ID   A0A067CIL0_SAPPC        Unreviewed;       762 AA.
AC   A0A067CIL0;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=CSC1/OSCA1-like 7TM region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=SPRG_05059 {ECO:0000313|EMBL:KDO30348.1};
OS   Saprolegnia parasitica (strain CBS 223.65).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Saprolegnia.
OX   NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO30348.1, ECO:0000313|Proteomes:UP000030745};
RN   [1] {ECO:0000313|EMBL:KDO30348.1, ECO:0000313|Proteomes:UP000030745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO30348.1,
RC   ECO:0000313|Proteomes:UP000030745};
RX   PubMed=23785293;
RA   Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA   van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA   Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA   Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA   Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA   Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA   Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA   Russ C., Tyler B.M., van West P.;
RT   "Distinctive expansion of potential virulence genes in the genome of the
RT   oomycete fish pathogen Saprolegnia parasitica.";
RL   PLoS Genet. 9:E1003272-E1003272(2013).
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DR   EMBL; KK583202; KDO30348.1; -; Genomic_DNA.
DR   RefSeq; XP_012198958.1; XM_012343568.1.
DR   AlphaFoldDB; A0A067CIL0; -.
DR   EnsemblProtists; KDO30348; KDO30348; SPRG_05059.
DR   GeneID; 24127468; -.
DR   KEGG; spar:SPRG_05059; -.
DR   VEuPathDB; FungiDB:SPRG_05059; -.
DR   OMA; DDIDWEC; -.
DR   OrthoDB; 231434at2759; -.
DR   Proteomes; UP000030745; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR   InterPro; IPR045122; Csc1-like.
DR   InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR   InterPro; IPR032880; Csc1/OSCA1-like_N.
DR   PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR   PANTHER; PTHR13018:SF98; TO DEHYDRATION PROTEIN, PUTATIVE, EXPRESSED-RELATED; 1.
DR   Pfam; PF14703; PHM7_cyt; 1.
DR   Pfam; PF13967; RSN1_TM; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        26..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        118..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        159..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        408..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        469..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        510..529
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          29..179
FT                   /note="CSC1/OSCA1-like N-terminal transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF13967"
FT   DOMAIN          206..397
FT                   /note="CSC1/OSCA1-like cytosolic"
FT                   /evidence="ECO:0000259|Pfam:PF14703"
SQ   SEQUENCE   762 AA;  86422 MW;  873DCD526BFB8F48 CRC64;
     MHNASQRDIW HVDYGRKRLE QAAQGWWSIM VVFGVNSVGF CVAWCLFLAS RSSRSSLYWM
     GTTDTTATTY RAHFGAHATP FERFKAFYHK FRDIQSLHIE VGDEAAFYLT FQVYALRLVL
     AMSGFAFFVL VPVYVFAAST PWSAFSTLTI RSLPDKSPLL WVPVITTYIF SLFYGIFLHK
     LGRLCNNRDP AKTNLLCMIP SSLSARSILV SSGVPKRMAQ DRILYLLDQI FPGYMSHVTV
     VYDLGPYRRL HTQRIAAEDR IERLQLLLRM QLTNSVPWML RLLPGSLRFP EPTCLQAPLE
     DQVASLQASI AESKRLEART LASIIAKNAG TGRIFLIFND PKWKARFVKK TKYKSITHIL
     ARAPKKYHNT LKRKIDELQL TQWTLDAAPE PDDIDWECVS YQSTKRTLLT ATIYTFLTVF
     IILFTSPLAV TSAISSGAYS TTAKWVNDIV FEVQDCVAGL SPVVAKMTFS YIPTMILVML
     NAVLLNVVYH AGRMQPMSTD SAKEKSILHY SAVCTFTGLT LCFPGFHIVC IRFDFQYAVC
     AKLYVCLDQR ALPVLSRQGP SPRPLRNALP QQLGCLLCQL RHSAGVCGHG RRHAAHFRGR
     RVCVALVPRR DTKRARVRGR RVEVLYGHAV GSANQCARRH CRLQHGRARD LAVWRVLLFH
     AAPRRQVFSF VRPTAHQGQW CDRQDEHPRK HVPAHDLPVC DGRLLPRPRH TLPKHVHRRA
     PHAHVHSDPM ALHWRQGAAS ACRRQGVCSR PDDAALADVW VG
//