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Database: UniProt
Entry: A0A059WAD0_STRA9
LinkDB: A0A059WAD0_STRA9
Original site: A0A059WAD0_STRA9 
ID   A0A059WAD0_STRA9        Unreviewed;       614 AA.
AC   A0A059WAD0;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   25-OCT-2017, entry version 29.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=DC74_4209 {ECO:0000313|EMBL:AIA04691.1};
OS   Streptomyces albulus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=68570 {ECO:0000313|EMBL:AIA04691.1, ECO:0000313|Proteomes:UP000026918};
RN   [1] {ECO:0000313|Proteomes:UP000026918}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NK660 {ECO:0000313|Proteomes:UP000026918};
RA   Gu Y., Yang C., Song C., Wang S., Wang X., Geng W., Sun Y., Feng J.,
RA   Wang Y.;
RT   "Genome Sequence of the epsilon-Poly-L-Lysine-Producing Microorganism
RT   Streptomyces albulus NK660.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP007574; AIA04691.1; -; Genomic_DNA.
DR   EnsemblBacteria; AIA04691; AIA04691; DC74_4209.
DR   KEGG; salu:DC74_4209; -.
DR   PATRIC; fig|68570.5.peg.4499; -.
DR   KO; K02313; -.
DR   Proteomes; UP000026918; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000026918};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000026918}.
FT   DOMAIN      307    435       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      521    590       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     315    322       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   614 AA;  68226 MW;  7BB4E1D012393BA3 CRC64;
     MWPRVLDHLL RSEADGLKPK DQDWLKRTQP LALVADTALL AVPNEFAKGV LEGRLAPLIG
     EALSHECGRP IRIAITVDDS SEEPPALQPA PHQQHAPHQQ PHQQPQHEAY DGYDGRHDSR
     QGYGHQGDDL PSVRPAYPDY PQHRHEPGAW PQHSRTDAVG PREEYGWQQQ HLGGYPDRET
     STEQWREPYG SPPAHLQQHQ NDYRSQGPDR GGPRPSDGPR SPYEQQRRDH SELPPPGPGG
     RPGGPGSLPA PSGAPGPLAA QPAPATGPGE PTARLNPKYL FDTFVIGASN RFAHAAAVAV
     AEAPAKAYNP LFIYGESGLG KTHLLHAIGH YARSLYPGTR VRYVSSEEFT NEFINSIRDG
     KADAFRKRYR DMDILLVDDI QFLASKESTQ EEFFHTFNTL HNANKQIVLS SDRPPKQLVT
     LEDRLRNRFE WGLITDVQPP ELETRIAILR KKAVQEQLNA PPEVLEFIAS RISRNIRELE
     GALIRVTAFA SLNRQPVDLG LTEIVLKDLI PGGEDTAPEI TATAIMASTA DYFGLTVDDL
     CGSSRSRVLV TARQIAMYLC RELTDLSLPK IGAQFGGRDH TTVMHADRKI RALMAERRSI
     YNQVTELTNR IKNG
//
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