMBL:CKR67715.1, ECO:0000313|Proteomes:UP000048948}, Bir
RC 185 {ECO:0000313|EMBL:CKR20190.1, ECO:0000313|Proteomes:UP000050164},
RC Bir 187 {ECO:0000313|EMBL:CKS56318.1,
RC ECO:0000313|Proteomes:UP000049023}, C09601061
RC {ECO:0000313|EMBL:CFR64996.1, ECO:0000313|Proteomes:UP000046680},
RC D00700688 {ECO:0000313|EMBL:CNU12297.1,
RC ECO:0000313|Proteomes:UP000045274}, G09801536
RC {ECO:0000313|EMBL:COW22173.1, ECO:0000313|Proteomes:UP000045842},
RC G09901357 {ECO:0000313|EMBL:CFE40400.1,
RC ECO:0000313|Proteomes:UP000048289}, H09601792
RC {ECO:0000313|EMBL:CFE49701.1, ECO:0000313|Proteomes:UP000046947},
RC K00500041 {ECO:0000313|Proteomes:UP000038802}, and P00601463
RC {ECO:0000313|EMBL:COV86524.1, ECO:0000313|Proteomes:UP000048600};
RG Pathogen Informatics;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CFH74529.1, ECO:0000313|Proteomes:UP000046674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0351H {ECO:0000313|EMBL:CFH74529.1,
RC ECO:0000313|Proteomes:UP000046674};
RG Pathogen Informatics;
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:OMH58295.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH58295.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M., Bigi F., Soria M.A.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:OMH58295.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH58295.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M.M., Lopez B., Blanco F.C., Sasiain M.C., De La Barrera S.,
RA Ritacco V., Bigi F., Soria M.A.;
RT "Protein polymorphisms may explain contrasting epidemiological fitness of
RT two variants of a multidrug-resistant Mycobacterium tuberculosis strain.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:QGK77736.1, ECO:0000313|Proteomes:UP000388593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AUSMDU00018547 {ECO:0000313|EMBL:QGK77736.1,
RC ECO:0000313|Proteomes:UP000388593};
RA Baines S.L., Goncalves da Silva A., Carter G.P., Jennison A.V.,
RA Rathnayake I.U., Graham R.M.A., Sintchenko V., Wang Q., Rockett R.J.,
RA Timms V.J., Martinez E., Ballard S., Tomita T., Isles N., Horan K.A.,
RA Pitchers W., Stinear T.P., Williamson D.A., Howden B.P., Seemann T.;
RT "Complete microbial genomes for public health in Australia and Southwest
RT Pacific.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28A subfamily.
CC {ECO:0000256|ARBA:ARBA00005957}.
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DR EMBL; CFOE01000334; CFE40400.1; -; Genomic_DNA.
DR EMBL; CFOH01000204; CFE49701.1; -; Genomic_DNA.
DR EMBL; CFSW01000005; CFH74529.1; -; Genomic_DNA.
DR EMBL; CGCX01000024; CFR64996.1; -; Genomic_DNA.
DR EMBL; CNFT01000142; CKR20190.1; -; Genomic_DNA.
DR EMBL; CNGE01000038; CKR67715.1; -; Genomic_DNA.
DR EMBL; CNFU01000817; CKS56318.1; -; Genomic_DNA.
DR EMBL; CQPW01000050; CNU12297.1; -; Genomic_DNA.
DR EMBL; CSAE01000096; COV35621.1; -; Genomic_DNA.
DR EMBL; CHKL01000057; COV86524.1; -; Genomic_DNA.
DR EMBL; CSAD01000614; COW22173.1; -; Genomic_DNA.
DR EMBL; LWDQ01000001; OMH58295.1; -; Genomic_DNA.
DR EMBL; CP045962; QGK77736.1; -; Genomic_DNA.
DR EMBL; FPTZ01000004; SGH33605.1; -; Genomic_DNA.
DR RefSeq; WP_003402133.1; NZ_WUCS01000008.1.
DR STRING; 115862.BBG46_02290; -.
DR PATRIC; fig|1773.206.peg.4147; -.
DR OMA; PNYEYEV; -.
DR Proteomes; UP000038802; Unassembled WGS sequence.
DR Proteomes; UP000045274; Unassembled WGS sequence.
DR Proteomes; UP000045842; Unassembled WGS sequence.
DR Proteomes; UP000046674; Unassembled WGS sequence.
DR Proteomes; UP000046680; Unassembled WGS sequence.
DR Proteomes; UP000046947; Unassembled WGS sequence.
DR Proteomes; UP000048289; Unassembled WGS sequence.
DR Proteomes; UP000048600; Unassembled WGS sequence.
DR Proteomes; UP000048948; Unassembled WGS sequence.
DR Proteomes; UP000049023; Unassembled WGS sequence.
DR Proteomes; UP000050164; Unassembled WGS sequence.
DR Proteomes; UP000182946; Unassembled WGS sequence.
DR Proteomes; UP000189452; Chromosome.
DR Proteomes; UP000388593; Chromosome.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008235; F:metalloexopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd03876; M28_SGAP_like; 1.
DR CDD; cd04816; PA_SaNapH_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR045175; M28_fam.
DR InterPro; IPR041756; M28_SGAP-like.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR12147; METALLOPEPTIDASE M28 FAMILY MEMBER; 1.
DR PANTHER; PTHR12147:SF55; PEPTIDE HYDROLASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW ECO:0000313|EMBL:CFH74529.1}; Hydrolase {ECO:0000313|EMBL:CFH74529.1};
KW Lipoprotein {ECO:0000313|EMBL:CFH74529.1};
KW Protease {ECO:0000256|ARBA:ARBA00022438, ECO:0000313|EMBL:CFH74529.1}.
FT DOMAIN 140..229
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 252..472
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 500 AA; 52042 MW; CD19BF47D8DB25EF CRC64;
MVNKSRMMPA VLAVAVVVAF LTTGCIRWST QSRPVVNGPA AAEFAVALRN RVSTDAMMAH
LSKLQDIANA NDGTRAVGTP GYQASVDYVV NTLRNSGFDV QTPEFSARVF KAEKGVVTLG
GNTVEARALE YSLGTPPDGV TGPLVAAPAD DSPGCSPSDY DRLPVSGAVV LVDRGVCPFA
QKEDAAAQRG AVALIIADNI DEQAMGGTLG ANTDVKIPVV SVTKSVGFQL RGQSGPTTVK
LTASTQSFKA RNVIAQTKTG SSANVVMAGA HLDSVPEGPG INDNGSGVAA VLETAVQLGN
SPHVSNAVRF AFWGAEEFGL IGSRNYVESL DIDALKGIAL YLNFDMLASP NPGYFTYDGD
QSLPLDARGQ PVVPEGSAGI ERTFVAYLKM AGKTAQDTSF DGRSDYDGFT LAGIPSGGLF
SGAEVKKSAE QAELWGGTAD EPFDPNYHQK TDTLDHIDRT ALGINGAGVA YAVGLYAQDL
GGPNGVPVMA DRTRHLIAKP
//
