ID A0A066XMT8_COLSU Unreviewed; 4028 AA.
AC A0A066XMT8;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Putative beta-ketoacyl synthase domain-containing protein {ECO:0000313|EMBL:KDN70187.1};
GN ORFNames=CSUB01_07850 {ECO:0000313|EMBL:KDN70187.1};
OS Colletotrichum sublineola (Sorghum anthracnose fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum graminicola species complex.
OX NCBI_TaxID=1173701 {ECO:0000313|EMBL:KDN70187.1, ECO:0000313|Proteomes:UP000027238};
RN [1] {ECO:0000313|Proteomes:UP000027238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TX430BB {ECO:0000313|Proteomes:UP000027238};
RX PubMed=24926053; DOI=10.1128/genomeA.00540-14;
RA Baroncelli R., Sanz-Martin J.M., Rech G.E., Sukno S.A., Thon M.R.;
RT "Draft genome sequence of Colletotrichum sublineola, a destructive pathogen
RT of cultivated sorghum.";
RL Genome Announc. 2:E0054014-E0054014(2014).
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC family. {ECO:0000256|ARBA:ARBA00029443}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KDN70187.1}.
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DR EMBL; JMSE01000380; KDN70187.1; -; Genomic_DNA.
DR STRING; 1173701.A0A066XMT8; -.
DR eggNOG; KOG1178; Eukaryota.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_37_2_1; -.
DR OMA; HRERITH; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000027238; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19532; C_PKS-NRPS; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF20; HYBRID PKS-NRPS SYNTHETASE APDA; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000027238};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..439
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 170..282
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2398..2480
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3534..3611
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2492..2529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4028 AA; 440484 MW; 42F0E5E98C909797 CRC64;
MASRNEPIAI IGSACRFAGG VDSPAKLWEL LSNPRDVRTE IPSSRFSADG FYHVDSQYHG
HSNVRHAYVL EQDPGVFDAQ FFGVKPVEAK ALDPQQRLLL EVVYEGLEAA GIPAEDLRGS
NTGVYVGLMS NDYESLMLRD VDTMANYHAV GTQRSILANR ISYFYDWHGP SMVVDTACSS
SLVALHLAVQ ALRTGEARTA LACGSNLLLG PENFVGYSKM KMLSPDGKSM TWDRDANGYA
RGEGVATVVL KTLRAALEDG DHIECIIRET GTNQDGATPG ITMPSAESQR ALIRDTYRRA
SLDPRDPADR CQYFEAHGTG TQAGDPIEAE AIYRSFFDDD SGDADSLYVG SLKSIIGHTE
GTAGIASILK ASLALQNKQI PPNLWFNNVN PKILPFCKNL RVPTINPKEW AEPLNSQPRR
TSVNSFGFGG ANAHAILEEF QGPQAADVPS DLERNAQCFT PCVFSAHSEK SLLANLAAYL
DFLDKHPSVG LRDLAGTLRQ RRSALPVSVA FSVSSIQELK SAISAKVQQQ QEDEVGRRLL
AGSPGTREAK RGILGVFTGQ GAQYARMGAE LVEKSAYADK LLQVLEGHLA DLPVQDRPGW
SLKAELLADA ATSRLGEAAI SQPLCTAVQI LLVDLLRLAN VRFSGVVGHS SGEIGAAYAA
GYLSARDAMC IAYYRGLHSS PPPGSKGAML AVEASFEEAQ ELCGRADLPG KISVAASNSS
SSVTLSGDED AIAFIEQALG EQGTFRRRLR VDRAYHSHHM LPCSGPYLKA LGSCNIQVQE
PSRDCTWFTS TRSFESSSEL KGVYWADNMT QPVLFSQAVA AAASSGGFDL ALEVGPHPAL
KGPATQTVLE VSGHQIPYHG TLSRSADAVR ATSDALGFLW SLLGKAEVDL DTYESKVSGL
TSFDVLKGLP GYRWDHDKTF WHESQVSRNM RLRRLPVHPL LGHLSPTSSP HHLSWRNVLR
LKELPSLAGH ELQGQVVFPA AGYLSSALEA ASFLSDGRSI RLIQIRDFDI YHPIVLDSDD
VEVVISLTEV DKAGPDTLRS TFTYSSSGLG KDSGTLTLVA KGKVEVSFGE PSMSILPPDG
GPTPNMIPVD RERFYESLSE LGYNYSGPFR ALSSLNRSLG RASGSIGNEG LRAEDKDETP
LMAQPGILDS AIQSILLAHS YPGDGHLWSL QVPTSIRQLR MNPSLCGSAW RGSNGLSFRS
TADDLTGSGG LRGDVSIYVQ GSAHAAMQLE GVKIVPLAAA TAADDIRMFS RTVWGPGHPD
AAEAADGDMA MADELEFASV LERISSFYLR KIDENVPTDH PAREAGPLAG YLNFARHVND
LVKSGEHPYT KKEWLNDTLD HIKAASLRFA DTPDVKILHT IGEQMPHVIE GKTTILEHAR
PNGLLDDYYV NALGLPQVSR WLANTVAQVT HRYSDMNILE VGAGTGGATK SILGRIGRDF
SSYTFTDVST GFFENAASTF ERHGDRMIFK KLDAEQDPIE QGFVANSYDL VVASFVIHAT
SKLRETMTHL RRLLKPGGFV ILAEITDNEQ IRTPFIFGTL PGWWVGVDEG RTLSPCVSPE
SWDSILTDAG FSGIDTITPD SFKAVHPFSV FVSQAIDDRL TFLRSPLSSP PTSAVPRVPI
EHLFVVGGNT LREKRLVTEL GKILRPYSRA VTVFKTLADV NHSLVTPEST LLSLVDLEKP
VFKNITKAEF DSLKNLFGTE KTLLWVTQGR REKDPFANMS VGFGRTAVCE VPELRLQFLD
VESDRVDARA VAEAVLRLQL GSFWAQQEVQ NDQLWSLEPE VVIDDAGRLL VPRLEPSAVL
NSRYNSARRS VVRNASLQEE AVRVCKIGDK FVLQEDVPQA PDTKPAVESP LVQLRATHTL
VSAIKTPLGH YFLSIGVDPD TQSRYFVLTD SPSSTIRVPL SAAVPVPASA HHDDGQLLVL
LGDAIISLTV LDGVFPGQMV LVHNATPELH NALSRQAAEK GVNIVFTTSS TSSALPTSWT
RLHPYMTAAE IKTILPHGNV DAFVGFSGPD LSSQQLESSV IDTLSPKSRV ETTGTIFSSS
SSPLPSSDLA PAIGEILRKG VSSASAIDSA ASLEGVSTVA IADLAAGKEP AENMTVLVWP
LSSSSSPSSV PVGVSRLDSR MLFKSDKTYW LAGLTGTLGL SLCKWMVEHG AKHVVITSRS
PKVDPTCDIS SYDDVKSLYE HIRTTLPPLA GVAQGAMVLR DTSIRNMTFD QMTDVLRPKV
DGSINLDSVL GEHPLDFFVF FSSILEITGN MGQANYTAAN AFMSTLAAQR RKRGLAASVI
NIGVITGVGF VTREASTVQE KALHRSGLML LSEKDMHQIF AEGIEASRLD SSPSGQQLQI
TAGLRSIPID SADLPTWRSD PKFSRFIVQE TDTGAGEANV AARASSMSSL KQQLQGTKSS
AEAEHILVEA LGRKIRSVLQ TDTPDDALMR MSTDEIGLDS LIAVDIRSWL LKHFELEVPV
LKLLGGMRLT DLVAKSVQGL LGAVSDSTSQ SEVDEMSASI HSSGDTSSQQ ASSTSDDLPE
PTLTSTSLAG SELFTKPEAV AERSLAISFS QSLFWVVDSL VEDKTAPNHT VLMRVVGQPR
LSVLRNAVEM VGRRHEALRT RFRMDGEQHT VQEVLESPTL ELEEVRVSDE ADVMLEYDSL
KRHVYDLGSG RLMRIILLSR SPSDNWLLVG FHHINVDGMS FQVVMQDLDK LCRGQQLNPK
TMQYPDFSEA QRTALSSGAW VEDIEYWKRE FATIPEPLPL TRARITTRRP ITRFSVHTKE
LRVDGALSGR IREVARANKV TSFHFYLTAF QILLHRFTGA EDMAIGVADS GRNDQGEVLD
SVGPFLNLIP LRFEVTPAQT FGRLIADTRR KSYAGLAHSR VHFEVLLTEL QVPRVATQSP
IFQAFVDYRQ GAQERQPLAN CTLEMMELQM GSTGYDLSLD VIDNPEGDAR IALMGQAHLY
SVSDMDIIGG LFEDILNEFV QSPAKRISEG WQYRQADVER ALQVGQGQIR KSEWPETLIG
QFEVSAEKHK RNTALIHADG TSLTYAQMQQ RIDTIAAALE ENSIKPGDSV GVFQESTTDW
VCSMMALWKR GAVFVPLDPG TKTERLAMVV KDCKPAAILI DDATKGLHTE LGATERTVFI
NVSALTTKTD APSSKILASP DDLAMVYYTS GSTGNPKGIA VRHEGVRDVF ESACWLYGVN
EKVVTLLQSS LGFDITLIQM FISWPVGGTV CMISRDMRGD SVALMEFMTK HNVTHTVGTP
SEYNSWLRFG DQAKLRSSAW RVAICGAEAF PPTLLEKLRE LNKPDLQLFH MYGTTETTVY
ATQQELNWKQ EGFYDDGVMP AGFSLPNKSM YIVDEDMHLL PVGLPGEIVL GGVGVAQGYN
NNELMTKASF VPNTFAPNGS PFHRKGWTTM YRTRDRGRLL PDGSIVVEGR IGGDTEIKLR
GLRIDLKDIE HAILRSADGV LSEAVASVRS TAGTDTQFLV AHVVFSPANA PKDRQSFLSD
LLDNLPLPRY MCPSVLVPIE KMPMSMSSKL DRRAVATLPV NRPDRLTAER GASQALNEAE
IRLKEVWEQV IPQGMFDIAR DSDFFHVGGT SLLLVELQAR IRQRFDCTLR LADLFANSML
CTMSKLIPQQ ESVATVAADG DDDGNGNEMP SMEIDWEWET RPAPELQIGT ADLSVVVPPS
PNPKSVIITG GAGFLGRSLL KSAIENPHIE RVHAVAVRKL QQRLASGLLP QHPKVTYYDG
DLREPLIGLS QEDADAIFND IDAVIHNGAD VSHLKSYFTL RRANLNATKE LARLCLPRRI
PFHYVSTAGV SMFTFWQSFG EETASAAEPP TDGTNGYKAS KWASERFLER LNEKLGLPVW
MHRPSDMVRQ DDEEASWDLL HTLLGYSRKL RAVPVSENLW GWLDLVAVYN VSHDIVQMVH
DNRPRSTDGR VSYVHQTGDM AIPIDEMKEF FEEECGYTHV FEKLPIKEWA RRAELAGMRP
AVAAVFGNVP RLPRALCFPR FVKTWRPSEG QDGGMLLMKK CDCGGLVSPV WGEGCEGCGK
SPVMPVWG
//
