ID A0A061IUP0_TRYRA Unreviewed; 420 AA.
AC A0A061IUP0;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Tyrosine aminotransferase {ECO:0000256|ARBA:ARBA00015959};
DE EC=2.6.1.5 {ECO:0000256|ARBA:ARBA00012749};
DE AltName: Full=L-tyrosine:2-oxoglutarate aminotransferase {ECO:0000256|ARBA:ARBA00031696};
GN ORFNames=TRSC58_02148 {ECO:0000313|EMBL:ESL10123.1}, TRSC58_06538
GN {ECO:0000313|EMBL:ESL05800.1};
OS Trypanosoma rangeli SC58.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX NCBI_TaxID=429131 {ECO:0000313|EMBL:ESL05800.1, ECO:0000313|Proteomes:UP000031737};
RN [1] {ECO:0000313|EMBL:ESL05800.1, ECO:0000313|Proteomes:UP000031737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC58 {ECO:0000313|EMBL:ESL05800.1,
RC ECO:0000313|Proteomes:UP000031737};
RA Stoco P.H., Wagner G., Gerber A., Zaha A., Thompson C., Bartholomeu D.C.,
RA Luckemeyer D.D., Bahia D., Loreto E., Prestes E.B., Lima F.M.,
RA Rodrigues-Luiz G., Vallejo G.A., Filho J.F., Monteiro K.M., Tyler K.M.,
RA de Almeida L.G., Ortiz M.F., Siervo M.A., de Moraes M.H., Cunha O.L.,
RA Mendonca-Neto R., Silva R., Teixeira S.M., Murta S.M., Sincero T.C.,
RA Mendes T.A., Urmenyi T.P., Silva V.G., da Rocha W.D., Andersson B.,
RA Romanha A.J., Steindel M., de Vasconcelos A.T., Grisard E.C.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L-
CC glutamate; Xref=Rhea:RHEA:15093, ChEBI:CHEBI:16810,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:36242, ChEBI:CHEBI:58315; EC=2.6.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001125};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRNR:PIRNR000517, ECO:0000256|PIRSR:PIRSR000517-1};
CC -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC acetoacetate and fumarate from L-phenylalanine: step 2/6.
CC {ECO:0000256|ARBA:ARBA00005203}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
CC aminotransferase family. {ECO:0000256|ARBA:ARBA00007441,
CC ECO:0000256|PIRNR:PIRNR000517}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESL05800.1}.
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DR EMBL; AUPL01006538; ESL05800.1; -; Genomic_DNA.
DR EMBL; AUPL01002148; ESL10123.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A061IUP0; -.
DR EnsemblProtists; ESL05800; ESL05800; TRSC58_06538.
DR EnsemblProtists; ESL10123; ESL10123; TRSC58_02148.
DR VEuPathDB; TriTrypDB:TRSC58_02148; -.
DR VEuPathDB; TriTrypDB:TRSC58_06538; -.
DR OrthoDB; 5474881at2759; -.
DR UniPathway; UPA00139; UER00338.
DR Proteomes; UP000031737; Unassembled WGS sequence.
DR GO; GO:0004838; F:L-tyrosine:2-oxoglutarate aminotransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR CDD; cd00609; AAT_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR004838; NHTrfase_class1_PyrdxlP-BS.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR005958; TyrNic_aminoTrfase.
DR InterPro; IPR005957; Tyrosine_aminoTrfase.
DR NCBIfam; TIGR01264; tyr_amTase_E; 1.
DR NCBIfam; TIGR01265; tyr_nico_aTase; 1.
DR PANTHER; PTHR45744; TYROSINE AMINOTRANSFERASE; 1.
DR PANTHER; PTHR45744:SF2; TYROSINE AMINOTRANSFERASE; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR PIRSF; PIRSF000517; Tyr_transaminase; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00105; AA_TRANSFER_CLASS_1; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:ESL05800.1};
KW Phenylalanine catabolism {ECO:0000256|ARBA:ARBA00023232};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRNR:PIRNR000517};
KW Reference proteome {ECO:0000313|Proteomes:UP000031737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ESL05800.1};
KW Tyrosine catabolism {ECO:0000256|ARBA:ARBA00022878}.
FT DOMAIN 39..410
FT /note="Aminotransferase class I/classII"
FT /evidence="ECO:0000259|Pfam:PF00155"
FT MOD_RES 258
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR000517-1"
SQ SEQUENCE 420 AA; 46493 MW; 6A3FFE4811177F3B CRC64;
MPTQKMGSWD VSMSNHAGLV VNPIRSISDN AKPSPSPKPI IKLSVGDPTL DKNLLTPASH
MEKLKKVVDS QDWNGYLPTV GAPEACDAIA TWWRNSFVHN KQLKGSIVKD NVVCCSGGSH
GILMAITAIC DAGDYVLVPK PGFPHYETVC KAYGLGMHLY NCRADKNWEA DLDEIRRLKD
DKTKLIVITN PSNPCGSNFR RQHVEDLVRL AEELRLPMFA DEIYAGMVFK GKDPNATFTS
VADFDSTVPR VILGGTAKNL VVPGWRLGWL IYVDPHGTGR GFLDGLKRVA MLVCGPNTLA
QGAVSEALLN TPQEYLDGIV SKIEESAMYL YEHLAECVGV VPTMPQGSMY VFSKIELEKF
KDIKTDVEFF EKLLEEENVQ VLPGSIFNLP GFMRVTTTRP VSVYREAVER MKAFCKRHAA
//
