UniProt: A0A061DIL5

Database: UniProt
Entry: A0A061DIL5_THECC

LinkDB:  A0A061DIL5_THECC 
Original site:  A0A061DIL5_THECC

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Ontology (7)   
   GO (7)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (8)   
   InterPro (5)   
   Pfam (2)   
   PROSITE (1)   
Literature (1)   
   PubMed (1)   
All databases (21)   

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ID   A0A061DIL5_THECC        Unreviewed;      1096 AA.
AC   A0A061DIL5;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   24-JAN-2024, entry version 56.
DE   RecName: Full=Cellulose synthase {ECO:0000256|RuleBase:RU361116};
DE            EC=2.4.1.12 {ECO:0000256|RuleBase:RU361116};
GN   ORFNames=TCM_001310 {ECO:0000313|EMBL:EOX92360.1};
OS   Theobroma cacao (Cacao) (Cocoa).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Malvales; Malvaceae; Byttnerioideae; Theobroma.
OX   NCBI_TaxID=3641 {ECO:0000313|EMBL:EOX92360.1, ECO:0000313|Proteomes:UP000026915};
RN   [1] {ECO:0000313|EMBL:EOX92360.1, ECO:0000313|Proteomes:UP000026915}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Matina 1-6 {ECO:0000313|Proteomes:UP000026915};
RX   PubMed=23731509; DOI=10.1186/gb-2013-14-6-r53;
RA   Motamayor J.C., Mockaitis K., Schmutz J., Haiminen N., Iii D.L.,
RA   Cornejo O., Findley S.D., Zheng P., Utro F., Royaert S., Saski C.,
RA   Jenkins J., Podicheti R., Zhao M., Scheffler B.E., Stack J.C., Feltus F.A.,
RA   Mustiga G.M., Amores F., Phillips W., Marelli J.P., May G.D., Shapiro H.,
RA   Ma J., Bustamante C.D., Schnell R.J., Main D., Gilbert D., Parida L.,
RA   Kuhn D.N.;
RT   "The genome sequence of the most widely cultivated cacao type and its use
RT   to identify candidate genes regulating pod color.";
RL   Genome Biol. 14:R53.1-R53.24(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-
CC         beta-D-glucosyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:19929, Rhea:RHEA-
CC         COMP:10033, Rhea:RHEA-COMP:10034, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:18246, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00000122,
CC         ECO:0000256|RuleBase:RU361116};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361116};
CC       Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000256|RuleBase:RU361116};
CC   -!- PATHWAY: Glycan metabolism; plant cellulose biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004768, ECO:0000256|RuleBase:RU361116}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC       ECO:0000256|RuleBase:RU361116}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361116}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. Plant
CC       cellulose synthase subfamily. {ECO:0000256|ARBA:ARBA00007548,
CC       ECO:0000256|RuleBase:RU361116}.
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DR   EMBL; CM001879; EOX92360.1; -; Genomic_DNA.
DR   RefSeq; XP_017982127.1; XM_018126638.1.
DR   AlphaFoldDB; A0A061DIL5; -.
DR   SMR; A0A061DIL5; -.
DR   STRING; 3641.A0A061DIL5; -.
DR   EnsemblPlants; EOX92360; EOX92360; TCM_001310.
DR   EnsemblPlants; Tc01v2_t010160.1; Tc01v2_p010160.1; Tc01v2_g010160.
DR   GeneID; 18611727; -.
DR   Gramene; EOX92360; EOX92360; TCM_001310.
DR   Gramene; Tc01v2_t010160.1; Tc01v2_p010160.1; Tc01v2_g010160.
DR   KEGG; tcc:18611727; -.
DR   eggNOG; ENOG502QQGG; Eukaryota.
DR   HOGENOM; CLU_001418_0_0_1; -.
DR   InParanoid; A0A061DIL5; -.
DR   OMA; VYCIPKL; -.
DR   OrthoDB; 1210919at2759; -.
DR   UniPathway; UPA00695; -.
DR   Proteomes; UP000026915; Chromosome 1.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016760; F:cellulose synthase (UDP-forming) activity; IEA:UniProtKB-EC.
DR   GO; GO:0016759; F:cellulose synthase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0030244; P:cellulose biosynthetic process; IBA:GO_Central.
DR   GO; GO:0009833; P:plant-type primary cell wall biogenesis; IBA:GO_Central.
DR   CDD; cd16617; mRING-HC-C4C4_CesA; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR005150; Cellulose_synth.
DR   InterPro; IPR027934; CES_Znf_RING.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13301:SF167; CELLULOSE SYNTHASE A CATALYTIC SUBUNIT 9 [UDP-FORMING]-RELATED; 1.
DR   PANTHER; PTHR13301; X-BOX TRANSCRIPTION FACTOR-RELATED; 1.
DR   Pfam; PF03552; Cellulose_synt; 1.
DR   Pfam; PF14569; zf-UDP; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU361116};
KW   Cell wall biogenesis/degradation {ECO:0000256|RuleBase:RU361116};
KW   Cellulose biosynthesis {ECO:0000256|ARBA:ARBA00022916,
KW   ECO:0000256|RuleBase:RU361116};
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000256|RuleBase:RU361116}; Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361116};
KW   Metal-binding {ECO:0000256|RuleBase:RU361116};
KW   Reference proteome {ECO:0000313|Proteomes:UP000026915};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361116};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361116};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361116};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361116};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361116"
FT   TRANSMEM        314..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361116"
FT   TRANSMEM        874..894
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361116"
FT   TRANSMEM        906..924
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361116"
FT   TRANSMEM        944..964
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361116"
FT   TRANSMEM        985..1006
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361116"
FT   TRANSMEM        1026..1044
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361116"
FT   TRANSMEM        1056..1076
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361116"
FT   DOMAIN          39..85
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          135..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1096 AA;  123593 MW;  D41B6E6C894BE915 CRC64;
     MDTGGRLIAG SHNRNEFVLI NADENGRIKS VQELSGQTCQ ICGDEIEITV DGEPFVACNE
     CAFPVCRPCY EYERREGNQA CPQCKTRYKR IKGSPRVEGD EEEDDIDDLD NEFDYDALDP
     HQVAEAMLTA RLNTGRGSHP NTSGIPTHSE LDSSPPSSQI PLLTYGEEGS EISADHHALI
     VPPFMGHGNR VHPMPYTDPS VPLQPRPMVP EKDIAVYGYG SVAWKDRMEE WKKRQNDKLQ
     VVKHEGGNDG GNFDGEGLDD ADLPMMDEGR QPLSRKLPIP SSKINPYRLI IILRLAILGL
     FFHYRLLHPV RDAYGLWLTS VICEIWFAVS WILDQFPKWY PIERETYLDR LSLRYEKEGK
     PSELASIDIF VSTVDPMKEP PLITANTVLS ILAVDYPVDK VACYVSDDGA AMLTFEALSE
     TSEFARKWVP FCKKFNIEPR APEWYFSQKI DYLKNKVHPA FVRERRAMKR EYEEFKVRIN
     GLVATAQKVP EEGWTMQDGT PWPGNNVRDH PGMIQVFLGH SGVCDVEGNE LPRLVYVSRE
     KRPGFEHHKK AGAMNALIRV SAVLSNAPYL LNVDCDHYIN NSKALREAMC FMMDPTSGKK
     VCYVQFPQRF DGIDRHDRYS NRNVVFFDIN MKGLDGIQGP IYVGTGCVFR RQALYGYDAP
     VTKKPPGKTC NCLPKWCYCL CCCSRKNKKT KRKEKTKKSK QREASKQIHA LENIEEGISE
     ANSQKSSETS QMKLEKKFGQ SPVFVASTLL EDGGVPQNAS PASLLREAIQ VISCGYEDKT
     EWGKEVGWIY GSVTEDILTG FKMHCHGWRS VYCIPKRPAF KGSAPINLSD RLHQVLRWAL
     GSVEIFLSRH CPIWYGYGGG LKWLERFSYI NSVVYPWTSI PLLVYCTLPA ICLLTGKFIV
     PEISNYASLI FIALFISIAA TSIIEMQWGG VGIDDWWRNE QFWVIGGVSS HLFALFQGLL
     KVLAGVSTSF TVTSKGADDG EFSELYLFKW TSLLIPPTTL LIINIVGVVV GVSDAINNGY
     DSWGPLFGRL FFALWVIIHL YPFLKGLLGK QDRMPTIILV WSILLASILT LMWVRINPFV
     SKDGPVLEVC GLNCDD
//

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