ID A0A067CM98_SAPPC Unreviewed; 642 AA.
AC A0A067CM98;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Methionine synthase reductase {ECO:0000256|ARBA:ARBA00040659};
DE EC=1.16.1.8 {ECO:0000256|ARBA:ARBA00039088};
GN ORFNames=SPRG_03729 {ECO:0000313|EMBL:KDO31809.1};
OS Saprolegnia parasitica (strain CBS 223.65).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO31809.1, ECO:0000313|Proteomes:UP000030745};
RN [1] {ECO:0000313|EMBL:KDO31809.1, ECO:0000313|Proteomes:UP000030745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO31809.1,
RC ECO:0000313|Proteomes:UP000030745};
RX PubMed=23785293;
RA Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA Russ C., Tyler B.M., van West P.;
RT "Distinctive expansion of potential virulence genes in the genome of the
RT oomycete fish pathogen Saprolegnia parasitica.";
RL PLoS Genet. 9:E1003272-E1003272(2013).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
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DR EMBL; KK583197; KDO31809.1; -; Genomic_DNA.
DR RefSeq; XP_012197689.1; XM_012342299.1.
DR AlphaFoldDB; A0A067CM98; -.
DR STRING; 695850.A0A067CM98; -.
DR EnsemblProtists; KDO31809; KDO31809; SPRG_03729.
DR GeneID; 24126213; -.
DR KEGG; spar:SPRG_03729; -.
DR VEuPathDB; FungiDB:SPRG_03729; -.
DR OMA; LFFGHQR; -.
DR OrthoDB; 9164at2759; -.
DR Proteomes; UP000030745; Unassembled WGS sequence.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR19384:SF84; METHIONINE SYNTHASE REDUCTASE; 1.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00369; FLAVODOXIN.
DR PRINTS; PR00371; FPNCR.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643};
KW Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000030745}.
FT DOMAIN 8..153
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 254..489
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 642 AA; 69381 MW; 7170E02C59B74DD3 CRC64;
MVDATTPLYV FYGSQTGCAE SIAERLQSDA IERNVPCHEV RPLDAFEKSG VLQDVAAKVV
IVCSTTGNGD PPGNAEKFWR YIKKRAHPAT LLSSISFTVL GLGDTNYDKF CHMGKSIFRR
MKDLGAVSFY DLGCADEAMG LEDSVEPWID GFWPALLGAS TAVTVTPIAD DTTVVAAITD
SMAAVSMTSA PALLPSQPFL ASFESLLGDA VVEPDAAKLP RLHEPSFSVS LLAPSDAIAK
TVAQVATDTL YSASSPFLAA IASARYLTTP ASIDRTVFAL DFDLANSGMT YAPGDVLGVN
CPNDDGLVAF FLQRLQLSAF ADHQVQLAPI ASSKKKVSGM PFPAHATLRD VVRDHLDLAA
LPKKATLRAL APHCADAKER TRRRGCFKTF IDAQYLSVLE VLSLFPSCHP PLPLLLSLMP
RLSPRYYSIA SSPLASPTRA TIALTRVAYT QHGIPRHGLC SNWLHDVAFS TATTRIPIFL
KPATDFVLPD DASRPLVLIG PGTGVAPFMG FVQHRSLQAA STPIHLFFGC RSKTQDFLFG
DELQRYADSG VLTTLALAFS RDQAEKHYVQ HELALHGATV YDALAKANGM VYVCGDGMHM
ARDVHEALVS VFESHGTLSR DDAEAQLKQL ALDARYVRDI WC
//
