ID A0A061ESY8_THECC Unreviewed; 855 AA.
AC A0A061ESY8;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=Minichromosome maintenance 8 {ECO:0000256|ARBA:ARBA00042306};
GN ORFNames=TCM_022086 {ECO:0000313|EMBL:EOY07748.1};
OS Theobroma cacao (Cacao) (Cocoa).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Byttnerioideae; Theobroma.
OX NCBI_TaxID=3641 {ECO:0000313|EMBL:EOY07748.1, ECO:0000313|Proteomes:UP000026915};
RN [1] {ECO:0000313|EMBL:EOY07748.1, ECO:0000313|Proteomes:UP000026915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Matina 1-6 {ECO:0000313|Proteomes:UP000026915};
RX PubMed=23731509; DOI=10.1186/gb-2013-14-6-r53;
RA Motamayor J.C., Mockaitis K., Schmutz J., Haiminen N., Iii D.L.,
RA Cornejo O., Findley S.D., Zheng P., Utro F., Royaert S., Saski C.,
RA Jenkins J., Podicheti R., Zhao M., Scheffler B.E., Stack J.C., Feltus F.A.,
RA Mustiga G.M., Amores F., Phillips W., Marelli J.P., May G.D., Shapiro H.,
RA Ma J., Bustamante C.D., Schnell R.J., Main D., Gilbert D., Parida L.,
RA Kuhn D.N.;
RT "The genome sequence of the most widely cultivated cacao type and its use
RT to identify candidate genes regulating pod color.";
RL Genome Biol. 14:R53.1-R53.24(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM001883; EOY07748.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A061ESY8; -.
DR STRING; 3641.A0A061ESY8; -.
DR EnsemblPlants; EOY07748; EOY07748; TCM_022086.
DR Gramene; EOY07748; EOY07748; TCM_022086.
DR eggNOG; KOG0480; Eukaryota.
DR HOGENOM; CLU_000995_7_2_1; -.
DR InParanoid; A0A061ESY8; -.
DR OMA; THTVDWQ; -.
DR Proteomes; UP000026915; Chromosome 5.
DR GO; GO:0042555; C:MCM complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:EnsemblPlants.
DR GO; GO:0007143; P:female meiotic nuclear division; IEA:EnsemblPlants.
DR GO; GO:0007140; P:male meiotic nuclear division; IEA:EnsemblPlants.
DR GO; GO:0009555; P:pollen development; IEA:EnsemblPlants.
DR CDD; cd17759; MCM8; 1.
DR CDD; cd22247; MCM8_WHD; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF47; DNA HELICASE MCM8; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000026915}.
FT DOMAIN 407..614
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
SQ SEQUENCE 855 AA; 94679 MW; E3C1770700063F18 CRC64;
MVGLNKSVHK LPRQSKCPII KPGKIFFPSR NSPAKKVADK QIKSRRKFDE HSVAKFEITF
TTVEMDGAQG ESANDKYGSI NTSNIGSIVP VYITENEYSK DEEKLIFELI RFFSAPPGQD
LAHQVKDDSS SFCLPLDFQK FRKLCDIEEF YAKLADKPKI ALSCMSAAVH QVLLSSSDFS
LEEGMKINIR LHNYPESVIV LKNLKAAYID KLVSVHGTVV KASTVKPLVI KMNFACEKCT
TEIPRMFPDG KFSPPSTCTL HGCKSRTFKP IRSSAQAIDF QKIRLQELLK FEEHEEGRVP
RTVECELTED LVDLCIPGDV VTVTGIIRVI NNYMDIGGGK SKSRNQGFYY LYIEAVSIKN
SKSQSVPEDL QDSDSNARAT ELVDLFSFSP RDLEFIVKFS EEHGSYVFRQ ILQSICPSIY
GHELVKAGIT LALFGGVRKH SMDRNKVPVR GDIHVIVVGD PGLGKSQLLQ AAAAVSPRGI
YVCGNATTNA GLTVAVVKDT MTSDYAFEAG AMVLADRGLC CIDEFDKMTA EHQALLEAME
QQCVSVAKAG LVASLSARTS VLAAANPVGG HYNRAKTVNE NLKMSAALLS RFDLVFILLD
KPDELQDKRL SEHIMSLHAG YGENSPALKK PRVASQNVEG IGMSAKGSSL VSRLRLGPKK
DADFVPLPGP LLRKYIAYAR TYVSPRMSKP AAEILQKFYL QLRDRSTSGD GTPITARQLE
SLVRLAEARA RVELREEITT QDARDAVEIM KESLYDKYVN EHGFVDFGRS GGMSQQKEAK
RFLSALNKQS ELQQKDCFSI SEIYSLADRI GLRVADIDTL VDNLNSVGYL LKKGPKTYQV
LSSSYSRSQP SRSRC
//
