ID A0A061EA69_THECC Unreviewed; 1706 AA.
AC A0A061EA69;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Menaquinone biosynthesis protein, putative isoform 2 {ECO:0000313|EMBL:EOY01528.1};
GN ORFNames=TCM_011392 {ECO:0000313|EMBL:EOY01528.1};
OS Theobroma cacao (Cacao) (Cocoa).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Byttnerioideae; Theobroma.
OX NCBI_TaxID=3641 {ECO:0000313|EMBL:EOY01528.1, ECO:0000313|Proteomes:UP000026915};
RN [1] {ECO:0000313|EMBL:EOY01528.1, ECO:0000313|Proteomes:UP000026915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Matina 1-6 {ECO:0000313|Proteomes:UP000026915};
RX PubMed=23731509; DOI=10.1186/gb-2013-14-6-r53;
RA Motamayor J.C., Mockaitis K., Schmutz J., Haiminen N., Iii D.L.,
RA Cornejo O., Findley S.D., Zheng P., Utro F., Royaert S., Saski C.,
RA Jenkins J., Podicheti R., Zhao M., Scheffler B.E., Stack J.C., Feltus F.A.,
RA Mustiga G.M., Amores F., Phillips W., Marelli J.P., May G.D., Shapiro H.,
RA Ma J., Bustamante C.D., Schnell R.J., Main D., Gilbert D., Parida L.,
RA Kuhn D.N.;
RT "The genome sequence of the most widely cultivated cacao type and its use
RT to identify candidate genes regulating pod color.";
RL Genome Biol. 14:R53.1-R53.24(2013).
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DR EMBL; CM001880; EOY01528.1; -; Genomic_DNA.
DR EnsemblPlants; EOY01528; EOY01528; TCM_011392.
DR Gramene; EOY01528; EOY01528; TCM_011392.
DR HOGENOM; CLU_001622_0_0_1; -.
DR Proteomes; UP000026915; Chromosome 2.
DR GO; GO:0070204; F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity; IEA:InterPro.
DR GO; GO:0070205; F:2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0009063; P:amino acid catabolic process; IEA:InterPro.
DR GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd07037; TPP_PYR_MenD; 1.
DR CDD; cd02009; TPP_SHCHC_synthase; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR Gene3D; 3.30.390.10; Enolase-like, N-terminal domain; 1.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR HAMAP; MF_01659; MenD; 1.
DR HAMAP; MF_01660; MenH; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR036849; Enolase-like_C_sf.
DR InterPro; IPR029017; Enolase-like_N.
DR InterPro; IPR029065; Enolase_C-like.
DR InterPro; IPR018110; Mandel_Rmase/mucon_lact_enz_CS.
DR InterPro; IPR013342; Mandelate_racemase_C.
DR InterPro; IPR004433; MenaQ_synth_MenD.
DR InterPro; IPR032264; MenD_middle.
DR InterPro; IPR022485; SHCHC_synthase_MenH.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; TIGR01927; menC_gam_Gplu; 1.
DR NCBIfam; TIGR00173; menD; 1.
DR PANTHER; PTHR42916; 2-SUCCINYL-5-ENOLPYRUVYL-6-HYDROXY-3-CYCLOHEXENE-1-CARBOXYLATE SYNTHASE; 1.
DR PANTHER; PTHR42916:SF1; PROTEIN PHYLLO, CHLOROPLASTIC; 1.
DR Pfam; PF12697; Abhydrolase_6; 1.
DR Pfam; PF13378; MR_MLE_C; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF16582; TPP_enzyme_M_2; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SFLD; SFLDS00001; Enolase; 1.
DR SFLD; SFLDF00009; o-succinylbenzoate_synthase; 1.
DR SMART; SM00922; MR_MLE; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00909; MR_MLE_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Menaquinone biosynthesis {ECO:0000256|ARBA:ARBA00022428};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000026915};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1158..1254
FT /note="Mandelate racemase/muconate lactonizing enzyme C-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM00922"
SQ SEQUENCE 1706 AA; 188880 MW; 423711BA9E63883A CRC64;
MLSLRDTLSI PFLALTPKPH LKNHLFHTKN PTPYTRLPLF CKKDFLSCNL KLVNGVRFDG
PIIDANELED GDLVVETCIT HTLPPALTLE HGLQSIKEAV DALKLNPPCS SSGVLRFQVA
VPPSAKALNW FCSQPESSAV FPLFFLSKEM NRSTCKSLYL NTARGVFGIG AAVSFTNSSS
VPGELSSIKR CLSNDSIPMS TYGFLDINFN TELSSVKLEA GSFYLFIPLI ELDEHEDISI
LAATLAWSDS CLCTFEQAIH SYESALYQVS SHFSPTTERC HFKCIRSAIR KLNVVEDGAV
QMVYMNALSM GGRDFGAYPM DLRGAASFNQ FCFKFTPTIG VACNMLDNAS EMTYSVPDRA
NINAVWALLI VEECSRLGLT YFCVAPGSRS SPLALAASAH PLVTCISCFD ERSLAFHAIG
YARGSQKAAV IITTSGTAVS NLLPAVVEAS QDFVPLLVLS ADRPPELQDC GANQSINQVN
HFGSFVRFFF SLPPPTDEIP ARMVLTTLDS AVHRATSSPI GPVHINCPFR EPLDDSPKIW
KSSCLEGLDT WMSNAEPFTK YILVQHSYLC NNNTHGQMEE VLEKIQGVNK GLLLIGAICT
EDEMWAVLLL AKNLQWPVVV DILSGLRLRR LLSSFLEVEE NIFFVDYLDH ALLSDSVRDW
VQFDVIVQIG SRITSKRISQ MLEKCFPCSY ILVDNHPCRH DPSHFVTHRI QSSAIEFANI
LLKARIPHRS SKWCGYLQAL NMMVGQEILF QVSAEHSLSE PHIAHVISEA LSSETALFIG
NSMVIRDADM YGCNWKSDNH SIADMMLKTE LPCKWVSVAG NRGASGIDGL LSTAIGFAVG
CNKRVLCVVG DISFLHDTNG LAILKQRMLR KPMTILVINN GGGAIFSLLP IADITEPRVL
NQYFYTSHNI SIQKLCEAHG VKHLEVKTKM ELHEALFSSQ QGETDCVIEV ESSIDANATF
HSYLRKFACQ AADHSFSILS KLSLPESMSQ GCFHCKIHSM SYSLYRIPLC APPTSSLSDS
DRTRFYREGF ILSLTLEDGS IGYGEVAPLE ICHENLLDVE EQLRFLFHVL QGATINYFLP
MLKSSFSSWI WKNLGIPACS LFPSVRCGLE MAILNAIAVS QGMTLLNILH PQGAKEGEKS
ERLPSVRICG LINSSGTPEE VACIANALVE EGFTAIKIKV ARRADPVEDA AVIQEVRKKV
GCHIELRVDA NRNWTYEEAI QFGCLVKDCN LQYIEEPVQH EDDIIRYCEE SGLPVALDET
IDNCPENPLN KLVKYSHPRI VAVVIKPTVI GGFEKAAMFA RWAHRRGKMA IISAAFESGL
ALSTYILFSC YVEMQNADTC KLMNNKLAPS VAHGLGTYRW LEEDVTADLL GIGPNPCTGF
IEASVADATH LLHKFQMNNN VVHRMFTAEE VLRYQITLDS NDFSCSINVQ EIGQRNDGSV
IVFLHGFLGT NQDWDRIMHA ISGSARCISV DLPGHGVTKM NLFDDKAAQQ PTLSMELVAD
LLFKLIERIT PGKVTLVGYS MGARIALYMA LRFSDKIEGA VILSGSPGLE DAVERKICRA
KDDSRACSLG THGLQLFLDT WYSGGLWKSL RSHPHFNQIA ARRSLHDDVQ GLARVLSDLS
AGRQPSLWED LKHCRTPLVL VVGEEDEKFK GVAQKMWKEI GHVSKLHEMV VVPNCGHAVH
LENPLPIIRL VRQFLTRLKS DPSSKK
//