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Database: UniProt
Entry: A0A045JJR1_MYCTX
LinkDB: A0A045JJR1_MYCTX
Original site: A0A045JJR1_MYCTX 
ID   A0A045JJR1_MYCTX        Unreviewed;       417 AA.
AC   A0A045JJR1;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   24-JAN-2024, entry version 78.
DE   RecName: Full=Endolytic murein transglycosylase {ECO:0000256|HAMAP-Rule:MF_02065};
DE            EC=4.2.2.- {ECO:0000256|HAMAP-Rule:MF_02065};
DE   AltName: Full=Peptidoglycan polymerization terminase {ECO:0000256|HAMAP-Rule:MF_02065};
GN   Name=yceG {ECO:0000313|EMBL:CFH85353.1};
GN   Synonyms=mltG {ECO:0000256|HAMAP-Rule:MF_02065};
GN   ORFNames=DSI28_09325 {ECO:0000313|EMBL:REM07812.1}, DSI46_14700
GN   {ECO:0000313|EMBL:REM36219.1}, ERS023442_01699
GN   {ECO:0000313|EMBL:CNM36930.1}, ERS053720_02529
GN   {ECO:0000313|EMBL:CFH85353.1}, GJE03_13460
GN   {ECO:0000313|EMBL:QGK79728.1}, SAMEA2683035_01906
GN   {ECO:0000313|EMBL:SGH74286.1};
OS   Mycobacterium tuberculosis.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=1773 {ECO:0000313|EMBL:REM07812.1, ECO:0000313|Proteomes:UP000257078};
RN   [1] {ECO:0000313|Proteomes:UP000045030, ECO:0000313|Proteomes:UP000046674}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=0351H {ECO:0000313|EMBL:CFH85353.1,
RC   ECO:0000313|Proteomes:UP000046674}, and A70144_1
RC   {ECO:0000313|EMBL:CNM36930.1, ECO:0000313|Proteomes:UP000045030};
RG   Pathogen Informatics;
RA   Murphy D.;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:SGH74286.1, ECO:0000313|Proteomes:UP000182946}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2926STDY5723788 {ECO:0000313|EMBL:SGH74286.1,
RC   ECO:0000313|Proteomes:UP000182946};
RG   Pathogen Informatics;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000256389, ECO:0000313|Proteomes:UP000257078}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=30994_S14 {ECO:0000313|EMBL:REM07812.1,
RC   ECO:0000313|Proteomes:UP000257078}, and 31739_S1
RC   {ECO:0000313|EMBL:REM36219.1, ECO:0000313|Proteomes:UP000256389};
RX   PubMed=28099825; DOI=.1056/NEJMoa1604544;
RA   Shah N.S., Auld S.C., Brust J.C., Mathema B., Ismail N., Moodley P.,
RA   Mlisana K., Allana S., Campbell A., Mthiyane T., Morris N., Mpangase P.,
RA   van der Meulen H., Omar S.V., Brown T.S., Narechania A., Shaskina E.,
RA   Kapwata T., Kreiswirth B., Gandhi N.R.;
RT   "Transmission of Extensively Drug-Resistant Tuberculosis in South Africa.";
RL   N. Engl. J. Med. 376:243-253(2017).
RN   [4] {ECO:0000313|EMBL:REM07812.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=30994_S14 {ECO:0000313|EMBL:REM07812.1}, and 31739_S1
RC   {ECO:0000313|EMBL:REM36219.1};
RA   Shah S., Brown T., Auld S., Bratton K., Narechania A., Mathema B.,
RA   Gandhi N.;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:QGK79728.1, ECO:0000313|Proteomes:UP000388593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AUSMDU00018547 {ECO:0000313|EMBL:QGK79728.1,
RC   ECO:0000313|Proteomes:UP000388593};
RA   Baines S.L., Goncalves da Silva A., Carter G.P., Jennison A.V.,
RA   Rathnayake I.U., Graham R.M.A., Sintchenko V., Wang Q., Rockett R.J.,
RA   Timms V.J., Martinez E., Ballard S., Tomita T., Isles N., Horan K.A.,
RA   Pitchers W., Stinear T.P., Williamson D.A., Howden B.P., Seemann T.;
RT   "Complete microbial genomes for public health in Australia and Southwest
RT   Pacific.";
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a peptidoglycan terminase that cleaves nascent
CC       peptidoglycan strands endolytically to terminate their elongation.
CC       {ECO:0000256|HAMAP-Rule:MF_02065}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_02065};
CC       Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_02065}.
CC   -!- SIMILARITY: Belongs to the transglycosylase MltG family.
CC       {ECO:0000256|HAMAP-Rule:MF_02065}.
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DR   EMBL; CFSW01000015; CFH85353.1; -; Genomic_DNA.
DR   EMBL; CQFV01000020; CNM36930.1; -; Genomic_DNA.
DR   EMBL; CP045962; QGK79728.1; -; Genomic_DNA.
DR   EMBL; QSXC01000328; REM07812.1; -; Genomic_DNA.
DR   EMBL; QSXQ01000259; REM36219.1; -; Genomic_DNA.
DR   EMBL; FPTZ01000011; SGH74286.1; -; Genomic_DNA.
DR   RefSeq; WP_003413196.1; NZ_WUCS01000012.1.
DR   PATRIC; fig|1773.206.peg.3055; -.
DR   OMA; TDWDPGP; -.
DR   Proteomes; UP000045030; Unassembled WGS sequence.
DR   Proteomes; UP000046674; Unassembled WGS sequence.
DR   Proteomes; UP000182946; Unassembled WGS sequence.
DR   Proteomes; UP000256389; Unassembled WGS sequence.
DR   Proteomes; UP000257078; Unassembled WGS sequence.
DR   Proteomes; UP000388593; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008932; F:lytic endotransglycosylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd08010; MltG_like; 1.
DR   Gene3D; 3.30.1490.480; Endolytic murein transglycosylase; 1.
DR   HAMAP; MF_02065; MltG; 1.
DR   InterPro; IPR003770; MLTG-like.
DR   PANTHER; PTHR30518:SF2; ENDOLYTIC MUREIN TRANSGLYCOSYLASE; 1.
DR   PANTHER; PTHR30518; UNCHARACTERIZED; 1.
DR   Pfam; PF02618; YceG; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW   Rule:MF_02065};
KW   Cell wall biogenesis/degradation {ECO:0000256|ARBA:ARBA00023316,
KW   ECO:0000256|HAMAP-Rule:MF_02065};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_02065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02065};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW   Rule:MF_02065};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW   Rule:MF_02065}.
FT   TRANSMEM        42..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02065"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..34
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            296
FT                   /note="Important for catalytic activity"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02065"
SQ   SEQUENCE   417 AA;  45474 MW;  889C8561A41F4EDD CRC64;
     MPDGGHRHRA QPVSVRPNRH RRTRVSRAQR RHAQQIRRRR RVAGGFALSL LVVVVVVAVV
     VGAKLWQTML GFGNDYTGPG KRDIVIQIRA GDSTTAVGET LLKHGVVATV RAFVDAAHGN
     TAISSIQPGF YRMRTEISAA SAVARLTDPH NRVGKLVIPE GRQLDDTTDM KTNVVNPGIF
     ALISRATCVD LDGTQRCVSV ADLRAAASRS TPTMLSVPRW AVGPVMELGT DHRRIEGLIA
     PGTFNIDPSA SAETILATLI SAGAVEYMKS GLVDTAKSLG LSPYDILVVA SLVQQEANTQ
     DFPKVARVIY NRLHEHRTLE FDSTVNYPLD RREVATSDTD RAQRTPWNTY MAQGLPATAI
     CSPGVDALRA AEHPVPGDWL YFVTIDSQGT TLFTRDYQQH LANIELAKHN GVLDSAR
//
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