ID A0A067CJ00_SAPPC Unreviewed; 4149 AA.
AC A0A067CJ00;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KDO29155.1};
GN ORFNames=SPRG_05399 {ECO:0000313|EMBL:KDO29155.1};
OS Saprolegnia parasitica (strain CBS 223.65).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO29155.1, ECO:0000313|Proteomes:UP000030745};
RN [1] {ECO:0000313|EMBL:KDO29155.1, ECO:0000313|Proteomes:UP000030745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO29155.1,
RC ECO:0000313|Proteomes:UP000030745};
RX PubMed=23785293;
RA Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA Russ C., Tyler B.M., van West P.;
RT "Distinctive expansion of potential virulence genes in the genome of the
RT oomycete fish pathogen Saprolegnia parasitica.";
RL PLoS Genet. 9:E1003272-E1003272(2013).
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DR EMBL; KK583207; KDO29155.1; -; Genomic_DNA.
DR RefSeq; XP_012200034.1; XM_012344644.1.
DR STRING; 695850.A0A067CJ00; -.
DR EnsemblProtists; KDO29155; KDO29155; SPRG_05399.
DR GeneID; 24127795; -.
DR KEGG; spar:SPRG_05399; -.
DR VEuPathDB; FungiDB:SPRG_05399; -.
DR OMA; HAIVCER; -.
DR OrthoDB; 312149at2759; -.
DR Proteomes; UP000030745; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46961:SF5; DYNEIN HEAVY CHAIN 6; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030745}.
FT DOMAIN 894..1294
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1425..1767
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1936..2059
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2267..2356
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2411..2671
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2686..3031
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3061..3286
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3532..3645
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3677..3818
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3825..4145
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2931..2965
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4149 AA; 464632 MW; FABD0F0F62A269D5 CRC64;
MLHAQTTVKP PKKERPSPAS SIASVLGQLD AYERSVCNKK SDLTLPIVGA PAPSLSPSKS
RQKLIKQIQS NASLDRGPPP PGPPPPPENV SLVEYLEAVV PVEKLVDHAN ALTRPQLPIA
CYADLDDAGG RAFLTTGPKK AVALAMDART GAIGHWSACT VIAYDANASV FVVAWLAGAR
IGAPLVPRVL LCFEAEPRAP FVARLSAALA LRSEAEARLR YELYVESMPP DVEAQLDADR
VNSILSFALS SSRLSTNART SKLLEEVNEG YMRTMNAILL ATNLRDVARE FPMLRLPTPN
VVPDVPAFGT VQVPIYDFNQ RRHNATLDSF LSAPPAIHAL LDVRHACNNM GSHLLLKTDQ
TSDAAVAPRS VVLPDFLSAQ TLANQNAMRF LRDNWTRSAA KCIINHMGPH YNLLESHRSV
YESSPLRRVL RRVNLVAEDS LRDVVTDTFQ AYAAFVQSMC AKTVVIADTH DVRVDTHGKP
SYVALFKVDV VISGAPKVLN EAAVHERAAA IAAWDSDEPC PLEPIAPELG HDFEYATPPH
AFADAVVSQL GLALDRVKTL ELIERIVMDR LFWPNQDTIA CVSMDEPWVV TLVASMQVAL
TEALSPMHAY LALLAKHIPL LNLNVLEYLG SLLKAPEAKD DPNEIDVTPP MEINELRRVI
LKHREAERLI LEALPSTPVN LGLVAVDVGH VRLFLAKKHA EIYTKLLETQ VAFCYRLATK
LTSSFDEINA NLAVTPKDVE GLTALQEYIA SVPATLQPLQ EDIRVMLLNN DLVDDFGFLV
SDEHLRLKWN VLGWPGRIHT QSARFKWALD ERKAKFAKQM EAEQERFEKT LAALVEEVDA
FARYDNLAHV EDIAHHAMAV QKKLDQASSD AAIFNSREVL FGKDMTSYDV LALAKKTFEP
YNQLWGTAYN WLQSRKQWTQ GSFSDVNAEE IERAVETYGG TIAKAAKFFN ASGNEACARI
AETIKEQVGV FKPYVPLILG LRNPGMRPRH WAELSKVLGF TLELDESFTL NSIFRLNLLD
QIDEIVKVAE AAGREYQIEA ALNAMKTQWE AIDLQILSYR ETGTYIIKGV DEIQIVLDEH
ITMTQAMMFS SFKGPFEERI TEWNGTLQLI SEILEEWLAV QRSWLYLQPI FESPDINKQL
PLEGKRFASV DKNWRQTLAS ARAKPRCVDF CNSGKLLEKF HESNVFLDMV QKGLSDYLEV
KRSSFARFYF LSNDELLSIL SESKDVKLVQ PHLKKCFEGI VKVEFQDDLT ITAMISAEGE
SVRMHEPIDP KNKNVELWML EVENMMRTSI RDTMHCSIVD YIKVDRSKWV QKWPGMCVLN
ASQMHWTREM EEAMDKFGAD GVKLMLNRQL GQLADMVTMV RGHLDKMTRI TLGALTVIDV
HARDVTKKLV AQNVQSKADF LWSSQLKYYW DDDLFAQMVT SKRPYGYEYL GNSFRLVITP
LTDKCYLTLM GALQMILGGA PAGPAGTGKT ETTKDLAKAL AKQCVVFNCS DGLDFIAMGK
FSRYHVATHL IVGTNMGMKG LASCGAWACF DEFNRIDIEV LSVVGQQVMT LQLGIRRGEK
RIVFEDSDIK LSDQFGVFIT MNPGYAGRSE LPDSLAALFR PVAMMVPDYA LIGEIMFFAY
GFADAHALGA KMVTTFKLCS EQLSSQCHYD YGMRAVKTVI TAAGNLKRSD PDMDEDVLLL
RALQDVNLPK FLAHDIPLFN GIISDLFLGK QRPVIDLGAL ISVIKLQTQK MQLQPVPYFL
TKCIQLYETI VVRHGLMVVG ATGGGKSCNI EVLAQALSEL KSRNEPGFAY EKVIKYQLNP
KSITMGQLYG EFDANTHEWQ DGILSTLYRT AASCTKSDRK WIIFDGPVDA IWIENMNTVL
DDNKKLCLNS GEMLQMSYQM TMMFEVEDLS VASPATVSRT GMVYMEPSTL GLNPLVMSWL
EKLPKTLSVH APSFLRLFDI YLHAAVIFMR SYLIELVPTI DNNLAQSLLS LLNCFLGPYL
ATEPIAPDAA FRNDIEPMFL FSLIWSIGAT TNDLGRLRFD AYVRLQMLAN NAATLFPAKG
LVYDYSYSMK EHKWVFWMDT IPVYRVPSGI SFAEIVVPTS DSVRNTYLLE QLVKTGKHVL
MTVNIARFLS SLPSEYMPVA MTFSAQTSAN QTQDLLDSKM EKRRKGVFGP PAGKTFVVYV
DDLNMPKREK YFAQPPLELL RQWFDQGGWY DRKLLQFRAI IDMQFVASMG PPGGGRNPIT
MRLLRHFNVV CYAELGDDNK AIIFATILNN FLSAFPAEVQ RLETPIVTAS IEVYNTICKE
LLPTPAKSHY TFNLRDLAKV FQGCLMCDPR KVTDAHGFLR LWVHENKRVF EDRMVCADDH
AWFAALLSTT CATAFDTDLA SIVTTPYLLY GDYLVPGADP KIYEEVVDVA KLLPIVEEYL
ADHNAESKTP MPLVLFIDAV EHVSRIARIL RQPLGNALLL GVGGSGRQSL TKLATFMAGY
KCFQVEIVKG YGMTEWRDDV KRCLLLAGLK DSPVVFLFSD VQVVNETMLE DLNGVLNSGS
VPNLYGPEDM DQIVNACKAD CQKKSIPPTK TNIFAQYIVR VRKNIHLVIC MSPIGNAFRD
RLRMFPSLVN CCTIDWFSEW PAEALNSVAT AILSDGNLQL GSPDQMQHLV EVIKCIHQSV
EHKSKEYYSI LRRYFYVTPT SYLELLATFK AVLVSKREDV NTMKSRLQNG VDKLSETKVL
VATMQDELVA LQPVLAATQI EVEQMMVQIT KDRAEADVTK AVVQKEEESA STKARATKEI
ADSAQKDLDE ALPALDAAVA CLNKLKKADI DEVKSLKTPP GGVKLTMEVV CLLFGHKPTM
KADPDKPGKK IADFWDVAQK VVLANANKFL ESLMGFDKDN IPDAVIAKVQ PYIDDPNFTP
DAIEKSSKAC TAICMWARAM YTYYFVAKSV EPKKQALAQA QTELDATMEI LRGAQAGLKQ
VTDRLAELEA SYNAAIAKKE ELAAKVIQCQ VQLSNADKLI GGLGGEETRW KATVAQLEKD
YVNLTGDVLV SAGTISYLGA FTAEFRDDLV SSWHGALVTY HVPHSAGCGI VGTLQDPVKL
RTWQIAGLPT DTVSTQNGII MSRARRWPLL IDPQGQANRF VKNLGKEKAL CENGMDVVKQ
SDKNFLRALE NGIRFGKWVV LENVTEELDA ALEPVLLQQK FKQGGQDVIR LGENVIPYNE
SFRFYMTSKL ANPHYPPEVC VKVSLLNFTI TMKGLEEQLL NVVVQKEMPE LAEKKNELVL
SNAASKRQLY EIENQILYLL SHSQGNILDD TNLIETLASS KQTSAVVVEK MKEAEETEKE
IDARSDGYRP VAYRAALLFF CIADLARVDP MYQYSLPWFT SIFVRSILAA KPSPQLATRL
QNLNDYFTYS IYKNVCRSLF EKHKLLFSFL LTIKILMGNN EIDGLEWRFL LSGMAPNTLT
VENPAPTWLE GYAWTELCRL ATLPAFEGFT EAFAAHKAVY RGLFDSPEPH VVPLPGGWQT
KLDAFQRLCV LRSLRPDKMM EGIQNLVVEK LGQPFIEPPP FDLLETFEDS TPVSPLIFVL
SQGSDPAKDL LTFAIATKMD AKLKSIALGQ GQGTLAARLI ENAVQKGEWV LLQNCHLALS
WMPDLERICE ELDPAKLHVD FRLWLTSMPT PVFPTSVLQN GVKMTKEAPK GLRANLKNTY
YKLNDDALSV TAKPDVFRKL LFGLCFYHAI VCERKRFGAL GWNIPYSFNE TDLDISVAQL
EMFLDTYDKV PFEVLQVMTS MINYGGRITD DKDMRTSDVI LMTYFCPAIL ESGYKFSTSG
VYYSLAANPK TPYASYVEYI NSLPINPEPE VFGMHENANI TCAQAETYDV FDIILSLQPR
VSAGAGLSRE DTIASAAATI EASLPPHFDL EFVQVKYAVS YTESMNTVLA QEVERFNKLL
TVMKETLQQV QRGLRGLIVL SAELEAMGNS LYDQKVPLLW EAKAYPSLKP LTSWVADLLE
RLHFISHWID HGIPIVFWIS GFFFPQGFMT GIIQNHARRQ KLPIDTLSFQ YLMMREELAD
VTTRPDEGCY IYGLFLEGAR WNKDIASLDD PFPKELFAKM PLMHLHPQQK REAPANGIYR
CPVYKILTRT GTLSTTGHST NFVMWIEIPS NRPTIWRNSL VSETNAQVLF CDQEYWIKAG
VACFCALRY
//
