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Database: UniProt
Entry: A0A067C8B3_SAPPC
LinkDB: A0A067C8B3_SAPPC
Original site: A0A067C8B3_SAPPC 
ID   A0A067C8B3_SAPPC        Unreviewed;       864 AA.
AC   A0A067C8B3;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   07-JUN-2017, entry version 16.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=SPRG_12198 {ECO:0000313|EMBL:KDO22771.1};
OS   Saprolegnia parasitica (strain CBS 223.65).
OC   Eukaryota; Stramenopiles; Oomycetes; Saprolegniales; Saprolegniaceae;
OC   Saprolegnia.
OX   NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO22771.1, ECO:0000313|Proteomes:UP000030745};
RN   [1] {ECO:0000313|EMBL:KDO22771.1, ECO:0000313|Proteomes:UP000030745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO22771.1};
RX   PubMed=23785293;
RA   Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L.,
RA   Christie J., van den Ackerveken G., Bottin A., Bulone V.,
RA   Diaz-Moreno S.M., Dumas B., Fan L., Gaulin E., Govers F.,
RA   Grenville-Briggs L.J., Horner N.R., Levin J.Z., Mammella M.,
RA   Meijer H.J., Morris P., Nusbaum C., Oome S., Phillips A.J.,
RA   van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J., Seidl M.F.,
RA   Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA   Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q.,
RA   Dieguez-Uribeondo J., Russ C., Tyler B.M., van West P.;
RT   "Distinctive expansion of potential virulence genes in the genome of
RT   the oomycete fish pathogen Saprolegnia parasitica.";
RL   PLoS Genet. 9:E1003272-E1003272(2013).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KK583263; KDO22771.1; -; Genomic_DNA.
DR   RefSeq; XP_012206555.1; XM_012351165.1.
DR   EnsemblProtists; KDO22771; KDO22771; SPRG_12198.
DR   GeneID; 24134179; -.
DR   KEGG; spar:SPRG_12198; -.
DR   EuPathDB; FungiDB:SPRG_12198; -.
DR   KO; K02154; -.
DR   OMA; WTAYDAH; -.
DR   Proteomes; UP000030745; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030745};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    419    443       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    463    481       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    560    581       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    593    613       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    672    691       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    795    815       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       99    133       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   864 AA;  97824 MW;  3389ABD89ADD6CDE CRC64;
     MKWLRSEEME YISLIVNEDA AHDCVQKLGD LGVVEFTDLN PELTPFQRRY VSYVKRCDEM
     DRKLRFFAGE MAKLKITAKS AGSVDSFLAG SADVRYGSQD TAVRALDTLE RILEDKEQEL
     LQLNSMHEKL TREYNERKEL QEIISRVGEF FEIELPDATR RDTSSRVSSR TGSSMNFGVG
     SPMDASESDL AIRFKNITGV VPADERLKFE RMVFRATRGN CFTRFSAIDE LLVDPGTGVA
     VEKHAFTKLR KICDAFHARL YTLPSMDDRT AIANLIQNNN AELNQSSHIL RRNRESCVLL
     CRELAEHHES WKWSVLQEKA TYHTLNTFKA DVSGMLRGEG WVVKEALDQV RRAVDRAHNA
     DDKSMPSLVD SVPKPWPVAP THFQTNKFTS ALQSFVDTYG VPRYGEINPA VFTAVSFPFL
     FGVMYGDIGH GFCIFLFGLY MIATEKILER GKVGEMTAQI YGGRYMITLM GVFAMYAGFV
     YNDFFSLPLN LFGSKWQYLD NCEELGLKHE KCEAYYHYDG VPNGTVDVAN GHNVYGFGLD
     PIWKTSENEL LFFNSFKMKL SVILGITQMG FGILIKGWNA LYFKDYPTFF FDFLPQLVFA
     ASLFFYMVVL IVMKWSIDWT ERMSHEVCPF NFEGPATGCR PPALINTLIN IALQPGAVAD
     PMYEGQKKMQ QTLLAFAGLS VPIMLLCHPL YMKFKYGSPA QEVSHQVDFD NLSDDDDHAK
     LAPAAHGGHG HGHGDEPFNF GEAAIHQGIE TIEFVLGMVS NTASYLRLWA LSLAHSELAT
     VFFEKAMLST INMDSFVAIF IGFALFAGTT FGVILCMDVL ECFLHALRLH WVEFQNKFYK
     ADGNKFHPFN FKEMIRATQF EASN
//
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