ID A0A061FX36_THECC Unreviewed; 1146 AA.
AC A0A061FX36;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=TCM_044465 {ECO:0000313|EMBL:EOY19369.1};
OS Theobroma cacao (Cacao) (Cocoa).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Byttnerioideae; Theobroma.
OX NCBI_TaxID=3641 {ECO:0000313|EMBL:EOY19369.1, ECO:0000313|Proteomes:UP000026915};
RN [1] {ECO:0000313|EMBL:EOY19369.1, ECO:0000313|Proteomes:UP000026915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Matina 1-6 {ECO:0000313|Proteomes:UP000026915};
RX PubMed=23731509; DOI=10.1186/gb-2013-14-6-r53;
RA Motamayor J.C., Mockaitis K., Schmutz J., Haiminen N., Iii D.L.,
RA Cornejo O., Findley S.D., Zheng P., Utro F., Royaert S., Saski C.,
RA Jenkins J., Podicheti R., Zhao M., Scheffler B.E., Stack J.C., Feltus F.A.,
RA Mustiga G.M., Amores F., Phillips W., Marelli J.P., May G.D., Shapiro H.,
RA Ma J., Bustamante C.D., Schnell R.J., Main D., Gilbert D., Parida L.,
RA Kuhn D.N.;
RT "The genome sequence of the most widely cultivated cacao type and its use
RT to identify candidate genes regulating pod color.";
RL Genome Biol. 14:R53.1-R53.24(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM001888; EOY19369.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A061FX36; -.
DR STRING; 3641.A0A061FX36; -.
DR EnsemblPlants; EOY19369; EOY19369; TCM_044465.
DR Gramene; EOY19369; EOY19369; TCM_044465.
DR eggNOG; KOG1863; Eukaryota.
DR InParanoid; A0A061FX36; -.
DR OMA; ISCYEIT; -.
DR Proteomes; UP000026915; Chromosome 10.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0031647; P:regulation of protein stability; IBA:GO_Central.
DR CDD; cd00121; MATH; 1.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR024729; USP7_ICP0-binding_dom.
DR InterPro; IPR029346; USP_C.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF644; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7; 1.
DR Pfam; PF00917; MATH; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF14533; USP7_C2; 1.
DR Pfam; PF12436; USP7_ICP0_bdg; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:EOY19369.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000026915};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 49..174
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT DOMAIN 194..518
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT COILED 531..559
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1146 AA; 133826 MW; 25AADF04829A5311 CRC64;
MTLMAPPPLD QEDDEMLVPH NDFVDGPQPM EAAEAASTVD AQAVDDPPSG RFTWTIENFS
RLNTKKLYSD IFFVGGYKWR ILIFPKGNNV DHLSMYLDVA DSATLPYGWS RYAQFSLAVV
NQIHNKYTVR KDTQHQFNSR ESDWGFTSFM PLGELYDPTR GFLVNDTCIV EADVAARRVD
DYWLHDSKKE TGYVGLKNQG ATCYMNSLLQ TLYHIPYFRK AVYHMPTTEN DMPSGSIPLA
LQSLFYKLQY SDTSVATKEL TKSFGWDTYD SFMQHDVQEL NRVLCEKLED KMKGTVVEGT
IQQLFEGHHM NYIECINVDY KSTRKESFYD LQLDVKGCKD VYASFDKYVE VERLEGDNRY
HAEQYGLQDA RKGVLFIDFP PVLQLQLKRF EYDFMRDTMV KINDRYEFPL QLDLDRENGK
YLSPEADRSV RNLYTLHSVL VHSGGVHGGH YYAYIRPTLS DQWFKFDDER VTKEDMKRAL
EEQYGGEEEL PQTNPGFNNT PFKFTKYSNA YMLVYIRESD KDKIICNVDE KDIAEHLRIR
LKKEQEEKEQ KRKEKAEAHL YTVIKVARDE DLVEQIGRDI YFDLVDHEKV RSFRIQKLTP
FNVFKEEVAK EFGVPVQNQR FWLWAKRQNH TYRPNRPLTL QEEAQSVGQL REVSNKANNA
ELKLFLEVEL GQDLRPVPPP ERTKEDILLF FKLYDPFKEE FRYVGRMYVR SAGKPMEILA
RINKMAAFGP DEEIELYEEI KFEPNVMCEH IDKKLTFRTS QLEDGDILCF QKSSEVGSEQ
CRYPDVPSFL EYVHNRQVVR FRSLEKPKED EFTLELSKLH NYDDVVERVA QHLGLDDPSK
IRLTSHNCYS QQPKPQPIKY RGVEHLLDML VHYNQTSDIL YYEVLDIPLP ELQGLKTLKV
AFHHATKDEV VIHTIRLPKQ STVGDVLDDL KTKVELSHPN AELRLLEVFY HKIYKIFPLS
DKIENINDQY WTLRAEEIPE EEKNLGPHDR LIHVYHFMKD TAQNQQVQNF GEPFFLVIHE
DETLAEVKVR IQKKLQVPDE EFTKWRFAFL SLGRPEYLQD SDVVSTRFQR RDVYGAWEQY
LGLEHSDNAP KRSYTANQMP KEHEAPVNVV TVSGAPSCVI SSSSSAQLVC VPSYLVKGKS
MIYSLP
//
