ID   A0A067CE61_SAPPC        Unreviewed;       996 AA.
AC   A0A067CE61;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=NFACT RNA-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=SPRG_07059 {ECO:0000313|EMBL:KDO27470.1};
OS   Saprolegnia parasitica (strain CBS 223.65).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Saprolegnia.
OX   NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO27470.1, ECO:0000313|Proteomes:UP000030745};
RN   [1] {ECO:0000313|EMBL:KDO27470.1, ECO:0000313|Proteomes:UP000030745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO27470.1,
RC   ECO:0000313|Proteomes:UP000030745};
RX   PubMed=23785293;
RA   Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA   van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA   Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA   Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA   Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA   Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA   Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA   Russ C., Tyler B.M., van West P.;
RT   "Distinctive expansion of potential virulence genes in the genome of the
RT   oomycete fish pathogen Saprolegnia parasitica.";
RL   PLoS Genet. 9:E1003272-E1003272(2013).
CC   -!- SIMILARITY: Belongs to the NEMF family.
CC       {ECO:0000256|ARBA:ARBA00008318}.
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DR   EMBL; KK583217; KDO27470.1; -; Genomic_DNA.
DR   RefSeq; XP_012201908.1; XM_012346518.1.
DR   AlphaFoldDB; A0A067CE61; -.
DR   STRING; 695850.A0A067CE61; -.
DR   EnsemblProtists; KDO27470; KDO27470; SPRG_07059.
DR   GeneID; 24129367; -.
DR   KEGG; spar:SPRG_07059; -.
DR   VEuPathDB; FungiDB:SPRG_07059; -.
DR   OMA; MFLEFFA; -.
DR   OrthoDB; 129892at2759; -.
DR   Proteomes; UP000030745; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProt.
DR   Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR   InterPro; IPR021846; NFACT-C.
DR   InterPro; IPR008532; NFACT_RNA-bd.
DR   PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR   PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR   Pfam; PF11923; NFACT-C; 1.
DR   Pfam; PF05670; NFACT-R_1; 1.
DR   Pfam; PF05833; NFACT_N; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030745}.
FT   DOMAIN          492..605
FT                   /note="NFACT RNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF05670"
FT   DOMAIN          855..972
FT                   /note="NFACT protein C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF11923"
FT   REGION          655..780
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          796..830
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          973..996
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        707..740
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        802..816
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   996 AA;  109210 MW;  6233C26D22D812AC CRC64;
     MKTRMAIDDI SAMVGSITKN VVNMRVTNIY DSEVNKTYIL KLATPGLPKV FLLLQSGVRF
     HTTAYARETA SALPLQFTMK LRKHLRGKRL ASVTQCASDR VIDFAFGDGD QRHHLILELY
     AAGNIILTDH NYSILSLLRS HTYDEQVKVA VKQVYPMENA MVVGNSAAAV FRSGSDLITF
     IQTKSKKQYT LKQILMSKES GLGGFGPTIV EHCLVKAHLA PSLKVKTAAT NVVVPLTPDE
     ADALVASLAQ APTLLDELAQ NQVTLHGEGS DASDVSDHGF IILSPTTGAF DEFTPYLYAQ
     HEGRSVQRFR TFDMATKVDK LKKHQQDQME AFRKTQEESV VQAQLIEQNQ GDIENVLLVL
     RSALANGMDW KDLEDLIKQE QKNGNPVASL IHKLDLAQNR VSVLLCDTEA DDADMESAVA
     YCVPIDLSLS ALANARELYS KKKKAVVKAQ KATEATDKAI EQAIKKHEKK QQAQKLQRKT
     LYQRRKTMWF EKFHWFITRE KYMVLAGKDA QQNETLVKKY LRKGDLYVHA DLHGAATCII
     RNRSADANDP IPISTIEQAG CMSVCRSNAW ANQVVAGAYW VRADQVSKTA PTGEYLTTGS
     FMIRGKKNFI PASRLEMGLA IVFRIDESSV AHHLELEALE NDDVTPRAVA VVDDEKPAAA
     ETSTVVAPKP TAKTKPAKPQ PEVKAAPVVA PDDEPSSDAE SPDGNGADDD APGKKRLSAK
     ERRDLKKART KKDEDDAAEV KASPPPAPTE KKPKGAAPAP PVRGKKGKLK KMKKYADQDE
     DERLLRLAAL GHVKVAELTE AGENDKEDET PANDETEDAT PSEAGTSVVD DEKEAIYALH
     RERKAQLQEQ EEEEAQNAAF LDSFTGTPLP NDLLLFAMPV CAPYSTLALY TYKVKLTPGS
     QKKGKAVQFA VDHFLNLKPK ISSAIKTTPV DVDAATDEVT PDVDPIEAQK ELIKCVPEAD
     LVGCMVGPVK VSAPGLSTAK KGGNNKPKKA HKNKST
//