ID A0A067C7Q1_SAPPC Unreviewed; 1670 AA.
AC A0A067C7Q1;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Myosin motor domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=SPRG_08074 {ECO:0000313|EMBL:KDO26784.1};
OS Saprolegnia parasitica (strain CBS 223.65).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO26784.1, ECO:0000313|Proteomes:UP000030745};
RN [1] {ECO:0000313|EMBL:KDO26784.1, ECO:0000313|Proteomes:UP000030745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO26784.1,
RC ECO:0000313|Proteomes:UP000030745};
RX PubMed=23785293;
RA Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA Russ C., Tyler B.M., van West P.;
RT "Distinctive expansion of potential virulence genes in the genome of the
RT oomycete fish pathogen Saprolegnia parasitica.";
RL PLoS Genet. 9:E1003272-E1003272(2013).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; KK583221; KDO26784.1; -; Genomic_DNA.
DR RefSeq; XP_012202432.1; XM_012347042.1.
DR EnsemblProtists; KDO26784; KDO26784; SPRG_08074.
DR GeneID; 24130311; -.
DR KEGG; spar:SPRG_08074; -.
DR VEuPathDB; FungiDB:SPRG_08074; -.
DR OMA; MKQIRDN; -.
DR OrthoDB; 90944at2759; -.
DR Proteomes; UP000030745; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140:SF856; HEAVY CHAIN, UNCONVENTIONAL MYOSIN; 1.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF00784; MyTH4; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Reference proteome {ECO:0000313|Proteomes:UP000030745}.
FT DOMAIN 109..863
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1438..1588
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT REGION 229..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1557..1587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 204..211
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1670 AA; 183266 MW; 4AABEB1005D2560C CRC64;
MEERFRVDSS ASSESAEQTM YMERPEQWVW CPDDALVCVP GVIVAQGAEA NTLIVHTEDG
EERQLDIDEA LPVCMDLSLR VSDVAELFLQ RPETPPDHAD AISARLLGNL TGRNETQAQA
LEHALLYTLR TRYRDEQIYT ECGASVLLSM NPKRPVPLYT PDRIRAYRHR QTLHELPPHL
FGLAEDAMRA LHESGDDQAI VLLGESGSGK SEAAKLVLQY LCHHEQSRGS IRTKSRSNAS
EGSASASSSS SSISVHIPVE EQILHAVAVL EAFGHVQLAS NANASRVVKL TSVDYDSHGR
LLAGSVSTYG LEKARVVQTK ERNFHIFHYL LAEASVNPTL SDILDLQDTV LAATSPFTFA
AGDIRPSDAI KYQDVVSSLA ALRVPSHHVQ NMMKVLAVIL HLGNVVFVPS TPHDTSENAS
CVVLESSSPS LIRAASLLEV EASVLDHYFR TRKMVTSNHQ SSLKIVSVSQ AARARDTFCR
NLYEALFNAV VFRMNASLRS KVERYEKSNI MVENRGIHVL DGFGFEMVAD PSSSSSSSSS
PSSLIDDTML LVHVQGLETL HAHYWAEKAR SFYLSRVFES PASTSPLDPT KYVRLYEGTP
AGIYVVLNEH MASKAKQAHD AHFVNKLLVA NENIGNPSLQ PVLPSSTNKK NYKLQFLVHH
SAGSIIYEAD DMARRNNKSV SSTAAAILKS SRNSFVKGLV DRYGNSPTHA AAASASAGHV
RIAVNFNAIK ANQPDTNSVA TDLMQQATAL FDGLSSMGQH FVVCVNPAQS AAIEVDARYV
LRQLRSFQVL ALMHASQRNL SVQMTPPHFF ARYRHLCGHR NTLESLVRSL TAIGVLEDLT
WRIDNNQVWL TLHQRKKLEK VREVCLNANA TMLQRNLQRG VYRKLCLRRR SGLLSLRDAM
AARDRHGIQQ SLAFAKTWVE ATAQVRILVA ATAMLHQIEE ESYLVSLLED ALRMDVKIVL
QFALHTVATL SPSWKPEMLK TAHARLRHKT AMDNAMTALR QAMLSSTADP SRLMALLSEQ
EGRGSDERQL ATMVMIRALE TKKVKDAVLP AKGSSATAAE WNQCIARAIE FGLGDDLLDM
MAASWDAWAC LREQGSRGDV TAVEAVLEKA VAKESVTTID ACMGILKEAG CPPSPLLDAA
AQLLEKVILK PSLERSQAIE LIDFAIEAGH LKLLAAALKR CKAVGMASWD ANVKRATQAH
AALATTASAP NDDDAWRRLV AKDFDGVRAS PDSPAHAIVS ALDARAAAIA ALHDLPAETQ
LERAAQLGVL PQFASVAKDF FQRLDAARNV EALLHWTTFL AFRLDHGHEV RQDMLTLLAS
QTQLVTSLGA NNAHAALDAA ASITKRLQRA LTNRSKLEKL LKAPVNARAL AKGIDEASDA
GVDAALLSAA HDVLRKLSVA AADETIDETP SSSIVDASHG IAPLEMALYP GLRVRRDENP
PPFVWEYRVL DQPVLSGVPA HHSVYIHRCI LGYMRDRVMS FREMLAQSIL QVGLAHQYLV
DEIFAQLVKQ LSNNPRRESV RRGWDLLGLC LTCFRPSSSL HPYLVAFLSK DNVSSTTSRR
RLETTTTDSD DDHDVDDEPS EVHDNETPLD QRLALLKARG VAQYCLARLE GDSAAEGFLP
SLGELQAFEL RSPFVASIEL LDGTLLTTNF PVSPELSVMN VVQVCAHFCT
//
