ID A0A061EJW6_THECC Unreviewed; 1316 AA.
AC A0A061EJW6;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=DNA repair-recombination protein (RAD50) isoform 1 {ECO:0000313|EMBL:EOY05146.1};
GN ORFNames=TCM_020229 {ECO:0000313|EMBL:EOY05146.1};
OS Theobroma cacao (Cacao) (Cocoa).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Byttnerioideae; Theobroma.
OX NCBI_TaxID=3641 {ECO:0000313|EMBL:EOY05146.1, ECO:0000313|Proteomes:UP000026915};
RN [1] {ECO:0000313|EMBL:EOY05146.1, ECO:0000313|Proteomes:UP000026915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Matina 1-6 {ECO:0000313|Proteomes:UP000026915};
RX PubMed=23731509; DOI=10.1186/gb-2013-14-6-r53;
RA Motamayor J.C., Mockaitis K., Schmutz J., Haiminen N., Iii D.L.,
RA Cornejo O., Findley S.D., Zheng P., Utro F., Royaert S., Saski C.,
RA Jenkins J., Podicheti R., Zhao M., Scheffler B.E., Stack J.C., Feltus F.A.,
RA Mustiga G.M., Amores F., Phillips W., Marelli J.P., May G.D., Shapiro H.,
RA Ma J., Bustamante C.D., Schnell R.J., Main D., Gilbert D., Parida L.,
RA Kuhn D.N.;
RT "The genome sequence of the most widely cultivated cacao type and its use
RT to identify candidate genes regulating pod color.";
RL Genome Biol. 14:R53.1-R53.24(2013).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC {ECO:0000256|ARBA:ARBA00009439}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM001882; EOY05146.1; -; Genomic_DNA.
DR STRING; 3641.A0A061EJW6; -.
DR EnsemblPlants; EOY05146; EOY05146; TCM_020229.
DR Gramene; EOY05146; EOY05146; TCM_020229.
DR eggNOG; KOG0962; Eukaryota.
DR HOGENOM; CLU_006184_0_0_1; -.
DR InParanoid; A0A061EJW6; -.
DR OMA; FSDYYYR; -.
DR Proteomes; UP000026915; Chromosome 4.
DR GO; GO:0000794; C:condensed nuclear chromosome; IBA:GO_Central.
DR GO; GO:0030870; C:Mre11 complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003691; F:double-stranded telomeric DNA binding; IBA:GO_Central.
DR GO; GO:0051880; F:G-quadruplex DNA binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0043047; F:single-stranded telomeric DNA binding; IBA:GO_Central.
DR GO; GO:0070192; P:chromosome organization involved in meiotic cell cycle; IBA:GO_Central.
DR GO; GO:0032508; P:DNA duplex unwinding; IBA:GO_Central.
DR GO; GO:0006302; P:double-strand break repair; IBA:GO_Central.
DR GO; GO:0090304; P:nucleic acid metabolic process; IBA:GO_Central.
DR GO; GO:0000722; P:telomere maintenance via recombination; IBA:GO_Central.
DR GO; GO:0007004; P:telomere maintenance via telomerase; IBA:GO_Central.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR InterPro; IPR004584; Rad50_eukaryotes.
DR InterPro; IPR013134; Zn_hook_RAD50.
DR NCBIfam; TIGR00606; rad50; 1.
DR PANTHER; PTHR18867:SF12; DNA REPAIR PROTEIN RAD50; 1.
DR PANTHER; PTHR18867; RAD50; 1.
DR Pfam; PF13476; AAA_23; 1.
DR Pfam; PF04423; Rad50_zn_hook; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51131; ZN_HOOK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00471}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000026915};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00471}.
FT DOMAIN 648..747
FT /note="Zinc-hook"
FT /evidence="ECO:0000259|PROSITE:PS51131"
FT COILED 228..343
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 545..647
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 808..957
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1038..1092
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 695
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00471"
FT BINDING 698
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00471"
SQ SEQUENCE 1316 AA; 152959 MW; DFDF5C6A44588B06 CRC64;
MSTVDKMLIK GIRSFDPENK NVITFFKPLT LIVGSNGAGK TTIIECLKLS CTGELPPNAR
SGHSFIHDPK VAGETETKGQ IKLRFKTAAG KDVVCIRSFQ LTQKASKMEY KAIESVLQTI
NPHTGEKVCL SYRCADMDRE IPALMGVSKA ILENVIFVHQ DEANWPLQDP STLKKKFDDI
FSATRYTKAL EVIKKLHKDQ AQEVKAYKLK LEHLQTLKDA AYKLRESIAQ DQEKTESLKS
QIQDLEKNID NLDAKIHNAE ATLKDLRKLE DQKSTKTAER STLFKEQQKQ YAALAEENED
TDEELMEWKT KFDERIMLLE NKIQKMESNQ QDLNNESSAY RRKLETYIGE IGKLQRDAEN
LVVLKDERDS AIRGLYVKLN LGSIPNSPFS DEVALNLTNQ IEVRLMELDK DLDEKKKSNE
MKLKSAWDCY MGANDRWNST EAQKKAKLEI KSSILKRLEE KKIDRDSLEL QISDVNLSRI
DEREKNMQIE IDRKKKQLDE RNFDANIRQK QHEVYDIDQK IKVLNRERDI IAGDAEDRTL
LSIKKSELEN KKKQHKKIID EYKDRIRGVL KGRVPTDKDL KREITKALRS LQMEFDELST
KSSEAEKEVN MLQMKIEEIN NNLSKHHKDM DSRKRFLEAR LNSLDQQSFT IDSYPNFLET
AKEKKDIHKS KFNIADGMRQ MFDPFERVAR AHHICPCCER PFSAEEEDEF VKKQRVKAAS
SAEHMKVLAM ESSNAESHFQ QLDNLRMVYE EYVKIGKETI PLAEKTLHKL TEELDQKSQA
HYDVLGVLAQ VKTDKDSIET LVEPIETADR IFQEIQSLQA QVEGLEYKFD FRGQGTRTME
EIQLELNGLQ STRDVLHNEV EKLRDEQIFM EKDLSSIQLR WHDIREKKVE VANTLRDFKK
AEEELEHLAE EKSQLDLEEK HLAEALSSLF KEKERLLKDY ECLKVKLTQE YEQQDKSRSA
YQHEAEALSQ INNKIKGYYN LNKGEKLKEL LEQQSVMESQ LLSCDARKQE ISAELNKSKD
LMRNQDQLRR NIEDNLNYRK TKAEVDKLTR EIDLLQERAL EIGGISKFEG ELRKISEERE
RLLSEINRCR GTMSVYQSNI SKNKAELKQA QYKDIDKRYF DQLIQLKTTE MANKDLDRYY
NALDKALMRF HSMKMEEINK IIRELWQQTY RGQDIDYISI HSDSEGAGTR SYSYKVVMQT
GDAELEMRGR CSAGQKVLAS LIIRLALAET FCLNCGILAL DEPTTNLDGP NAESLAAALL
RIMEDRKGQE NFQLIVITHD ERFAQLIGQR QHAERYYRVT KDDHQHSIIE AQEIFD
//
