ID   A0A067BS52_SAPPC        Unreviewed;       669 AA.
AC   A0A067BS52;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Polycystin cation channel PKD1/PKD2 domain-containing protein {ECO:0000259|Pfam:PF08016};
GN   ORFNames=SPRG_15667 {ECO:0000313|EMBL:KDO17502.1};
OS   Saprolegnia parasitica (strain CBS 223.65).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Saprolegnia.
OX   NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO17502.1, ECO:0000313|Proteomes:UP000030745};
RN   [1] {ECO:0000313|EMBL:KDO17502.1, ECO:0000313|Proteomes:UP000030745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO17502.1,
RC   ECO:0000313|Proteomes:UP000030745};
RX   PubMed=23785293;
RA   Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA   van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA   Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA   Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA   Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA   Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA   Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA   Russ C., Tyler B.M., van West P.;
RT   "Distinctive expansion of potential virulence genes in the genome of the
RT   oomycete fish pathogen Saprolegnia parasitica.";
RL   PLoS Genet. 9:E1003272-E1003272(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; KK583644; KDO17502.1; -; Genomic_DNA.
DR   RefSeq; XP_012211790.1; XM_012356400.1.
DR   AlphaFoldDB; A0A067BS52; -.
DR   EnsemblProtists; KDO17502; KDO17502; SPRG_15667.
DR   GeneID; 24137375; -.
DR   KEGG; spar:SPRG_15667; -.
DR   VEuPathDB; FungiDB:SPRG_15667; -.
DR   OMA; AHEDIVH; -.
DR   OrthoDB; 49832at2759; -.
DR   Proteomes; UP000030745; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR013122; PKD1_2_channel.
DR   PANTHER; PTHR10877:SF183; AT14535P-RELATED; 1.
DR   PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR   Pfam; PF08016; PKD_channel; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        55..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        325..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        406..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        449..468
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        474..493
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        505..529
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          406..533
FT                   /note="Polycystin cation channel PKD1/PKD2"
FT                   /evidence="ECO:0000259|Pfam:PF08016"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   669 AA;  75093 MW;  2F1C8270FB0737D2 CRC64;
     MKHPSDEQTL PSPFDNWSPD IESIPRLSEG DRTETISTTD ARAALTTRAE LRTHFLNVPF
     PIVLFFAFVS VVLTHTPIYQ VFFVNHGISI ALSPLPADTV HRPGTLEFMN IRTAADFESW
     FEFTMLPEIF PAKGANNSAL ENATIGRIGS YNQVVGAVEV SVLNAPKAKC PSDGRLASHY
     GGCYDFESDF DITDGDLHTR NTRRQPWYTL YLPLQEPSPY TKYRVWQEHG SIGGYYINLG
     TRQIDIKITT YNGELDMFTY LRFALEFQAG GAIEPKYSVN SVPANPYAES HINLLPDVLV
     ALLAIRLVVR RFVQLASRMK ARTAWVTGVD VIEWLSVASL VVYYIAWVRL FQRCFASDFE
     DQVAALRTFY DSVYALPVAD QSEAMASSPQ PSVSDFMNGF APALSFLYMM SILTCLQLAV
     NVMSALHFHP TMSILSTTIM ASVRRLGTFL FLFLLVVVAL ATSGALLFGP KLEAFASLGA
     AMVTCINMIF NGYEYDHIKD IHPLAVVWYW LSQSIITLVL VNIMLAVIIS AHEDIVHVDH
     GKRSFLQEML WVLRDILHTD CVCKGRHGLR LQERLAIDNG TRVWTAAEIA QAIGISDAQG
     ARWVRTLKQF ASVHTTASAD ATEDAATPSM DEMAYRRRLE DRIKFIDAKL EGLVEYMQLH
     EQQRMLQHV
//