ID A0A061EAU2_THECC Unreviewed; 1770 AA.
AC A0A061EAU2;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE SubName: Full=Menaquinone biosynthesis protein, putative isoform 1 {ECO:0000313|EMBL:EOY01527.1};
GN ORFNames=TCM_011392 {ECO:0000313|EMBL:EOY01527.1};
OS Theobroma cacao (Cacao) (Cocoa).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Byttnerioideae; Theobroma.
OX NCBI_TaxID=3641 {ECO:0000313|EMBL:EOY01527.1, ECO:0000313|Proteomes:UP000026915};
RN [1] {ECO:0000313|EMBL:EOY01527.1, ECO:0000313|Proteomes:UP000026915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Matina 1-6 {ECO:0000313|Proteomes:UP000026915};
RX PubMed=23731509; DOI=10.1186/gb-2013-14-6-r53;
RA Motamayor J.C., Mockaitis K., Schmutz J., Haiminen N., Iii D.L.,
RA Cornejo O., Findley S.D., Zheng P., Utro F., Royaert S., Saski C.,
RA Jenkins J., Podicheti R., Zhao M., Scheffler B.E., Stack J.C., Feltus F.A.,
RA Mustiga G.M., Amores F., Phillips W., Marelli J.P., May G.D., Shapiro H.,
RA Ma J., Bustamante C.D., Schnell R.J., Main D., Gilbert D., Parida L.,
RA Kuhn D.N.;
RT "The genome sequence of the most widely cultivated cacao type and its use
RT to identify candidate genes regulating pod color.";
RL Genome Biol. 14:R53.1-R53.24(2013).
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DR EMBL; CM001880; EOY01527.1; -; Genomic_DNA.
DR STRING; 3641.A0A061EAU2; -.
DR EnsemblPlants; EOY01527; EOY01527; TCM_011392.
DR Gramene; EOY01527; EOY01527; TCM_011392.
DR eggNOG; KOG1223; Eukaryota.
DR eggNOG; KOG2382; Eukaryota.
DR InParanoid; A0A061EAU2; -.
DR OMA; RKWTYEQ; -.
DR Proteomes; UP000026915; Chromosome 2.
DR GO; GO:0070204; F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity; IEA:InterPro.
DR GO; GO:0070205; F:2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0009063; P:amino acid catabolic process; IEA:InterPro.
DR GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd07037; TPP_PYR_MenD; 1.
DR CDD; cd02009; TPP_SHCHC_synthase; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR Gene3D; 3.30.390.10; Enolase-like, N-terminal domain; 1.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR HAMAP; MF_01659; MenD; 1.
DR HAMAP; MF_01660; MenH; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR036849; Enolase-like_C_sf.
DR InterPro; IPR029017; Enolase-like_N.
DR InterPro; IPR029065; Enolase_C-like.
DR InterPro; IPR018110; Mandel_Rmase/mucon_lact_enz_CS.
DR InterPro; IPR013342; Mandelate_racemase_C.
DR InterPro; IPR004433; MenaQ_synth_MenD.
DR InterPro; IPR032264; MenD_middle.
DR InterPro; IPR022485; SHCHC_synthase_MenH.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; TIGR01927; menC_gam_Gplu; 1.
DR NCBIfam; TIGR00173; menD; 1.
DR PANTHER; PTHR42916; 2-SUCCINYL-5-ENOLPYRUVYL-6-HYDROXY-3-CYCLOHEXENE-1-CARBOXYLATE SYNTHASE; 1.
DR PANTHER; PTHR42916:SF1; PROTEIN PHYLLO, CHLOROPLASTIC; 1.
DR Pfam; PF12697; Abhydrolase_6; 1.
DR Pfam; PF13378; MR_MLE_C; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF16582; TPP_enzyme_M_2; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SFLD; SFLDG00180; muconate_cycloisomerase; 1.
DR SFLD; SFLDF00009; o-succinylbenzoate_synthase; 1.
DR SMART; SM00922; MR_MLE; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00909; MR_MLE_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Menaquinone biosynthesis {ECO:0000256|ARBA:ARBA00022428};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000026915};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1222..1318
FT /note="Mandelate racemase/muconate lactonizing enzyme C-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM00922"
SQ SEQUENCE 1770 AA; 196497 MW; 53B5DA991796A881 CRC64;
MLSLRDTLSI PFLALTPKPH LKNHLFHTKN PTPYTRLPLF CKKDFLSCNL KLVNGVRFDG
PIIDANELED GDLVVETCIT HTLPPALTLE HGLQSIKEAV DALKLNPPCS SSGVLRFQVA
VPPSAKALNW FCSQPESSAV FPLFFLSKEM NRSTCKSLYL NTARGVFGIG AAVSFTNSSS
VPGELSSIKR CLSNDSIPMS TYGFLDINFN TELSSVKLEA GSFYLFIPLI ELDEHEDISI
LAATLAWSDS CLCTFEQAIH SYESALYQVS SHFSPTTERC HFKCIRSAIR KLNVVEDGAV
QMVCIPHCAF PFYFPKFCLV YRFLFGFNDL DFLLPELLIF ASLRMLTNFS SCKVDFDMVM
CIHECSFDGW KGFWSLPHGS GISFFLRGAA SFNQFCFKFT PTIGVACNML DNASEMTYSV
PDRANINAVW ALLIVEECSR LGLTYFCVAP GSRSSPLALA ASAHPLVTCI SCFDERSLAF
HAIGYARGSQ KAAVIITTSG TAVSNLLPAV VEASQDFVPL LVLSADRPPE LQDCGANQSI
NQVNHFGSFV RFFFSLPPPT DEIPARMVLT TLDSAVHRAT SSPIGPVHIN CPFREPLDDS
PKIWKSSCLE GLDTWMSNAE PFTKYILVQH SYLCNNNTHG QMEEVLEKIQ GVNKGLLLIG
AICTEDEMWA VLLLAKNLQW PVVVDILSGL RLRRLLSSFL EVEENIFFVD YLDHALLSDS
VRDWVQFDVI VQIGSRITSK RISQMLEKCF PCSYILVDNH PCRHDPSHFV THRIQSSAIE
FANILLKARI PHRSSKWCGY LQALNMMVGQ EILFQVSAEH SLSEPHIAHV ISEALSSETA
LFIGNSMVIR DADMYGCNWK SDNHSIADMM LKTELPCKWV SVAGNRGASG IDGLLSTAIG
FAVGCNKRVL CVVGDISFLH DTNGLAILKQ RMLRKPMTIL VINNGGGAIF SLLPIADITE
PRVLNQYFYT SHNISIQKLC EAHGVKHLEV KTKMELHEAL FSSQQGETDC VIEVESSIDA
NATFHSYLRK FACQAADHSF SILSKLSLPE SMSQGCFHCK IHSMSYSLYR IPLCAPPTSS
LSDSDRTRFY REGFILSLTL EDGSIGYGEV APLEICHENL LDVEEQLRFL FHVLQGATIN
YFLPMLKSSF SSWIWKNLGI PACSLFPSVR CGLEMAILNA IAVSQGMTLL NILHPQGAKE
GEKSERLPSV RICGLINSSG TPEEVACIAN ALVEEGFTAI KIKVARRADP VEDAAVIQEV
RKKVGCHIEL RVDANRNWTY EEAIQFGCLV KDCNLQYIEE PVQHEDDIIR YCEESGLPVA
LDETIDNCPE NPLNKLVKYS HPRIVAVVIK PTVIGGFEKA AMFARWAHRR GKMAIISAAF
ESGLALSTYI LFSCYVEMQN ADTCKLMNNK LAPSVAHGLG TYRWLEEDVT ADLLGIGPNP
CTGFIEASVA DATHLLHKFQ MNNNVVHRMF TAEEVLRYQI TLDSNDFSCS INVQEIGQRN
DGSVIVFLHG FLGTNQDWDR IMHAISGSAR CISVDLPGHG VTKMNLFDDK AAQQPTLSME
LVADLLFKLI ERITPGKVTL VGYSMGARIA LYMALRFSDK IEGAVILSGS PGLEDAVERK
ICRAKDDSRA CSLGTHGLQL FLDTWYSGGL WKSLRSHPHF NQIAARRSLH DDVQGLARVL
SDLSAGRQPS LWEDLKHCRT PLVLVVGEED EKFKGVAQKM WKEIGHVSKL HEMVVVPNCG
HAVHLENPLP IIRLVRQFLT RLKSDPSSKK
//