ID A0A059EZZ3_9MICR Unreviewed; 1616 AA.
AC A0A059EZZ3;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN ORFNames=H312_02030 {ECO:0000313|EMBL:KCZ80573.1};
OS Anncaliia algerae PRA339.
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Tubulinosematoidea;
OC Tubulinosematidae; Anncaliia.
OX NCBI_TaxID=1288291 {ECO:0000313|EMBL:KCZ80573.1, ECO:0000313|Proteomes:UP000030655};
RN [1] {ECO:0000313|Proteomes:UP000030655}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PRA339 {ECO:0000313|Proteomes:UP000030655};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Becnel J., Sanscrainte N., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KCZ80573.1, ECO:0000313|Proteomes:UP000030655}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PRA339 {ECO:0000313|EMBL:KCZ80573.1,
RC ECO:0000313|Proteomes:UP000030655};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cuomo C., Becnel J., Sanscrainte N., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Anncaliia algerae insect isolate PRA339.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550,
CC ECO:0000256|RuleBase:RU004279};
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|ARBA:ARBA00006460, ECO:0000256|RuleBase:RU004279}.
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DR EMBL; KK365173; KCZ80573.1; -; Genomic_DNA.
DR STRING; 1288291.A0A059EZZ3; -.
DR VEuPathDB; MicrosporidiaDB:H312_02030; -.
DR HOGENOM; CLU_000487_3_0_1; -.
DR Proteomes; UP000030655; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd02733; RNAP_II_RPB1_N; 1.
DR CDD; cd22541; SP5_N; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.150.390; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.30.1360.140; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 6.20.50.80; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 2.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR007073; RNA_pol_Rpb1_7.
DR InterPro; IPR038593; RNA_pol_Rpb1_7_sf.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF37; DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR Pfam; PF04990; RNA_pol_Rpb1_7; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279};
KW Reference proteome {ECO:0000313|Proteomes:UP000030655};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 205..506
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
FT REGION 1555..1616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1555..1578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1592..1616
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1616 AA; 183864 MW; EDAE9A66024651E3 CRC64;
MQEYTKRINE LLFGLLSPEE TRAMSAVEVK FPETLENGMP KPQGLIDLHM GTIDREYLCL
TCNKDSSTCS GHFGHIELNR PMFHVGFISK IKKVLETICF YCSKIKNKQI DRKIEMTDYF
NKLANRFKLN KIWEINKGKT ICDHCNNKQP LIKKEGLILY VFMKGEENSE GKVMLTGEKV
NSIFKKIEDD EIAKLGFDTK YSRPEWMLIT ALPVCPPCVR PSIAIEGVLR GEDDLTYKYS
DIIKSNQNLK RYEEEGAPSH VIRDYEQLVQ FHVATLMNNE ISGQPQALQK NGRPLKAIST
RIKGKEGRVR GNLMGKRVDF SARSVITPDS NIDLNELGVP IKIAMVHTFP ERVTSFNISK
LTKLVKNGPT IYPGANYVIR KDNQRIDLRF NRSDIALEEG YIVERHMLDG DYVLFNRQPS
LHKMSMMAHR VKVMEGITFR LNLSATSPYN ADFDGDEMNM HMPQSYNSIS ELNCLMSVSQ
NILSPQANKP VIGIVQDTCT GVFRITKKDI FFTEKEFNFI TYNIVSEKNT VKEVKCCILR
PKKLFSGKQL FTSILPEGIN YQRKDVIIQD SQLITGEVCK KVVGTSHGSL IHVLALEKNS
EIVSSFINKL QRLVNSYITY FSSFSVGIGD TIPLDGTSFS INEVIVQSKK EVNSLLKESI
LNKSEKLPGM DLKSAFESKL TLILNKARDV SGNLSINSLR DCNGLKQMVL SGSKGSNINI
SQVTACVGQQ NLEGKRIPFG FNKRALPHFV KDDYSAESKG FVTNSYFTGL NAIEFFFHAI
GGREGLIDTA CKTAETGYIQ RRIVKSLEDA RVNYDGSVRS SSTLYQFKYG NDMFDATYLE
TQGLSKINSH SIENNEIITE KDWLIVKDYL KYYLSVIIEH EDYPGSLYLS DLLNVENNVI
NKDYNLYNNI SLSLPFNVMR LYVNGYVKYK KEKNSFTYYI DKLNQIYKLI KEINYRNNMN
ENFNNKLTNK VTINQKEENK MWIILIRNKF NLKNLLNDRY SLLGLDYVIK EMEHLINRSY
ITMNEMVGTL AAQSIGEPAT QMTLNTFHFA GVAQNVMQGV PRLKELINVV RQIKTPMQKI
YLKNNSLSYV KEIANRIEYT SMSDLVKLVS IIYDPDCTTS VIPEDNDFIQ TYYAFLEENE
DDLGPWVIRI ELYREKLLKK NLLLEYIAET LKKSFKNDIQ IISSDFNAES LVIRIRIKPR
HDELFAKKVM FEILKLHLIG IKGINKCFLL LDDKNKNDKA SKSEEGNLLK ELNQRMRLIT
ENTAEDKDVL SKLKLSDEEG VKEEIRTTLD ESRTENVNVE VTDGWMIQTD GINLRESFLI
DDVDSKSVYC NDLNEIYEVL GVEAVREVIM REIQGVIINS GSYVNARHLS LLADVMTMKG
LRGITRHGVN RASTGVLKRA SFEETVEILL EAACFAEKNF TTGVTESIML GQVSKIGTGS
TELILDMEIL QSVIPLARKY EFLREINTPL ILSPDTITTP NRISMGYSPA TLPGYSPTTP
IYNPTSPVYS PTTPVYSPTS PEYSPTSPVY SPTTPIYSPT SPIYSPTTPV YSPTSPVYIP
QSPKNISKTS QYNPKSPVYK PTSPAYRVTS PKNKTSDKRK LESEEECKRI EKDKDK
//
