ID A0A061J8D9_TRYRA Unreviewed; 411 AA.
AC A0A061J8D9;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
GN ORFNames=TRSC58_01701 {ECO:0000313|EMBL:ESL10565.1};
OS Trypanosoma rangeli SC58.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX NCBI_TaxID=429131 {ECO:0000313|EMBL:ESL10565.1, ECO:0000313|Proteomes:UP000031737};
RN [1] {ECO:0000313|EMBL:ESL10565.1, ECO:0000313|Proteomes:UP000031737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC58 {ECO:0000313|EMBL:ESL10565.1,
RC ECO:0000313|Proteomes:UP000031737};
RA Stoco P.H., Wagner G., Gerber A., Zaha A., Thompson C., Bartholomeu D.C.,
RA Luckemeyer D.D., Bahia D., Loreto E., Prestes E.B., Lima F.M.,
RA Rodrigues-Luiz G., Vallejo G.A., Filho J.F., Monteiro K.M., Tyler K.M.,
RA de Almeida L.G., Ortiz M.F., Siervo M.A., de Moraes M.H., Cunha O.L.,
RA Mendonca-Neto R., Silva R., Teixeira S.M., Murta S.M., Sincero T.C.,
RA Mendes T.A., Urmenyi T.P., Silva V.G., da Rocha W.D., Andersson B.,
RA Romanha A.J., Steindel M., de Vasconcelos A.T., Grisard E.C.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESL10565.1}.
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DR EMBL; AUPL01001701; ESL10565.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A061J8D9; -.
DR EnsemblProtists; ESL10565; ESL10565; TRSC58_01701.
DR VEuPathDB; TriTrypDB:TRSC58_01701; -.
DR OrthoDB; 66776at2759; -.
DR Proteomes; UP000031737; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR028081; Leu-bd.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR Pfam; PF13458; Peripla_BP_6; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
PE 3: Inferred from homology;
KW Receptor {ECO:0000313|EMBL:ESL10565.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 28..322
FT /note="Leucine-binding protein"
FT /evidence="ECO:0000259|Pfam:PF13458"
SQ SEQUENCE 411 AA; 44438 MW; F09C20D6E72CC3B9 CRC64;
MPRCGRHNSA AAGDVCVEVV RREAKMSEFV AVLEGAVQKE NGTLALLGQF GDTYLKAALP
VLPRFDLVAF APFTASSAVR GWNPNVYFVR PDPVAELLAL IRHAVTELRV LRVGFMYLRG
VFFGDGECEQ AGRVMSEMGY ELSGVFTVDS DAGGGADPKE FDAAWERFAA ARPQAVIVFG
SPVRDTKKFV RRMLTDGRTA GAYLLAPSVV QSVVVRTWRA VVAAGGAEFV PGQVISTGTT
PLAKDTQYGA IRRFQGVMRD YLANGGQTDY NDTEHFLKND SDGELMVDGW VAGEVLAQAL
SNRKWVSDRK AFMASLFNQR RYVVDDLVIG DYGGECKGAA ASRGATCRCN GGGRTVYMKR
FVEGYRAEAV GEGLMTFRLS DCNVSSTLVP PVFSGVALLM ADGGAAHRCV W
//
