ID A0A061H1B2_9BASI Unreviewed; 381 AA.
AC A0A061H1B2;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=TFIIS N-terminal domain-containing protein {ECO:0000259|PROSITE:PS51319};
GN ORFNames=PFL1_06496 {ECO:0000313|EMBL:EPQ26043.1};
OS Pseudozyma flocculosa PF-1.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Pseudozyma.
OX NCBI_TaxID=1277687 {ECO:0000313|EMBL:EPQ26043.1, ECO:0000313|Proteomes:UP000053664};
RN [1] {ECO:0000313|EMBL:EPQ26043.1, ECO:0000313|Proteomes:UP000053664}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF-1 {ECO:0000313|EMBL:EPQ26043.1,
RC ECO:0000313|Proteomes:UP000053664};
RX PubMed=23800965; DOI=10.1105/tpc.113.113969;
RA Lefebvre F., Joly D.L., Labbe C., Teichmann B., Linning R., Belzile F.,
RA Bakkeren G., Belanger R.R.;
RT "The transition from a phytopathogenic smut ancestor to an anamorphic
RT biocontrol agent deciphered by comparative whole-genome analysis.";
RL Plant Cell 25:1946-1959(2013).
CC -!- FUNCTION: Transcription factor involved in RNA polymerase II
CC transcription regulation. May function in both SPT15/TBP post-
CC recruitment and recruitment steps of transcription.
CC {ECO:0000256|ARBA:ARBA00037349}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00649}.
CC -!- SIMILARITY: Belongs to the IWS1 family.
CC {ECO:0000256|ARBA:ARBA00037992}.
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DR EMBL; KE361648; EPQ26043.1; -; Genomic_DNA.
DR RefSeq; XP_007882228.1; XM_007884037.1.
DR AlphaFoldDB; A0A061H1B2; -.
DR GeneID; 19320572; -.
DR KEGG; pfp:PFL1_06496; -.
DR eggNOG; KOG1793; Eukaryota.
DR HOGENOM; CLU_045275_2_1_1; -.
DR OrthoDB; 12240at2759; -.
DR Proteomes; UP000053664; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR46010; PROTEIN IWS1 HOMOLOG; 1.
DR PANTHER; PTHR46010:SF1; PROTEIN IWS1 HOMOLOG; 1.
DR Pfam; PF08711; Med26; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649}; Reference proteome {ECO:0000313|Proteomes:UP000053664}.
FT DOMAIN 219..296
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT REGION 1..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 381 AA; 42669 MW; 9888F51AB172A03C CRC64;
MADEEDQQAT HEQIFGRDSD DEGPDEPPAL TESNADELQT HIEVPTDGAP TTEDPFGEED
EALPSFQRTE RDEAGGDDDE AASSMPRKKK KKKRHHSPDA PPRRSGDDAD GISGDEGEGV
EMSAQDIRRS RTDALIDEAL KSGKRKAPRK RAGEDDLDLL ADEEVSALRR EMVMAADDDE
EANRLKKPAV AKLRLLPRVV QTLQKTHLQQ SILDNNLLEG VKRWLEPLPD KSLPALNIQN
QFFQILEKMS IDTISLKMSG LGKVVVFYSM CPRVEPRIKR IAEHLIEVWS RPVLKRSASY
RDRHVAAAEW HPEMSNSQGL TSTQIIDNGR RNVSIPQAVT SGFRVAPQST AGQKSDSSHE
ARLANHQRLN RFKSRLKEAK R
//
