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Database: UniProt
Entry: A0A060LZ26_9BACI
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ID   A0A060LZ26_9BACI        Unreviewed;       455 AA.
AC   A0A060LZ26;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   25-OCT-2017, entry version 24.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378};
GN   ORFNames=BleG1_2444 {ECO:0000313|EMBL:AIC95020.1};
OS   Bacillus lehensis G1.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1246626 {ECO:0000313|EMBL:AIC95020.1, ECO:0000313|Proteomes:UP000027142};
RN   [1] {ECO:0000313|EMBL:AIC95020.1, ECO:0000313|Proteomes:UP000027142}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G1 {ECO:0000313|EMBL:AIC95020.1,
RC   ECO:0000313|Proteomes:UP000027142};
RX   PubMed=24811681; DOI=10.1016/j.gene.2014.05.012;
RA   Noor Y.M., Samsulrizal N.H., Jema'on N.A., Low K.O., Ramli A.N.,
RA   Alias N.I., Damis S.I., Fuzi S.F., Isa M.N., Murad A.M., Raih M.F.,
RA   Bakar F.D., Najimudin N., Mahadi N.M., Illias R.M.;
RT   "A comparative genomic analysis of the alkalitolerant soil bacterium
RT   Bacillus lehensis G1.";
RL   Gene 545:253-261(2014).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723548}.
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DR   EMBL; CP003923; AIC95020.1; -; Genomic_DNA.
DR   RefSeq; WP_051667559.1; NZ_CP003923.1.
DR   EnsemblBacteria; AIC95020; AIC95020; BleG1_2444.
DR   KEGG; ble:BleG1_2444; -.
DR   PATRIC; fig|1246626.3.peg.2443; -.
DR   KO; K03601; -.
DR   Proteomes; UP000027142; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000027142};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723511};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723558};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723518};
KW   Reference proteome {ECO:0000313|Proteomes:UP000027142}.
FT   DOMAIN        4     99       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      122    435       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
FT   COILED      263    290       {ECO:0000256|SAM:Coils}.
FT   COILED      305    332       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   455 AA;  52305 MW;  E9853049A8C67082 CRC64;
     MEAWSVSEAT RYIKRLIEND TQLMEVWIRG ELSNVKRHSR GHLYFTVKDA NARMQSVMFA
     GYNQHLRFIP ENGMKVLIRG EVNVYEPYGQ YQFYAKEMQP DGIGSLHVAF ERLKKQLEQE
     GLFAAERKKP LPSYPRHIAV ITSQTGAVIR DIMTTLKRRM PNIRVTLFPV AVQGHLAIDS
     IERALVQANQ AALFDLIIVG RGGGSMEELW AFNEERVARA IGSSTIPVIS AVGHETDYTI
     SDFVADLRAP TPTAAAEFAV PDVREQLRQV DHYKQRMVRA MRQMAEKKRA QLQYAKRSYA
     FRYPRQLVEQ KEQQLDQAVE RMNREMQRFA KEKRSSYTSI QHRLLRHHPE TAAVLKKKEL
     NVLDHRLGQA LNKQVTVKRN QLTSLLAQLE LLSPLKIMNR GYSLVYNEAE NKLVKSVDEL
     KENHDVRLLF KDGRATGVIK EIIHEGVDQS GQSKE
//
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