ID A0A067CTK3_SAPPC Unreviewed; 1005 AA.
AC A0A067CTK3;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Tr-type G domain-containing protein {ECO:0000259|PROSITE:PS51722};
GN ORFNames=SPRG_03049 {ECO:0000313|EMBL:KDO32575.1};
OS Saprolegnia parasitica (strain CBS 223.65).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO32575.1, ECO:0000313|Proteomes:UP000030745};
RN [1] {ECO:0000313|EMBL:KDO32575.1, ECO:0000313|Proteomes:UP000030745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO32575.1,
RC ECO:0000313|Proteomes:UP000030745};
RX PubMed=23785293;
RA Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA Russ C., Tyler B.M., van West P.;
RT "Distinctive expansion of potential virulence genes in the genome of the
RT oomycete fish pathogen Saprolegnia parasitica.";
RL PLoS Genet. 9:E1003272-E1003272(2013).
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DR EMBL; KK583195; KDO32575.1; -; Genomic_DNA.
DR RefSeq; XP_012197020.1; XM_012341630.1.
DR AlphaFoldDB; A0A067CTK3; -.
DR STRING; 695850.A0A067CTK3; -.
DR EnsemblProtists; KDO32575; KDO32575; SPRG_03049.
DR GeneID; 24125582; -.
DR KEGG; spar:SPRG_03049; -.
DR VEuPathDB; FungiDB:SPRG_03049; -.
DR OMA; YIFRPIR; -.
DR OrthoDB; 166721at2759; -.
DR Proteomes; UP000030745; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd04098; eEF2_C_snRNP; 1.
DR CDD; cd04090; EF2_II_snRNP; 1.
DR CDD; cd01683; EF2_IV_snRNP; 1.
DR CDD; cd16264; snRNP_III; 1.
DR CDD; cd04167; Snu114p; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 3.90.1430.10; Yeast translation eEF2 (G' domain); 1.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR031950; EFTUD2_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR044121; Snu114_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR InterPro; IPR035655; U5-116kDa_C.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42908:SF6; 116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT; 1.
DR PANTHER; PTHR42908; TRANSLATION ELONGATION FACTOR-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF16004; EFTUD2; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000030745}.
FT DOMAIN 140..378
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..48
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1005 AA; 111452 MW; CD6781CAE91EF1B7 CRC64;
MSESLYDEFG NYIGPELDDS NSESEEEREE SEQEDGASDD EAASGQEADD DDNMGREPSS
ALSTYREEDH RIVLHEDKQY YPDAEEVFGD AEVLVMEEDA QAIETPLVAP VKVKEFSSAE
QPPKTTYSND FLASLMDHPS MVRNVAVVGD LHAGKTVLLD LLVEATHEVK WKDQQTDATK
KAMAVELERR YTDTRMDEQA RKVSIKSTPV SLVLPSSNGK SFIMNIIDCP GHVNFSDETT
AAMQVADGAV LVVDAIEGVM MNTERIVKAA LLSKLPILLV VNKVDRLIIE LKLPPADAYF
KLLHTIEEVN KIIETHTPLG QPAKRVSPEL GNVCFASAQH GWHFSLESFS RLYSEIHRGV
NPTELAKRLW GDMYYAPATR TFKKKVPYEN APRSFVSFIL EPIYKIYAQV LGEDTATLSK
TLRDLGLRVR REDLHLNPRP LLKLVLSQFL GRSASSFVDM VSRHVPSPLE TAAIKVKSLY
TGDMDSKVAA AMLACDPTGP LMLNIVKLYS STDGTTFSAF GRVYSGAVTT NQRVKVLGDS
YSIDDDEDMC VRSVEAVGIS QGRYSVRVNR IVAGNWVLLE GVDSSIINSA TITDASEDVL
ESERVGIFTP LAQRFGTSAV VKLAVEPLNP SELPKMLEGL RKISKSYPLV TTKVEESGEH
VILCTGELAA DCILHDLRKM YSEIEIKVAD PVTSFCETVI ETSSVQCFAE TPNQKNKLTM
IAEPLDVGLA KDIEAGVVSL DWPKKDVAEF FQNQYQWDVL AARSVWAFGP DAKGPNVLID
DTLSSEVDKK ALNSVKNSIV QGFQWGCREG PLCDEPIRSS KFKILHASLA NEPIHRAGGQ
LIPTARRVVY SSFLTATPRL LEPMYALEIQ CPADTVATLY QVLTRRRGHI TQDTPKAGSP
MYTVRGFLPV IESFGFETDL RVFTQGHAFC TQTFDHWALV PGDPLDANII LRPLEPSPVD
ALAREFMVKT RRRKGLSEEV NVSKFFDDPM LQELAKHDLD ADHLM
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