ID   A0A067CC78_SAPPC        Unreviewed;       827 AA.
AC   A0A067CC78;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=Ras-GEF domain-containing protein {ECO:0000259|PROSITE:PS50009};
GN   ORFNames=SPRG_06603 {ECO:0000313|EMBL:KDO28364.1};
OS   Saprolegnia parasitica (strain CBS 223.65).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Saprolegnia.
OX   NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO28364.1, ECO:0000313|Proteomes:UP000030745};
RN   [1] {ECO:0000313|EMBL:KDO28364.1, ECO:0000313|Proteomes:UP000030745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO28364.1,
RC   ECO:0000313|Proteomes:UP000030745};
RX   PubMed=23785293;
RA   Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA   van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA   Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA   Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA   Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA   Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA   Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA   Russ C., Tyler B.M., van West P.;
RT   "Distinctive expansion of potential virulence genes in the genome of the
RT   oomycete fish pathogen Saprolegnia parasitica.";
RL   PLoS Genet. 9:E1003272-E1003272(2013).
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DR   EMBL; KK583211; KDO28364.1; -; Genomic_DNA.
DR   RefSeq; XP_012200812.1; XM_012345422.1.
DR   AlphaFoldDB; A0A067CC78; -.
DR   STRING; 695850.A0A067CC78; -.
DR   EnsemblProtists; KDO28364; KDO28364; SPRG_06603.
DR   GeneID; 24128943; -.
DR   KEGG; spar:SPRG_06603; -.
DR   VEuPathDB; FungiDB:SPRG_06603; -.
DR   OMA; CKETSHR; -.
DR   OrthoDB; 71056at2759; -.
DR   Proteomes; UP000030745; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030745}.
FT   DOMAIN          354..579
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          210..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          316..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   827 AA;  90943 MW;  DD588D1FC76DDE96 CRC64;
     MAAEVKRGIV GVRGTWMWRD RDVVVARNGE LLVYRKGTTT LKLKIHLWDP AVQITFHADD
     ALLRIKTRCD DVLFDCKETS HRDTWLATIY TVQAMAPPVP SSSSPGVVAL DDSDDSDDGD
     FEIYADETET LAAFQKVRRS ITCDLGVDAS DGNDTATVNE AEQAKHWNAL AAYIEHVDGA
     GRSVLLHWDV LLALPVGLSM ANLLTALGER NRPASSPTTA PQGRRKTSAS QKTLVTAFVR
     DLLFHHTYGH RLGKDAQMAA NIHLIDKYFP HCRLRRFSNL DDKDVPVVVA ATQLTNSPAP
     PPSVRLLPQR GNRHILVQSD KNPSPPSTPP PPRSLSPLAT LQTLRSLLER HSMTPEAFAE
     QCTLFHRSQL GNVPLPTFLG PATCEQKAIS DHFNKLTAYL VWSVVAEESP LERAQAIETI
     TAIAVAANGH ELNNFHLVMA SIGCLGDTPL MPSRLPATWK RVRAKCKAQL FELRSLCDHN
     GGFETLRKKQ LLMSGTAATL PFLGVVGATL ERLRTTPLFT AGRIDVEKLT RQYDALRVVE
     NALERSYVFP AHDGVQAFLQ GLPPPMDGLQ SRSLALQSIE ASYMSSSAFR VASFGDIPPR
     RSSTSSEANR VVPFKFACAL QHTVPVASDR LALYMELLLV SDKTPVLKLV QSLLRDVHES
     LFLTSTQATC DLLVSRWDAL LTAMVTYCLP EIIDVVGPDG ALEPLLYESV VRAVFPAFAR
     SVYCKVVAEQ APITKTTRDQ SAQVHPLDAL LAPPSPIHAL QLIANVLATF PTTIAEHEFQ
     KLLHTSRVPS PRALRVFMAS SLDPTRLRDA LRQALAVYTR CIVDLAE
//