ID A0A067CKR4_SAPPC Unreviewed; 715 AA.
AC A0A067CKR4;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=TKL protein kinase {ECO:0000313|EMBL:KDO29775.1};
GN ORFNames=SPRG_04891 {ECO:0000313|EMBL:KDO29775.1};
OS Saprolegnia parasitica (strain CBS 223.65).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO29775.1, ECO:0000313|Proteomes:UP000030745};
RN [1] {ECO:0000313|EMBL:KDO29775.1, ECO:0000313|Proteomes:UP000030745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO29775.1,
RC ECO:0000313|Proteomes:UP000030745};
RX PubMed=23785293;
RA Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA Russ C., Tyler B.M., van West P.;
RT "Distinctive expansion of potential virulence genes in the genome of the
RT oomycete fish pathogen Saprolegnia parasitica.";
RL PLoS Genet. 9:E1003272-E1003272(2013).
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DR EMBL; KK583204; KDO29775.1; -; Genomic_DNA.
DR RefSeq; XP_012199421.1; XM_012344031.1.
DR AlphaFoldDB; A0A067CKR4; -.
DR STRING; 695850.A0A067CKR4; -.
DR EnsemblProtists; KDO29775; KDO29775; SPRG_04891.
DR GeneID; 24127308; -.
DR KEGG; spar:SPRG_04891; -.
DR VEuPathDB; FungiDB:SPRG_04891; -.
DR OrthoDB; 54134at2759; -.
DR Proteomes; UP000030745; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00030; C2; 1.
DR CDD; cd13999; STKc_MAP3K-like; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR44329:SF214; ANKYRIN REPEAT-CONTAINING PROTEIN KINASE A-RELATED; 1.
DR PANTHER; PTHR44329; SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00220; S_TKc; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:KDO29775.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000313|EMBL:KDO29775.1}.
FT DOMAIN 1..106
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 190..452
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 449..715
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 217
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 715 AA; 78576 MW; 1BE1F48DDD1BE62E CRC64;
MLVVVHVAEA KDLKSHKMFR SVNHAYVNLY YAGKKVTSDV AHNQKNAPRW GLKKRFANIN
PACDSAIRLD VFDQGQWGRS EMFIGYCEVA VPVRPKRVDF WVPIKVEDAT TGSVFVHIDC
TAEPSQILPR SQRDQDYAMP RQVAPYLLPM PPQGAPYQLP MRRMGSLSDS FLQLAAALPE
TVPRIEPTEL RTCRHLGSGA FGNVHSGSYK DLTVAIKTFH VKSGDEIEMF KKEVNVMAGL
DSTHTVQLLG ITHAANDQPQ IVMEFMDGGN LDKHIKSLAA APEHDVSKVL HLACGIGKGL
AYLHDQGIIH RDLKPANVLL SADKTVVKLG DFGISREEVK ESMTNGVGTT LWMSPEVMQG
GRYSVAADMY AFGVILTELE TLQSPYAGLN LRRYVLQDKI AKEGLRPTMS TKCPPWYARL
AQDCMQANPN KRPSAVDVVG ILEAHMASSP SLQLIPEELL RDIVPFTSSK RCVLGRATLA
FRPVVLKTFP SMKSDVFKDM VDVMRAVASP HTVPLLGTTL LSSTAIMGLA SPCVLVMAYM
PGGNLHTWLT QRSNVDFLDT ARAIAEAVAY LHAKKVVHGN LTPSNVLFDA AGQPKLTDFG
YGRDEDMMTT NGGNATHWMA PEILHDDMPS TASDVYSLGV LLTQLETGRE PYWDLKSNLQ
RRVAQIVTGA LRPSLSASCP PWYRKLAQAC MAGDAMHRPS AAEIVSELVK HTAKP
//
