ID A0A061DC65_BABBI Unreviewed; 569 AA.
AC A0A061DC65;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=indole-3-glycerol-phosphate synthase {ECO:0000256|ARBA:ARBA00012362};
DE EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362};
GN ORFNames=BBBOND_0205180 {ECO:0000313|EMBL:CDR95360.1};
OS Babesia bigemina.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=5866 {ECO:0000313|EMBL:CDR95360.1, ECO:0000313|Proteomes:UP000033188};
RN [1] {ECO:0000313|Proteomes:UP000033188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bond {ECO:0000313|Proteomes:UP000033188};
RA Aslett M., De Silva N.;
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001633};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 4/5. {ECO:0000256|ARBA:ARBA00004696}.
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DR EMBL; LK391708; CDR95360.1; -; Genomic_DNA.
DR RefSeq; XP_012767546.1; XM_012912092.1.
DR AlphaFoldDB; A0A061DC65; -.
DR STRING; 5866.A0A061DC65; -.
DR EnsemblProtists; CDR95360; CDR95360; BBBOND_0205180.
DR GeneID; 24563901; -.
DR KEGG; bbig:BBBOND_0205180; -.
DR VEuPathDB; PiroplasmaDB:BBBOND_0205180; -.
DR OMA; HPIQIAQ; -.
DR OrthoDB; 230791at2759; -.
DR UniPathway; UPA00035; UER00043.
DR Proteomes; UP000033188; Chromosome 2.
DR GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR22854:SF2; INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR22854; TRYPTOPHAN BIOSYNTHESIS PROTEIN; 1.
DR Pfam; PF00218; IGPS; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000033188};
KW Signal {ECO:0000256|SAM:SignalP};
KW Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..569
FT /note="indole-3-glycerol-phosphate synthase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001600258"
FT DOMAIN 68..335
FT /note="Indole-3-glycerol phosphate synthase"
FT /evidence="ECO:0000259|Pfam:PF00218"
SQ SEQUENCE 569 AA; 65348 MW; B295AE1F41CC0BBC CRC64;
MSITYRLIVI AQSLLIHAYC HGSSRFSTCR SHLYGYGFTS SPKSRFNGSL RAAGDESLRY
KAEERFYKII ADKHAQVERL LDDHKDPNDP LQLRLKFVEC TANHKLGEML RRHSTEQGHG
LSVIADMKRR TPTQHHTLDN SVLSFLDASD VAKSMASQIY FNVQHWFDVI FVNTDETVYG
GHISELHACF LELRKLGRRI RPAIVMKDIV IHPIQIAQAA EYRADGVLLN ASVLGNTLKE
MIIACLNMGI EPIVEIHTKE EAMLALEFGA NNLLVNQWDR VHNFLRPTRA LEIKNIIGDE
ATLIAAGGII NFAQVHELAL MGYDAVVLGR RLSYDDTPEF VERIRQWQAP CKSILRLSKD
MFFDIHDEGV ARTIKLKRNH EKLLNEMNVF YGRKGVDVSN IMKANQESDA LPKEPTHQQS
FVNNQYCNDG DDIGDTIVTV TYGNPAQTTF VRNILSTVEC PESRIDTNKY LTERKSEMYR
MKWYVERQRW VRRFRHHFQN RRDANNAHRL KKAIEMYTAF LLYGAQLLKS KKSNVCVEEI
GQILRQNVKA AYEEAPRDNL GNIIMPRPE
//
