ID A0A061JD35_TRYRA Unreviewed; 1038 AA.
AC A0A061JD35;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Ubiquitin-like 1-activating enzyme E1A {ECO:0000256|ARBA:ARBA00044354};
GN ORFNames=TRSC58_00202 {ECO:0000313|EMBL:ESL12036.1};
OS Trypanosoma rangeli SC58.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX NCBI_TaxID=429131 {ECO:0000313|EMBL:ESL12036.1, ECO:0000313|Proteomes:UP000031737};
RN [1] {ECO:0000313|EMBL:ESL12036.1, ECO:0000313|Proteomes:UP000031737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC58 {ECO:0000313|EMBL:ESL12036.1,
RC ECO:0000313|Proteomes:UP000031737};
RA Stoco P.H., Wagner G., Gerber A., Zaha A., Thompson C., Bartholomeu D.C.,
RA Luckemeyer D.D., Bahia D., Loreto E., Prestes E.B., Lima F.M.,
RA Rodrigues-Luiz G., Vallejo G.A., Filho J.F., Monteiro K.M., Tyler K.M.,
RA de Almeida L.G., Ortiz M.F., Siervo M.A., de Moraes M.H., Cunha O.L.,
RA Mendonca-Neto R., Silva R., Teixeira S.M., Murta S.M., Sincero T.C.,
RA Mendes T.A., Urmenyi T.P., Silva V.G., da Rocha W.D., Andersson B.,
RA Romanha A.J., Steindel M., de Vasconcelos A.T., Grisard E.C.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein sumoylation.
CC {ECO:0000256|ARBA:ARBA00004718}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family.
CC {ECO:0000256|ARBA:ARBA00005673, ECO:0000256|RuleBase:RU000519}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESL12036.1}.
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DR EMBL; AUPL01000202; ESL12036.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A061JD35; -.
DR EnsemblProtists; ESL12036; ESL12036; TRSC58_00202.
DR VEuPathDB; TriTrypDB:TRSC58_00202; -.
DR OrthoDB; 20494at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000031737; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 2.40.30.180; Ubiquitin-activating enzyme E1, FCCH domain; 1.
DR Gene3D; 3.50.50.80; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1; 1.
DR Gene3D; 3.40.50.12550; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2; 1.
DR Gene3D; 1.10.10.2660; Ubiquitin-activating enzyme E1, SCCH domain; 1.
DR InterPro; IPR042302; E1_FCCH_sf.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR018965; Ub-activating_enz_E1_C.
DR InterPro; IPR042449; Ub-E1_IAD_1.
DR InterPro; IPR019572; UBA_E1_SCCH.
DR InterPro; IPR042063; Ubi_acti_E1_SCCH.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR InterPro; IPR018075; UBQ-activ_enz_E1.
DR InterPro; IPR033127; UBQ-activ_enz_E1_Cys_AS.
DR InterPro; IPR000011; UBQ/SUMO-activ_enz_E1-like.
DR NCBIfam; TIGR01408; Ube1; 1.
DR PANTHER; PTHR10953:SF162; SUMO-ACTIVATING ENZYME SUBUNIT 1; 1.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR Pfam; PF09358; E1_UFD; 1.
DR Pfam; PF00899; ThiF; 2.
DR Pfam; PF10585; UBA_E1_SCCH; 1.
DR PRINTS; PR01849; UBIQUITINACT.
DR SMART; SM00985; UBA_e1_C; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS00865; UBIQUITIN_ACTIVAT_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU000519};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU000519};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU000519};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000031737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|RuleBase:RU000519}.
FT DOMAIN 904..1031
FT /note="Ubiquitin-activating enzyme E1 C-terminal"
FT /evidence="ECO:0000259|SMART:SM00985"
FT ACT_SITE 598
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10132"
SQ SEQUENCE 1038 AA; 114541 MW; 29C0AC80214C294D CRC64;
MTHEDEKRQL YNRQEYVVGV ETQAKYGSTD VLVVGVCGLG AELVKNLVLT GVRSVQIMDG
GAATLQDLGT NFFLTPQDIG KPRADVVAIR AQELNRFVSV TAVTRPLHEV IPTVHVVVFA
NQRTTALVGE NAFARRHDVK FVACESRGVV GCVFVDAGPS FSVLDPDGEE TVSCIVTSIS
HDGVVSLHED KNHECEVGSH IFFTGVLSPA ALNANIDQSN IHGRSQSAAA SSLKLFEVAE
VISPYILRLK NFEAEVGNES IKVGTAAYLH TTKRHVLMGF KDLEQSVADP AFVDIFDSEQ
KLNAPATLHA VFRALHDHGT LPSNPAEVNA VLNAAEVYYN SCSSGCLDVA AARSVLSVIH
GNLNPMTCFI GGLASQEVLK VCSGKFTPIQ QWLYYDAREL LVARGEVTEA DLRPSSPTGS
RYDQQIAVLG AEFQSYLSRQ RAFIVGAGAL GCELIKNAAC MGLGGISITD MDDIEMSNLS
RQFLFRNSHI GQHKSKVAGE AARAINHDLQ VTSFVEKVSP ETEGIFNEKF WDSHALVLNA
LDNVESRKYV DSRCLFYKKA LFESGTLGTK CNVQCIIPYC TESYSSSHDP PEKSIPLCTL
KNFPNAIEHT IQWARDNFQV LFTSTAEEVN AYLQDPAAFA TELERDPATR TLALKAVRDA
LVRWPNDAAD CVRIARALYH EYFNDAFRQL LYNIPVDKRN ENGEMFWSGA KKPPTPQEFS
PDSELNMSFV YHCAYLLACV YGLPQFTLSR EEVMQMAQET AVPEFVPRQA IFATSEAEKE
ESVAHLVTDV RLQDLPPVGK FHGRRMIPLQ FEKDDPTNHH VEYITACSNM RAVAYNIPPA
SVHHTKRIAG NIIPAMVTTT ALVTGLVGLE VLKRLLLSKR REKSGMPANA PPAHNEIQEQ
LSIYRNAFVN IALPFIAFSD PIMAPGASYV MPDGQPVRWG IWDRIDVNEG RDLTVQELVA
VLESRYQVEL FIIALASGKM IYSQFGNTKD RGKPVSVVVQ ERGEQLQDGE DHCCLIATGS
MGDVDVDIPV IRYRFRNF
//
