ID   A0A067BU28_SAPPC        Unreviewed;      1231 AA.
AC   A0A067BU28;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN   ORFNames=SPRG_13486 {ECO:0000313|EMBL:KDO20340.1};
OS   Saprolegnia parasitica (strain CBS 223.65).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Saprolegnia.
OX   NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO20340.1, ECO:0000313|Proteomes:UP000030745};
RN   [1] {ECO:0000313|EMBL:KDO20340.1, ECO:0000313|Proteomes:UP000030745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO20340.1,
RC   ECO:0000313|Proteomes:UP000030745};
RX   PubMed=23785293;
RA   Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA   van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA   Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA   Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA   Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA   Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA   Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA   Russ C., Tyler B.M., van West P.;
RT   "Distinctive expansion of potential virulence genes in the genome of the
RT   oomycete fish pathogen Saprolegnia parasitica.";
RL   PLoS Genet. 9:E1003272-E1003272(2013).
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DR   EMBL; KK583315; KDO20340.1; -; Genomic_DNA.
DR   RefSeq; XP_012208938.1; XM_012353548.1.
DR   AlphaFoldDB; A0A067BU28; -.
DR   STRING; 695850.A0A067BU28; -.
DR   EnsemblProtists; KDO20340; KDO20340; SPRG_13486.
DR   GeneID; 24135361; -.
DR   KEGG; spar:SPRG_13486; -.
DR   VEuPathDB; FungiDB:SPRG_13486; -.
DR   OMA; QWHERIV; -.
DR   OrthoDB; 68370at2759; -.
DR   Proteomes; UP000030745; Unassembled WGS sequence.
DR   CDD; cd00821; PH; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR025875; Leu-rich_rpt_4.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR45973:SF23; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7; 1.
DR   PANTHER; PTHR45973; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED; 1.
DR   Pfam; PF12799; LRR_4; 1.
DR   Pfam; PF14580; LRR_9; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00365; LRR_SD22; 10.
DR   SMART; SM00369; LRR_TYP; 5.
DR   SMART; SM00233; PH; 4.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 3.
DR   PROSITE; PS51450; LRR; 7.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
PE   4: Predicted;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          141..240
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          252..348
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          569..588
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          605..648
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          788..808
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1231 AA;  137695 MW;  AC9C787224690BD9 CRC64;
     MRDDFYSGFL LRGHAPRAKS TKDINAQYTD PSLLEMLGIK LPAPSAPELR MAPMRLFFVL
     TPTRMDYYLV DPRPKFKLPI SGSFAFNRST EVAVCSEMWP GLPPHTFCVT TDGQTLVLTA
     KTHGDMSTWL THLQATLAHF PFVLRSSLLK KSDKYPWKPW TKRHVELGES CVSYANATPG
     AQFVRNHVRL TAHAYVQDLP PTKAHAFVFG IATAHTTLTF AAASDQEKQE WMTELEIRIL
     RHKVLQHQHK KASEFAGYVD VRCASTKGWR RLYCTLHNGV VVLKTNEKRM GVKTKIYLEM
     VLKVEPSTPT ARANAFTIQR FGAPDLYVAA FSATEKNTWL RHLATARSEA KDAPSVAFER
     DIQALVKTTG YVHVTVYAHE RLELLLEQWH ERIVTCNALD HVPRGSVLVR LKDASGKHHA
     FDVMWHALRT KARPVKLTFR VPIAKDGILR VHTSTPVSQW VPRRCRVADG TWTVDALTQV
     DATPLIAWPL RACSVNLVHD YNATSLEDDV PNCFYIEYTP LPPTRELVAG AATTAVPSTT
     LHVSAASASD CVLWLAILRL EIAIARGDPT LTPAAPTRTE RRRQSLVDQT KKVAELLYGV
     DHRPKVPEMA STESLPPPPP IEPEVDTTWR DRSGSDNDDD DDDDGPSLTE KLAHALVTVP
     VQYMVETKAT MAQLVSTTIA AKKLQLLATQ EVQDLVAFSQ KVQVRVAPLA KSVRQQSRRV
     SRSCVRQLVE LKGALRVPNP TTNPRFDSTK RYLQASVRGQ SAQSIEASTR KKTDRFVAAQ
     VVIEQWAKRT SSDTPSQTNT ENGESASLSM ETARRFFDHV ASYDDKEKIP YLQLLDLLRL
     LCGRAMTPTS AVDAFEAEID RLESVHEITY SLTKLRFLQI ATETIRDPAL VDTVECALAV
     APPAARVARV VEETIPKPVE TQDASENKEL PLTECVEFRP DDEEIYHVGT AGLKARVLDG
     LEAMVQLREL HVRSNLLYKM TGIESLVNLT HLELYDNQIK KMVGLEKLVK LRVLDLSFNE
     IRSIPDLSHL TQLEELYVAN NKLTHITGIG NLRTLVKLDL GANRIRTIEG LDHLENLEQL
     WLGKNKITAI QGLGALTKLR VMSIQSNRLL AIDNLSANVA LEELYLSHNG IEALANLDHL
     TKLTILDVGA NRIKTIPHMG ANVALEDLWL NDNEISSFDD IQHLAANVKL ETLYLERNPL
     ASDFEYRLKI QGALASVQQI DATPVVRRQQ G
//