ID A0A059F3B5_9MICR Unreviewed; 1244 AA.
AC A0A059F3B5;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN ORFNames=H312_00818 {ECO:0000313|EMBL:KCZ81778.1};
OS Anncaliia algerae PRA339.
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Tubulinosematoidea;
OC Tubulinosematidae; Anncaliia.
OX NCBI_TaxID=1288291 {ECO:0000313|EMBL:KCZ81778.1, ECO:0000313|Proteomes:UP000030655};
RN [1] {ECO:0000313|Proteomes:UP000030655}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PRA339 {ECO:0000313|Proteomes:UP000030655};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Becnel J., Sanscrainte N., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KCZ81778.1, ECO:0000313|Proteomes:UP000030655}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PRA339 {ECO:0000313|EMBL:KCZ81778.1,
RC ECO:0000313|Proteomes:UP000030655};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cuomo C., Becnel J., Sanscrainte N., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Anncaliia algerae insect isolate PRA339.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550,
CC ECO:0000256|RuleBase:RU004279};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|RuleBase:RU004279}.
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DR EMBL; KK365137; KCZ81778.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A059F3B5; -.
DR STRING; 1288291.A0A059F3B5; -.
DR VEuPathDB; MicrosporidiaDB:H312_00818; -.
DR HOGENOM; CLU_000487_3_0_1; -.
DR Proteomes; UP000030655; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.150.390; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF32; DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 2.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000030655};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 177..454
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
SQ SEQUENCE 1244 AA; 142707 MW; 5B8666D0F6F25F52 CRC64;
MKEKLNNSFN YPMEISFIKF QPATNKIIKK LSVHEITKKD LYDSTLKTPL PDGPISQYLG
LSRKDSQCLT CKKGIEDCTG HFGHYNLKAP IFHIGYFKEI YKILKIICKT CASLLEKENS
ICKECKALNG KIKKLNNQRI IYQLSNYIEL LTPERVKSLF TLIKPSLKKK LKMTDPVNLI
IDSICVPPNN IRPSVFVSEE QRNEDDLTIR IAELIYTSEN ISFTKNLAIF LEEKDNLQIA
HNSIITSDKN KGILQRLKGK TGRFRNNLSG KRVDFTGRTV ISPDPNLSVE EVGIPQRIAK
ILTIQERVTQ FNIEDMQKII KLKKANYVIK NEKTLSIRFT PNLTLKIGDI IERHLKNGDI
VLFNRQPSLH RLSIMAHKVR IHKNKTFRFN ECVCTPYNAD FDGDEMNIHV LQSEFARIEA
KILMGVRNNF FSPRNDEPII GAVQDFLTGG YILTSKDTFL TREQFGELIS HFKRKKPCKI
EPTLLRPNKL YTGKSVINFL FSQLNENINL EGKTRNFIKE FHSNDGFLVI NNSKLLFGRI
DKNIIGIESK TNGIFNLLSN ESIKELLDYF AYITSRYLMN KGFSIGIDDV EGNESLIEEK
TNELINCYEN IIKLINKNNK TNDTLEIYDN CDSFMNTEEI NKTNIRNTTI KNNINKLKNI
NEYFDSYLFT NNDLKEKESE ISSLLSKVRE NCGNLCTKYL SFLNAPLIMQ DCGSKGSKIN
VSQMVSCVGQ QIISGSRIPF GFTNRTLPHY HNNLHPKCRG FVSSSFRSGL SEDEFFFHAV
SGREGLVDTA VKTAETGYMQ RRLMKALEDV NLQYDKTVRS DRMIQFEYKE KFSDFFRVYL
QVKNESLNEY KEGTFFNSIK YKFNTLNNES LNDKLTEECE LKWNEFIGNE KSDLFKRIAN
DNLKNEFINR VHSKMKSMEY LSAVGALAGQ SIGEPGTQMT LKTFHFAGVA SMNITLGVPR
IKEIINAVRN INTPIIKANL LFPTLDEAKK VKGRIDKFKL KDIIKSITEI YSNTEMILEV
LLCKESISNL KIEFNIEELR NKIKKDFHCS INDHKITLVS KKEKDKYFIM KELKREIKEI
TISKIKEVKK VVIAQENNLY KLFIEGNGLR EVLCTEGIEY KSTLSNNIVE INEVLGIEAC
RNAIKRELYY TFDSHGIKIN DKHLELLSDV MTNKGLLGIT RFGISKLKSS TLMLASFEQT
GDNLFNSAIK EQKDKLLGVS ESVIVGKRIG FGTGGIKLFL DSKN
//
