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Database: UniProt
Entry: A0A067C454_SAPPC
LinkDB: A0A067C454_SAPPC
Original site: A0A067C454_SAPPC 
ID   A0A067C454_SAPPC        Unreviewed;       367 AA.
AC   A0A067C454;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   25-OCT-2017, entry version 16.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=SPRG_22235 {ECO:0000313|EMBL:KDO25283.1};
OS   Saprolegnia parasitica (strain CBS 223.65).
OC   Eukaryota; Stramenopiles; Oomycetes; Saprolegniales; Saprolegniaceae;
OC   Saprolegnia.
OX   NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO25283.1, ECO:0000313|Proteomes:UP000030745};
RN   [1] {ECO:0000313|EMBL:KDO25283.1, ECO:0000313|Proteomes:UP000030745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO25283.1};
RX   PubMed=23785293;
RA   Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L.,
RA   Christie J., van den Ackerveken G., Bottin A., Bulone V.,
RA   Diaz-Moreno S.M., Dumas B., Fan L., Gaulin E., Govers F.,
RA   Grenville-Briggs L.J., Horner N.R., Levin J.Z., Mammella M.,
RA   Meijer H.J., Morris P., Nusbaum C., Oome S., Phillips A.J.,
RA   van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J., Seidl M.F.,
RA   Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA   Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q.,
RA   Dieguez-Uribeondo J., Russ C., Tyler B.M., van West P.;
RT   "Distinctive expansion of potential virulence genes in the genome of
RT   the oomycete fish pathogen Saprolegnia parasitica.";
RL   PLoS Genet. 9:E1003272-E1003272(2013).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KK583233; KDO25283.1; -; Genomic_DNA.
DR   RefSeq; XP_012204028.1; XM_012348638.1.
DR   EnsemblProtists; KDO25283; KDO25283; SPRG_22235.
DR   GeneID; 24142618; -.
DR   KEGG; spar:SPRG_22235; -.
DR   EuPathDB; FungiDB:SPRG_22235; -.
DR   KO; K02154; -.
DR   OMA; AWETINE; -.
DR   Proteomes; UP000030745; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 2.
DR   Pfam; PF01496; V_ATPase_I; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030745};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    303    327       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       98    125       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   367 AA;  41704 MW;  C44C8EFB21FE4123 CRC64;
     MEYVSLIIHE DAAHDCITML GDLGVVEFTD LNPELTPFQR RYASYIQRCN EMDRKLRCFM
     VEMTKFKISA KSADNVDSFL AGSPDVCHSS QDTTVRALNS IERILEDKEQ ELLQLNSMHE
     KLTREYNERK ELQEIISRIG GLVETELSDA MRVSSRMGSS ITTSVDSPMD ASESDLAIRF
     KNITGVVPAD ERLNFERMVF RATRGNCFMR FSAIDELLAD PGTGVAVEKH AFVIFFQSQF
     IETKLRKICD AFHARIDTIE FVLNMVSNTA SYLRLWALSL AHSELSTVFF EKAMLSTINM
     DSFVAIFIGF AIFAGTTFGV ILCMDVLECF LHALRLHWVE FQGKFYKADG IAFNPLRLKD
     LRSSMDS
//
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