ID A0A061IUX9_TRYRA Unreviewed; 2434 AA.
AC A0A061IUX9;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Serine/threonine-protein kinase TOR {ECO:0000256|RuleBase:RU364109};
DE EC=2.7.11.1 {ECO:0000256|RuleBase:RU364109};
GN ORFNames=TRSC58_06676 {ECO:0000313|EMBL:ESL05666.1};
OS Trypanosoma rangeli SC58.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX NCBI_TaxID=429131 {ECO:0000313|EMBL:ESL05666.1, ECO:0000313|Proteomes:UP000031737};
RN [1] {ECO:0000313|EMBL:ESL05666.1, ECO:0000313|Proteomes:UP000031737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC58 {ECO:0000313|EMBL:ESL05666.1,
RC ECO:0000313|Proteomes:UP000031737};
RA Stoco P.H., Wagner G., Gerber A., Zaha A., Thompson C., Bartholomeu D.C.,
RA Luckemeyer D.D., Bahia D., Loreto E., Prestes E.B., Lima F.M.,
RA Rodrigues-Luiz G., Vallejo G.A., Filho J.F., Monteiro K.M., Tyler K.M.,
RA de Almeida L.G., Ortiz M.F., Siervo M.A., de Moraes M.H., Cunha O.L.,
RA Mendonca-Neto R., Silva R., Teixeira S.M., Murta S.M., Sincero T.C.,
RA Mendes T.A., Urmenyi T.P., Silva V.G., da Rocha W.D., Andersson B.,
RA Romanha A.J., Steindel M., de Vasconcelos A.T., Grisard E.C.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775,
CC ECO:0000256|RuleBase:RU364109};
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031, ECO:0000256|RuleBase:RU364109}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESL05666.1}.
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DR EMBL; AUPL01006676; ESL05666.1; -; Genomic_DNA.
DR EnsemblProtists; ESL05666; ESL05666; TRSC58_06676.
DR VEuPathDB; TriTrypDB:TRSC58_06676; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000031737; Unassembled WGS sequence.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:InterPro.
DR GO; GO:0010507; P:negative regulation of autophagy; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0051128; P:regulation of cellular component organization; IEA:UniProt.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd05169; PIKKc_TOR; 1.
DR Gene3D; 1.20.120.150; FKBP12-rapamycin binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR009076; FRB_dom.
DR InterPro; IPR036738; FRB_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR024585; mTOR_dom.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR026683; TOR_cat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF126; SERINE_THREONINE-PROTEIN KINASE TOR; 1.
DR Pfam; PF11865; DUF3385; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF08771; FRB_dom; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01346; DUF3385; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01345; Rapamycin_bind; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47212; FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU364109};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU364109};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364109};
KW Reference proteome {ECO:0000313|Proteomes:UP000031737};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU364109};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU364109}.
FT DOMAIN 1287..1859
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2034..2354
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2402..2434
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2434 AA; 273696 MW; EBDB5B66A1AC762C CRC64;
MFTIAGKDNL ASTIRRIADD PARRTAVVEE EIKRTKELQR KNLQEYESTV SSLLICLENF
DVVRGDAPEI TCALTVLDIL LRLDLTTIQI SQCSSYARLC LCAVSDTSIA PAAARTFAET
LVNSMTSDFA RMEIDETLSW IELPDDSMRA RRICGLLVLQ QVALRIPMLI LPKLGTLCEK
LWSGLASSDG MIRDTSAQLF KVCGKLLSNR SPTLRIKTVD TLLSQLKSNL AAKSRESNLA
GLLAFETVVM SSIGGSSQPR YEDLSIMLVP YIMSGGSSAN SELVQKLLFH CLVVLCRYNT
TLFIINHLKD TVSFALKSIR NLFQHCTAFD MLSDIIPMVG KSAFTSFVKE TCEAVCFISE
MSPTPCWESL KCFSVIFREC PPPDVESYID PCIENVFNWG LSSQLIECMR DIISLSSIKG
RTKLEEALLD MISVTLCGLP FRQVAGTRIK TGNYPDSEPT ESQIVVALDA LIQFGFSDSE
LMGDFLRDSV LPLIDSPSAC VRNAAVNTIV SLLIPPGIKG ELTMARRICV DMIVSRMLVV
GLANPDPVIR ATILSSFTQS FYPYLSELQF LTQLFSALGD EDICCRIAAT GLLCRMVNHY
PSHILPILRK EILHILYTLS SEDTGNKVLN GLLLLDAVAS NAPQFVVNLT DGIIKVLGRH
LSALEVNSPI LQPLLRCCTS VARAVRFFGH NKPIFTLEVE RVCELLDLLP LDTEFAASRL
WCLRFIGATL GPQIGGRSPY DVYPQLYRRL SGILKNSDDD LDLRLEALRC AGTIGVLDTR
VFQSLGLGQN TQQTKLERNN SHTLSHAMCC RHVLRAIASL LDPDEKRVSV SKDSLLRVGI
QTVLYIGECC PCSRAEMAVV IPAIVRAAGE LSPGRLLGIV LHELAQIVKC VGPTSLSNVA
TLHTFCDVAW ERCPVYRFLI VRLASTIASL REKGDQKYLQ SDARVLPIKL DALNDADSSE
YLRYAILEYV VKHTETLQFC AEIVVLDLLR ATQRNPIEFG VYAVTALRTV CTTLNVDELT
GVIVRGLLAA LKMHSTILMQ NTEYTSFTNR IMSVFCVLIV QLQGEFIKYS SQVIRTLKTL
RISNAEFTTL QGLLLKGFPC TLSASLLAEY HTQVVSLLKK CELMVTRGIS YLGEVWSARN
NTEDAAVVFS DDERPLPLAE QRIINTLKTT PLTKEEWLRW IDQFSISVMQ ESPYRVFRCV
SLPIGTNSTP LVERSPEFTQ DILRLAFRAL WNFGSASIRS SIVDFFRQTL QRPTWSSTVP
DDFITAMLSL VEYMDVVGMT LPIAANDLSE CAWSRGMLAK ALYWREVAYR EDPASTIESL
TILYSELHQP DSAVSLLGGA SESQKRYLLQ QSEILRLAGY TEALRLTQQE IDRDMMGSET
SSESFVKPLQ YRSKNLRRFC GVTGRSYPDI SAFFRSEDTT SDLQMEQQVR QMMSLSEFGD
YDKVLQQWGV IFNQYKGKKV DTEENILFYV SQYAADASIR LQSWGTLEDA LMWMPKDSVH
YYISRAALSI HKGQYDEASL AVNEGRKLLL DELAGLLHES YIRAYESLVI AQELSELEEV
VVAQRVKEAV STQHLCSISR LWSQRILMMS PTVPVWKQVL SVRGLLIPPS EDVTTQLRFV
KLCRRANAKQ LERFTLLQLL GSRCPTYEQL MSHNANPRVV MQYIGFLSEN GELGPNGPYG
LESDLLRKLI DTHSKVENAT LLSRAYVRLG TKAELREAIE CYKAATLYDP NWFHAWRMCA
EANVELLNTN YSDAAYAAAI EGYIQSIKLG ISDSTMIQDV LKLLTLLSRP SDSEDGLRKL
REQVLEVSSR AWYLVVPQLI ARLDSGSDGS CQLIADILTP VAFDYPISLL YPLNLSAMSD
SERRKKLAHM ILEKLKAKFP VIVLQGRLVI HELLRISDLV YEKWYDQLDA AANAFFGRRH
YHEMVENLLL LHEELHRAPE TIVEAEFTCK YSKSLQEAQE WLQSYKRTGS VADLHSAWHI
YHCVYRQIDE HVRARNRLQL PFCSPKLFEA RNLSVGIPDA MPTDEGSVSC IASFNDTLVV
IASKQRPKRL SVITTEGKKQ KYLLKGREDL RLDERVMQLF RLVNSLMMSD SRACKNSGFQ
IKRYSVTPLK DTVGIIGWVS GCDTLHELVK KYRTYRGVPA ELELRMLNQI ITFDQPRAYD
FLTVMSKVEV MEFLADHTTG HDIRKVMWIS AASCETWLEQ RQEFTTSLAT TSVVGYILGL
GDRHPNNIMI QRTSGLMVHI DFGDCFEVAM TRDKFPEKVP FRLTRMLRNA LDVSGVDGAF
RTRAEIAMCV LRDGSHSVLA ILEAFIQDPL ISWRLLNRPG EEPQSSAERH TFEQMRPRKL
YSPAAFRGKP PRDSVSTEAV RTARHASVRE EVDMTHKGVT IFGRVRSKLK GEDFMQTALA
SASMDPKAQV ARLIVEATDI TNVAQSWSGW YPFW
//
