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Database: UniProt
Entry: A0A063YJV4_9MOLU
LinkDB: A0A063YJV4_9MOLU
Original site: A0A063YJV4_9MOLU 
ID   A0A063YJV4_9MOLU        Unreviewed;       466 AA.
AC   A0A063YJV4;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   25-OCT-2017, entry version 26.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
GN   ORFNames=NPL2_02425 {ECO:0000313|EMBL:KDE44567.1}, NPL3_02005
GN   {ECO:0000313|EMBL:KDE42132.1}, NPL4_00985
GN   {ECO:0000313|EMBL:KDE45583.1}, NPL5_00490
GN   {ECO:0000313|EMBL:KDE44015.1}, NPL6_02765
GN   {ECO:0000313|EMBL:KDE43936.1}, NPL7_00700
GN   {ECO:0000313|EMBL:KDE42261.1};
OS   Mycoplasma hyosynoviae.
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=29559 {ECO:0000313|EMBL:KDE44567.1, ECO:0000313|Proteomes:UP000027286};
RN   [1] {ECO:0000313|Proteomes:UP000027004, ECO:0000313|Proteomes:UP000027005, ECO:0000313|Proteomes:UP000027116}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NPL2 {ECO:0000313|EMBL:KDE44567.1,
RC   ECO:0000313|Proteomes:UP000027286}, NPL3 {ECO:0000313|EMBL:KDE42132.1,
RC   ECO:0000313|Proteomes:UP000027004}, NPL4 {ECO:0000313|EMBL:KDE45583.1,
RC   ECO:0000313|Proteomes:UP000027116}, NPL5 {ECO:0000313|EMBL:KDE44015.1,
RC   ECO:0000313|Proteomes:UP000027294}, NPL6 {ECO:0000313|EMBL:KDE43936.1,
RC   ECO:0000313|Proteomes:UP000027005}, and NPL7
RC   {ECO:0000313|EMBL:KDE42261.1, ECO:0000313|Proteomes:UP000027173};
RA   Kittichotirat W., Bumgarner R.E., Lawrence P.;
RT   "Comparative genomics of Mycoplasma hyosynoviae isolated from infected
RT   pig joint fluid.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577,
CC       ECO:0000256|SAAS:SAAS00747914}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KDE44567.1}.
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DR   EMBL; JFKJ01000029; KDE42132.1; -; Genomic_DNA.
DR   EMBL; JFKG01000007; KDE42261.1; -; Genomic_DNA.
DR   EMBL; JFKH01000034; KDE43936.1; -; Genomic_DNA.
DR   EMBL; JFKM01000003; KDE44015.1; -; Genomic_DNA.
DR   EMBL; JFKK01000042; KDE44567.1; -; Genomic_DNA.
DR   EMBL; JFKI01000009; KDE45583.1; -; Genomic_DNA.
DR   RefSeq; WP_036443795.1; NZ_JFKM01000003.1.
DR   EnsemblBacteria; KDE42132; KDE42132; NPL3_02005.
DR   EnsemblBacteria; KDE42261; KDE42261; NPL7_00700.
DR   EnsemblBacteria; KDE43936; KDE43936; NPL6_02765.
DR   EnsemblBacteria; KDE44015; KDE44015; NPL5_00490.
DR   EnsemblBacteria; KDE44567; KDE44567; NPL2_02425.
DR   EnsemblBacteria; KDE45583; KDE45583; NPL4_00985.
DR   Proteomes; UP000027004; Unassembled WGS sequence.
DR   Proteomes; UP000027005; Unassembled WGS sequence.
DR   Proteomes; UP000027116; Unassembled WGS sequence.
DR   Proteomes; UP000027173; Unassembled WGS sequence.
DR   Proteomes; UP000027286; Unassembled WGS sequence.
DR   Proteomes; UP000027294; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000027004,
KW   ECO:0000313|Proteomes:UP000027005, ECO:0000313|Proteomes:UP000027116,
KW   ECO:0000313|Proteomes:UP000027173};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000027005}.
FT   DOMAIN      157    290       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      372    441       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   466 AA;  54274 MW;  578FA876AF503D99 CRC64;
     MNNNQSENSD KQLTIKTNNL TFKNELKNNL SDDFAFEHLF SNVQIVYEEP EIIYLLVPHQ
     IKDLLKNSYF SSIERAIHNV YSKKMNIILI TDIEELNALH ALDLQNEENA SKNQKETVKN
     IKTNIRENLK FENYAIGKFN SFTIRAAKNI CESQKVEISP FFVHSDSGLG KTHLLHAMGN
     EYLKQGKTCL YINPDDLTRK LVEQLRNKNQ DEINKIVDEI IAYDCVMFDD IQQYAHKENT
     LNVLFNILNH LINNNKQIII AADKSPSELG GFEQRFITRF SGGIIVNINT LELEDVIEIL
     KFKLRENDIN PEYWENESLK FIARNFSTSI RSLEGAINRI KLFKQDDDFF TYDIATIKSI
     FQYVSQIKET ITPDKIIEVV SKYYKIDKKK ITSKTRKEEV VMARRIAMWI IKNYFDYSLE
     QIGKMFGAQS HSTVIVSVQW VDNNRKTNPT LKLALEKIDE NLNKIL
//
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