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Database: UniProt
Entry: A0A060BBL1_9GAMM
LinkDB: A0A060BBL1_9GAMM
Original site: A0A060BBL1_9GAMM 
ID   A0A060BBL1_9GAMM        Unreviewed;       488 AA.
AC   A0A060BBL1;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   05-JUL-2017, entry version 26.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=FF32_06265 {ECO:0000313|EMBL:AIA74466.1};
OS   Halomonas campaniensis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=213554 {ECO:0000313|EMBL:AIA74466.1, ECO:0000313|Proteomes:UP000027249};
RN   [1] {ECO:0000313|EMBL:AIA74466.1, ECO:0000313|Proteomes:UP000027249}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LS21 {ECO:0000313|EMBL:AIA74466.1,
RC   ECO:0000313|Proteomes:UP000027249};
RA   Haitao Y., Guo-Qiang C.;
RT   "A Seawater Based Open and Continuous Process for
RT   Polyhydroxyalkanoates Production by Recombinant Halomonas campaniensis
RT   LS21 Grown in Mixed Substrates.";
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP007757; AIA74466.1; -; Genomic_DNA.
DR   RefSeq; WP_038479938.1; NZ_CP007757.1.
DR   EnsemblBacteria; AIA74466; AIA74466; FF32_06265.
DR   GeneID; 32424429; -.
DR   KEGG; hcs:FF32_06265; -.
DR   KO; K02313; -.
DR   Proteomes; UP000027249; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000027249};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897}.
FT   DOMAIN      185    376       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      396    465       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     193    200       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      465    488       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   488 AA;  54976 MW;  E05F6CF709AC0023 CRC64;
     MSLALWQQCL DYLQDELNSQ QFNTWIRPLQ AEEGETNELR LLAPNRFVRD WVSDKYSKRI
     SELMRELAPS KPPKVSLTVG SRRVAAPAPQ PRDLGNPVSA SPSRQASPAV HTPPRGDLAD
     EREIDQLREE SPNRRGNERQ VQVEGSLKHG SGLNPNFTFD TFVEGKSNQL ARAASRQVSE
     NPGGAYNPLF LYGGVGLGKT HLMHAVGNAL AGRRENARVV YLHSERFVAD MVKALQLNAI
     NDFKRFYRSV DALLIDDIQF FAGKERSQEE FFHTFNALLE GGQQMILTSD RYPKEISGVE
     ERLKSRFGWG LTVAIEPPEL ETRVAILMKK ADQAKVDLPH DAAFFIAQKI RSNVRELEGA
     LKKVIADSHF MGKTITQDFI RESLKDLLAL QDKQVGVDNI QRTVAEYYKI KVADLLSKRR
     SRSVARPRQV AMALAKELTN HSLPEIGDAF GGRDHTTVLH ACRKVKALQE ENADIREDYK
     NLLRLLTS
//
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