ID A0A067C7N5_SAPPC Unreviewed; 801 AA.
AC A0A067C7N5;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=GPI ethanolamine phosphate transferase 2 {ECO:0000256|ARBA:ARBA00020830};
GN ORFNames=SPRG_07930 {ECO:0000313|EMBL:KDO26528.1};
OS Saprolegnia parasitica (strain CBS 223.65).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO26528.1, ECO:0000313|Proteomes:UP000030745};
RN [1] {ECO:0000313|EMBL:KDO26528.1, ECO:0000313|Proteomes:UP000030745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO26528.1,
RC ECO:0000313|Proteomes:UP000030745};
RX PubMed=23785293;
RA Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA Russ C., Tyler B.M., van West P.;
RT "Distinctive expansion of potential virulence genes in the genome of the
RT oomycete fish pathogen Saprolegnia parasitica.";
RL PLoS Genet. 9:E1003272-E1003272(2013).
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
CC {ECO:0000256|ARBA:ARBA00005315}.
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DR EMBL; KK583223; KDO26528.1; -; Genomic_DNA.
DR RefSeq; XP_012202671.1; XM_012347281.1.
DR AlphaFoldDB; A0A067C7N5; -.
DR STRING; 695850.A0A067C7N5; -.
DR EnsemblProtists; KDO26528; KDO26528; SPRG_07930.
DR GeneID; 24130179; -.
DR KEGG; spar:SPRG_07930; -.
DR VEuPathDB; FungiDB:SPRG_07930; -.
DR OMA; RVKFGHD; -.
DR OrthoDB; 5479199at2759; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000030745; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd16024; GPI_EPT_2; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037674; PIG-G_N.
DR InterPro; IPR039527; PIGG/GPI7.
DR InterPro; IPR045687; PIGG/GPI7_C.
DR PANTHER; PTHR23072:SF0; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2; 1.
DR PANTHER; PTHR23072; PHOSPHATIDYLINOSITOL GLYCAN-RELATED; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR Pfam; PF19316; PIGO_PIGG; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 734..755
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 615..760
FT /note="GPI ethanolamine phosphate transferase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19316"
SQ SEQUENCE 801 AA; 86915 MW; DA9E57456C18C067 CRC64;
MVRRLIRNLM LVWSTARVGA ICGAAVLAAF LGASGLFGLD LDVFHAPLSK AAPPSSVPPA
MPPVFDRLVF VVVDALRADM VLGSAAVQHA HATEELRSYM PYTAQLASSP ESIPYIGHAA
VPTVTMPRLK ALTTGKKPAF IDVLRNFNSK ALEEDSLLAQ LAAAGRRMVL YGDETWLQLF
PTAFLRSDPT SGFFALDTVE VDTNVTRHLH EELDPTMTSP KSSDWDALFL HYLGVDHIGH
LTGPHSPLMR AKLSEMDATI ESIHVSIRAQ DVARNGSTLL VLLSDHGMTE TGNHGGASIE
ESSALLLFVL PPSHRAVHHS DRLTRTPQVD LVPTLATLLG VPIPVHNTGK VLTSVLDAAV
RDDARVIAAL QANVHQLRAL AAPKHSAKFW ASFAHDFGFA LDWHVASTSI PLALARRRME
AALSSLQAIV LTSDGSEYTT EHMLCGILVG LLGLVLACRL DVLLLRRPSR YELCLGFWTL
LQLISLGSSS SIENEHVVWN VLLVSYLMWL AIDVFLTKRR RGVWLAWLLV PLTARLLRSR
NQIINFGRLN GFDVAAGVNR DGLEYEHDNA VSILTTRSLV YGIISLPAER VLASAYVLLA
ELARSTSSPV ALKAAWTIGM VATVVFSMTA VDAAAHTVYA SVVVEAGAAL WHRTSPMKAL
WLLAFLLQRD TNLMALALLH VQLDAATCLV QALDVLRALP LVVYLSKASF FALGNSHLMT
TIDISKAYTG LSSYSQVLVG GLTAYIVFTG PLLVLSSQLA AVRNVRSLIA GYWTLELGSF
TVYRYARPVS RPAISIYSGV L
//
