ID   A0A067BQ30_SAPPC        Unreviewed;       660 AA.
AC   A0A067BQ30;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=Arf-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=SPRG_17723 {ECO:0000313|EMBL:KDO16772.1};
OS   Saprolegnia parasitica (strain CBS 223.65).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Saprolegnia.
OX   NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO16772.1, ECO:0000313|Proteomes:UP000030745};
RN   [1] {ECO:0000313|EMBL:KDO16772.1, ECO:0000313|Proteomes:UP000030745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO16772.1,
RC   ECO:0000313|Proteomes:UP000030745};
RX   PubMed=23785293;
RA   Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA   van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA   Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA   Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA   Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA   Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA   Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA   Russ C., Tyler B.M., van West P.;
RT   "Distinctive expansion of potential virulence genes in the genome of the
RT   oomycete fish pathogen Saprolegnia parasitica.";
RL   PLoS Genet. 9:E1003272-E1003272(2013).
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DR   EMBL; KK583936; KDO16772.1; -; Genomic_DNA.
DR   RefSeq; XP_012212521.1; XM_012357131.1.
DR   AlphaFoldDB; A0A067BQ30; -.
DR   EnsemblProtists; KDO16772; KDO16772; SPRG_17723.
DR   GeneID; 24139253; -.
DR   KEGG; spar:SPRG_17723; -.
DR   VEuPathDB; FungiDB:SPRG_17723; -.
DR   OMA; HIADFAF; -.
DR   OrthoDB; 1079051at2759; -.
DR   Proteomes; UP000030745; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   CDD; cd08204; ArfGap; 1.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   PANTHER; PTHR12296:SF21; DENN DOMAIN-CONTAINING PROTEIN 3; 1.
DR   PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF03456; uDENN; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00800; uDENN; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN          6..133
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   DOMAIN          173..660
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
SQ   SEQUENCE   660 AA;  71999 MW;  019AB46355F472FB CRC64;
     MSKNGQRVAD LVRGSPENMA CADCGVALTT ASDATWAAIT FGAFVCLQCA GAHRQLGVNI
     SRVKSVHMDN WTDDEVKKML GNRAVNAVYE KHLRPDAKAA TRRALQANAM SRDDYVRLKY
     ETRTFTTEAG KTFEGPSSDK SEKRTTTSGS IVEVSKRFVN YFVVVGRGQA VLGKPLGENA
     GPSDVQFVPT ILDSFPDAHA DAPLPSHISQ FAFPEGLALS QTHITPTFFT FVLTNVSGAK
     LYACALKFVE ELSPLEVLTL FAPPPGNEKT KAPIIPKWAQ DLSAGSASTT SVYSPKCLLL
     ISHHPFFSGY RLFLQQIYRL SLSTAPMPIE RYIANFVCEV PMPPRGRIQV QLTLPERTIY
     VARPPKNQLP LADFSLRSLF QVLDMNNVLT VVSCLLLEQK VALCSKHLAL LTPIAETLLT
     LLFPLAWQGA YIPVLPSSLL DVIDAPVPFL VGVHSKYLAT ASRSTDVFFI DLDHNRVIPP
     RNEDGIETVL PKMPERAATK LKVKLQNCAN VFDPFAPDIA KADWAFGGDE CLEPITDFAS
     SGMTLPMPSD VVSSRRGSLG DKRTLSAASA ASLAASSSLS SSLHFSSFKL LSHTSSSASM
     LERDRSLSSS SSVDSLMLPT PALGGGFVQD QVRQSFLRFF ISMLKRYAFY LQQDQHGAHL
//